Universität zu Köln

Anthon, Carl Thomas ORCID: 0000-0001-7740-700X, Pene, Frederic, Perner, Anders, Azoulay, Elie, Puxty, Kathryn, Van de Louw, Andry, Barratt-Due, Andreas, Chawla, Sanjay, Castro, Pedro, Povoa, Pedro, Coelho, Luis, Metaxa, Victoria, Munshi, Laveena, Kochanek, Matthias, Liebregts, Tobias, Kander, Thomas ORCID: 0000-0002-5404-2981, Hastbacka, Johanna, Moller, Morten Hylander and Russell, Lene ORCID: 0000-0001-7352-8728 (2022). Platelet transfusions and thrombocytopenia in intensive care units: Protocol for an international inception cohort study (PLOT-ICU). Acta Anaesthesiol. Scand., 66 (9). S. 1146 - 1156. HOBOKEN: WILEY. ISSN 1399-6576

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Abstract

Introduction Thrombocytopenia is frequent in intensive care unit (ICU) patients and has been associated with worse outcome. Platelet transfusions are often used in the management of ICU patients with severe thrombocytopenia. However, the reported frequencies of thrombocytopenia and platelet transfusion practices in the ICU vary considerably. Therefore, we aim to provide contemporary epidemiological data on thrombocytopenia and platelet transfusion practices in the ICU. Methods We will conduct an international inception cohort, including at least 1000 acutely admitted adult ICU patients. Routinely available data will be collected at baseline (ICU admission), and daily during ICU stay up to a maximum of 90 days. The primary outcome will be the number of patients with thrombocytopenia (a recorded platelet count < 150 x 10(9)/L) at baseline and/or during ICU stay. Secondary outcomes include mortality, days alive and out of hospital, days alive without life-support, the number of patients with at least one bleeding episode, at least one thromboembolic event and at least one platelet transfusion in the ICU, the number of platelet transfusions and the indications for transfusion. The primary and secondary outcomes will be presented descriptively. In addition, we will assess risk factors for developing thrombocytopenia during ICU stay and the association between thrombocytopenia at baseline and 90-day mortality using logistic regression analyses. Conclusion The outlined international PLOT-ICU cohort study will provide contemporary epidemiological data on the burden and clinical significance of thrombocytopenia in adult ICU patients and describe the current platelet transfusion practice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Anthon, Carl Thomas UNSPECIFIED orcid.org/0000-0001-7740-700X UNSPECIFIED Pene, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Perner, Anders UNSPECIFIED UNSPECIFIED UNSPECIFIED Azoulay, Elie UNSPECIFIED UNSPECIFIED UNSPECIFIED Puxty, Kathryn UNSPECIFIED UNSPECIFIED UNSPECIFIED Van de Louw, Andry UNSPECIFIED UNSPECIFIED UNSPECIFIED Barratt-Due, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Chawla, Sanjay UNSPECIFIED UNSPECIFIED UNSPECIFIED Castro, Pedro UNSPECIFIED UNSPECIFIED UNSPECIFIED Povoa, Pedro UNSPECIFIED UNSPECIFIED UNSPECIFIED Coelho, Luis UNSPECIFIED UNSPECIFIED UNSPECIFIED Metaxa, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Munshi, Laveena UNSPECIFIED UNSPECIFIED UNSPECIFIED Kochanek, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Liebregts, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Kander, Thomas UNSPECIFIED orcid.org/0000-0002-5404-2981 UNSPECIFIED Hastbacka, Johanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Moller, Morten Hylander UNSPECIFIED UNSPECIFIED UNSPECIFIED Russell, Lene UNSPECIFIED orcid.org/0000-0001-7352-8728 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-697602
DOI:	10.1111/aas.14124
Journal or Publication Title:	Acta Anaesthesiol. Scand.
Volume:	66
Number:	9
Page Range:	S. 1146 - 1156
Date:	2022
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1399-6576
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CRITICALLY-ILL; RISK-FACTORS; OPEN-LABEL; EPIDEMIOLOGY; PREVALENCE Multiple languages Anesthesiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69760