Del Principe, Maria Ilaria, Seidel, Danila, Criscuolo, Marianna, Dargenio, Michelina ORCID: 0000-0003-0924-4629, Racil, Zdenek, Piedimonte, Monica, Marchesi, Francesco, Nadali, Gianpaolo ORCID: 0000-0002-0444-9644, Koehler, Philipp, Fracchiolla, Nicola ORCID: 0000-0002-8982-8079, Cattaneo, Chiara, Klimko, Nikolai, Spolzino, Angelica, Karapinar, Deniz Yilmaz, Demiraslan, Hayati, Duarte, Rafael F., Demeter, Judit, Stanzani, Marta, Melillo, Lorella Maria Antonia, Basilico, Claudia Maria, Cesaro, Simone ORCID: 0000-0002-8698-9547, Paterno, Giovangiacinto, Califano, Catello, Delia, Mario, Buzzatti, Elisa, Busca, Alessandro, Cornely, Oliver A. ORCID: 0000-0001-9599-3137, Pagano, Livio, Alakel, Nael, Arsenijevi'c, Valentina Arsi'c, Camus, Vincent, Falces-Romero, Iker, Itzhak, Levy, Kouba, Michal, Martino, Rodrigo, Sedlacek, Petr and Weinbergerova, Barbora (2023). Clinical features and prognostic factors of Magnusiomyces (Saprochaete) infections in haematology. A multicentre study of SEIFEM/Fungiscope. Mycoses, 66 (1). S. 35 - 47. HOBOKEN: WILEY. ISSN 1439-0507

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Abstract

Background Our multicentre study aims to identify baseline factors and provide guidance for therapeutic decisions regarding Magnusiomyces-associated infections, an emerging threat in patients with haematological malignancies. Methods HM patients with proven (Magnusiomyces capitatus) M. capitatus or (Magnusiomyces clavatus) M. clavatus (formerly Saprochaete capitata and Saprochaete clavata) infection diagnosed between January 2010 and December 2020 were recorded from the SEIFEM (Sorveglianza Epidemiologica Infezioni nelle Emopatie) group and FungiScope (Global Emerging Fungal Infection Registry). Cases of Magnusiomyces fungemia were compared with candidemia. Results Among 90 Magnusiomyces cases (60 [66%] M. capitatus and 30 (34%) M. clavatus), median age was 50 years (range 2-78), 46 patients (51%) were female and 67 (74%) had acute leukaemia. Thirty-six (40%) of Magnusiomyces-associated infections occurred during antifungal prophylaxis, mainly with posaconazole (n = 13, 36%) and echinocandins (n = 12, 34%). Instead, the candidemia rarely occurred during prophylaxis (p < .0001). First-line antifungal therapy with azoles, alone or in combination, was associated with improved response compared to other antifungals (p = .001). Overall day-30 mortality rate was 43%. Factors associated with higher mortality rates were septic shock (HR 2.696, 95% CI 1.396-5.204, p = .003), corticosteroid treatment longer than 14 days (HR 2.245, 95% CI 1.151-4.376, p = .018) and lack of neutrophil recovery (HR 3.997, 95% CI 2.102-7.601, p < .001). The latter was independently associated with poor outcome (HR 2.495, 95% CI 1.192-5.222, p = .015). Conclusions Magnusiomyces-associated infections are often breakthrough infections. Effective treatment regimens of these infections remain to be determined, but neutrophil recovery appears to play an important role in the favourable outcome.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Del Principe, Maria IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seidel, DanilaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Criscuolo, MariannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dargenio, MichelinaUNSPECIFIEDorcid.org/0000-0003-0924-4629UNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piedimonte, MonicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchesi, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nadali, GianpaoloUNSPECIFIEDorcid.org/0000-0002-0444-9644UNSPECIFIED
Koehler, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fracchiolla, NicolaUNSPECIFIEDorcid.org/0000-0002-8982-8079UNSPECIFIED
Cattaneo, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimko, NikolaiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spolzino, AngelicaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karapinar, Deniz YilmazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demiraslan, HayatiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duarte, Rafael F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demeter, JuditUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stanzani, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Melillo, Lorella Maria AntoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basilico, Claudia MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cesaro, SimoneUNSPECIFIEDorcid.org/0000-0002-8698-9547UNSPECIFIED
Paterno, GiovangiacintoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Califano, CatelloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delia, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buzzatti, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busca, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDorcid.org/0000-0001-9599-3137UNSPECIFIED
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alakel, NaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arsenijevi'c, Valentina Arsi'cUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Camus, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Itzhak, LevyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kouba, MichalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martino, RodrigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sedlacek, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinbergerova, BarboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698006
DOI: 10.1111/myc.13524
Journal or Publication Title: Mycoses
Volume: 66
Number: 1
Page Range: S. 35 - 47
Date: 2023
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1439-0507
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INVASIVE INFECTIONS; FUNGAL-INFECTION; HEMATOLOGICAL MALIGNANCIES; GEOTRICHUM; CAPITATUS; MANAGEMENT; DISEASES; CLAVATA; TRICHOSPORON; GUIDELINESMultiple languages
Dermatology; MycologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69800

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