Universität zu Köln

Bannister, Wendy P., Mast, T. Christopher, de Wit, Stephane, Gerstoft, Jan, Wiese, Lothar, Milinkovic, Ana, Hadziosmanovic, Vesna, Clarke, Amanda, Rasmussen, Line D., Lacombe, Karine ORCID: 0000-0001-8772-9029, Schommers, Philipp, Staub, Therese, Zagalo, Alexandra, Portu, Joseba J., Tau, Luba, Calmy, Alexandra ORCID: 0000-0002-1137-6826, Cavassini, Matthias, Gisinger, Martin, Borodulina, Elena, Mocroft, Amanda, Reekie, Joanne and Peters, Lars (2022). Changes in body mass index and clinical outcomes after initiation of contemporary antiretroviral regimens. Aids, 36 (15). S. 2107 - 2120. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1473-5571

Full text not available from this repository.

Abstract

Background:Weight gain is becoming increasingly prevalent amongst people with HIV (PWH) receiving contemporary antiretroviral treatment. We investigated BMI changes and clinical impact in a large prospective observational study.Methods:PWH aged >= 18years were included who started a new antiretroviral (baseline) during 2010-2019 with baseline and >= 1 follow-up BMI assessment available. Rates of clinical outcomes (cardiovascular disease [CVD], malignancies, diabetes mellitus [DM] and all-cause mortality) were analysed using Poisson regression to assess effect of time-updated BMI changes (>1kg/m(2) decrease, 1kg/m(2) stable, >1kg/m(2) increase), lagged by 1-year to reduce reverse causality. Analyses were adjusted for baseline BMI plus key confounders including antiretroviral exposure.Results:6721 PWH were included; 72.3% were male, median age 48years (interquartile range [IQR] 40-55). At baseline, 8.4% were antiretroviral-naive, and 5.0% were underweight, 59.7% healthy weight, 27.5% overweight, and 7.8% were living with obesity. There was an 8.2% increase in proportion of overweight and 4.8% in obesity over the study period (median follow-up 4.4years [IQR 2.6-6.7]).100 CVDs, 149 malignancies, 144 DMs, and 257 deaths were observed with incidence rates 4.4, 6.8, 6.6, 10.6 per 1000 person-years of follow-up, respectively. Compared to stable BMI, >1kg/m(2) increase was associated with increased risk of DM (adjusted incidence rate ratio [IRR]: 1.96, 95% confidence interval [CI]: 1.36-2.80) and >1kg/m(2) decrease with increased risk of death (adjusted IRR: 2.33, 95% CI: 1.73-3.13). No significant associations were observed between BMI changes and CVD or malignancies.Conclusions:A BMI increase was associated with DM and a decrease associated with death.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bannister, Wendy P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mast, T. Christopher UNSPECIFIED UNSPECIFIED UNSPECIFIED de Wit, Stephane UNSPECIFIED UNSPECIFIED UNSPECIFIED Gerstoft, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiese, Lothar UNSPECIFIED UNSPECIFIED UNSPECIFIED Milinkovic, Ana UNSPECIFIED UNSPECIFIED UNSPECIFIED Hadziosmanovic, Vesna UNSPECIFIED UNSPECIFIED UNSPECIFIED Clarke, Amanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Rasmussen, Line D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lacombe, Karine UNSPECIFIED orcid.org/0000-0001-8772-9029 UNSPECIFIED Schommers, Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Staub, Therese UNSPECIFIED UNSPECIFIED UNSPECIFIED Zagalo, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Portu, Joseba J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tau, Luba UNSPECIFIED UNSPECIFIED UNSPECIFIED Calmy, Alexandra UNSPECIFIED orcid.org/0000-0002-1137-6826 UNSPECIFIED Cavassini, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Gisinger, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Borodulina, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Mocroft, Amanda UNSPECIFIED UNSPECIFIED UNSPECIFIED Reekie, Joanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Lars UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-697906
DOI:	10.1097/QAD.0000000000003332
Journal or Publication Title:	Aids
Volume:	36
Number:	15
Page Range:	S. 2107 - 2120
Date:	2022
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Place of Publication:	PHILADELPHIA
ISSN:	1473-5571
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALL-CAUSE MORTALITY; WEIGHT-GAIN; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; HIV; OBESITY; THERAPY; RISK; DOLUTEGRAVIR; PREVALENCE Multiple languages Immunology; Infectious Diseases; Virology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/69790