Costa, Giuliano, Pilgrim, Thomas ORCID: 0000-0001-8721-4068, Santos, Ignacio J. Amat, De Backer, Ole ORCID: 0000-0002-9674-0278, Kim, Won-Keun ORCID: 0000-0002-0799-7478, Ribeiro, Henrique Barbosa, Saia, Francesco ORCID: 0000-0001-9969-2649, Bunc, Matjaz, Tchetche, Didier, Garot, Philippe, Ribichini, Flavio Luciano, Mylotte, Darren, Burzotta, Francesco, Watanabe, Yusuke, De Marco, Federico, Tesorio, Tullio, Rheude, Tobias, Tocci, Marco, Franzone, Anna, Valvo, Roberto, Savontaus, Mikko, Wienemann, Hendrik, Porto, Italo ORCID: 0000-0002-9854-5046, Gandolfo, Caterina, Iadanza, Alessandro ORCID: 0000-0002-6435-1155, Santo Bortone, Alessandro, Mach, Markus ORCID: 0000-0002-3184-4914, Latib, Azeem, Biasco, Luigi, Taramasso, Maurizio, Zimarino, Marco, Tomii, Daijiro, Nuyens, Philippe, Sondergaard, Lars, Camara, Sergio F., Palmerini, Tullio, Orzalkiewicz, Mateusz ORCID: 0000-0001-8402-2650, Steblovnik, Klemen, Degrelle, Bastien, Gautier, Alexandre ORCID: 0000-0003-4378-299X, Del Sole, Paolo Alberto, Mainardi, Andrea, Pighi, Michele, Lunardi, Mattia, Kawashima, Hideyuki, Criscione, Enrico, Cesario, Vincenzo, Biancari, Fausto, Zanin, Federico, Joner, Michael, Esposito, Giovanni, Adam, Matti, Grube, Eberhard, Baldus, Stephan, De Marzo, Vincenzo, Piredda, Elisa, Cannata, Stefano, Iacovelli, Fortunato, Andreas, Martin, Frittitta, Valentina, Dipietro, Elena, Reddavid, Claudia, Strazzieri, Orazio, Motta, Silvia, Angellotti, Domenico, Sgroi, Carmelo, Kargoli, Faraj, Tamburino, Corrado and Barbanti, Marco ORCID: 0000-0002-4903-5437 (2022). Management of Myocardial Revascularization in Patients With Stable Coronary Artery Disease Undergoing Transcatheter Aortic Valve Implantation. Circ.-Cardiovasc. Interv., 15 (12). S. 950 - 963. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1941-7632

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Abstract

Background:The best management of stable coronary artery disease (CAD) in patients undergoing transcatheter aortic valve implantation (TAVI) is still unclear due to the marked inconsistency of the available evidence. Methods:The REVASC-TAVI registry (Management of Myocardial Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation With Coronary Artery Disease) collected data from 30 centers worldwide on patients undergoing TAVI who had significant, stable CAD at preprocedural work-up. For the purposes of this analysis, patients with either complete or incomplete myocardial revascularization were compared in a propensity score matched analysis, to take into account of baseline confounders. The primary and co-primary outcomes were all-cause death and the composite of all-cause death, stroke, myocardial infarction, and rehospitalization for heart failure, respectively, at 2 years. Results:Among 2407 patients enrolled, 675 pairs of patients achieving complete or incomplete myocardial revascularization were matched. The primary (21.6% versus 18.2%, hazard ratio, 0.88 [95% CI, 0.66-1.18]; P=0.38) and co-primary composite (29.0% versus 27.1%, hazard ratio, 0.97 [95% CI, 0.76-1.24]; P=0.83) outcome did not differ between patients achieving complete or incomplete myocardial revascularization, respectively. These results were consistent across different prespecified subgroups of patients (< or >75 years of age, Society of Thoracic Surgeons score > or <4%, angina at baseline, diabetes, left ventricular ejection fraction > or <40%, New York Heart Association class I/II or III/IV, renal failure, proximal CAD, multivessel CAD, and left main/proximal anterior descending artery CAD; all P values for interaction >0.10). Conclusions:The present analysis of the REVASC-TAVI registry showed that, among TAVI patients with significant stable CAD found during the TAVI work-up, completeness of myocardial revascularization achieved either staged or concomitantly with TAVI was similar to a strategy of incomplete revascularization in reducing the risk of all cause death, as well as the risk of death, stroke, myocardial infarction, and rehospitalization for heart failure at 2 years, regardless of the clinical and anatomical situations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Costa, GiulianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pilgrim, ThomasUNSPECIFIEDorcid.org/0000-0001-8721-4068UNSPECIFIED
Santos, Ignacio J. AmatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Backer, OleUNSPECIFIEDorcid.org/0000-0002-9674-0278UNSPECIFIED
Kim, Won-KeunUNSPECIFIEDorcid.org/0000-0002-0799-7478UNSPECIFIED
Ribeiro, Henrique BarbosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saia, FrancescoUNSPECIFIEDorcid.org/0000-0001-9969-2649UNSPECIFIED
Bunc, MatjazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tchetche, DidierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garot, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ribichini, Flavio LucianoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mylotte, DarrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burzotta, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Watanabe, YusukeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Marco, FedericoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tesorio, TullioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rheude, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tocci, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franzone, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valvo, RobertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Savontaus, MikkoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wienemann, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Porto, ItaloUNSPECIFIEDorcid.org/0000-0002-9854-5046UNSPECIFIED
Gandolfo, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iadanza, AlessandroUNSPECIFIEDorcid.org/0000-0002-6435-1155UNSPECIFIED
Santo Bortone, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mach, MarkusUNSPECIFIEDorcid.org/0000-0002-3184-4914UNSPECIFIED
Latib, AzeemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biasco, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taramasso, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimarino, MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomii, DaijiroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nuyens, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sondergaard, LarsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Camara, Sergio F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palmerini, TullioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Orzalkiewicz, MateuszUNSPECIFIEDorcid.org/0000-0001-8402-2650UNSPECIFIED
Steblovnik, KlemenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degrelle, BastienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gautier, AlexandreUNSPECIFIEDorcid.org/0000-0003-4378-299XUNSPECIFIED
Del Sole, Paolo AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mainardi, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pighi, MicheleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lunardi, MattiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kawashima, HideyukiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Criscione, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cesario, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biancari, FaustoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zanin, FedericoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Esposito, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adam, MattiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grube, EberhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldus, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Marzo, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piredda, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cannata, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacovelli, FortunatoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Andreas, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frittitta, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dipietro, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reddavid, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Strazzieri, OrazioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Motta, SilviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Angellotti, DomenicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sgroi, CarmeloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kargoli, FarajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tamburino, CorradoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barbanti, MarcoUNSPECIFIEDorcid.org/0000-0002-4903-5437UNSPECIFIED
URN: urn:nbn:de:hbz:38-697991
DOI: 10.1161/CIRCINTERVENTIONS.122.012417
Journal or Publication Title: Circ.-Cardiovasc. Interv.
Volume: 15
Number: 12
Page Range: S. 950 - 963
Date: 2022
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1941-7632
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
REPLACEMENTMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69799

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