Lescoat, Alain ORCID: 0000-0003-2081-8558, Huscher, Doerte, Schoof, Nils ORCID: 0000-0003-0509-9217, Airo, Paolo, De Vries-Bouwstra, Jeska, Riemekasten, Gabriela, Hachulla, Eric, Doria, Andrea ORCID: 0000-0003-0548-4983, Rosato, Edoardo, Hunzelmann, Nicolas, Montecucco, Carlomaurizio, Gabrielli, Armando, Hoffmann-Vold, Anna-Maria, Distler, Oliver, Ben Shimol, Jennifer ORCID: 0000-0003-1884-4925, Cutolo, Maurizio and Allanore, Yannick . Systemic sclerosis-associated interstitial lung disease in the EUSTAR database: analysis by region. RHEUMATOLOGY. OXFORD: OXFORD UNIV PRESS. ISSN 1462-0332

Full text not available from this repository.

Abstract

Objectives The prevalence and characteristics of SSc-associated interstitial lung disease (SSc-ILD) vary between geographical regions worldwide. The objectives of this study were to explore the differences in terms of prevalence, phenotype, treatment and prognosis in patients with SSc-ILD from predetermined geographical regions in the EUSTAR database. Material and methods Patients were clustered into seven geographical regions. Clinical characteristics and survival of patients with SSc-ILD were compared among these pre-determined regions. Results For baseline analyses, 9260 SSc patients were included, with 6732 for survival analyses. The prevalence of SSc-ILD in the overall population was 50.2%, ranging from 44.0% in 'Western Europe and Nordic countries' to 67.5% in 'Eastern European, Russia and Baltic countries'. In all regions, anti-topoisomerase antibodies were associated with SSc-ILD. Management also significantly differed; mycophenolate mofetil was prescribed at baseline in 31.6% of patients with SSc-ILD in 'America (North and South)' and 31.7% in 'Middle East' but only 4.3% in 'Asia and Oceania' (P <0.0001). Patients from 'America (North and South)' and 'Middle East' had the highest survival rate at the end of follow-up (85.8% and 85.2%, respectively). Conclusions Our study highlights key differences among regions in terms of clinical presentation and prognosis of SSc-ILD. This work also demonstrates that the management of SSc-ILD is highly variable among the different regions considered, suggesting that efforts are still needed for the standardization of medical practice in the treatment of this disease.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lescoat, AlainUNSPECIFIEDorcid.org/0000-0003-2081-8558UNSPECIFIED
Huscher, DoerteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoof, NilsUNSPECIFIEDorcid.org/0000-0003-0509-9217UNSPECIFIED
Airo, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Vries-Bouwstra, JeskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riemekasten, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hachulla, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Doria, AndreaUNSPECIFIEDorcid.org/0000-0003-0548-4983UNSPECIFIED
Rosato, EdoardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hunzelmann, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montecucco, CarlomaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gabrielli, ArmandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoffmann-Vold, Anna-MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Distler, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ben Shimol, JenniferUNSPECIFIEDorcid.org/0000-0003-1884-4925UNSPECIFIED
Cutolo, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allanore, YannickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698176
DOI: 10.1093/rheumatology/keac576
Journal or Publication Title: RHEUMATOLOGY
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1462-0332
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SCLERODERMA; AFRICAN; PROFILE; COHORT; STANDARDIZATION; CLASSIFICATION; AMERICANS; MORTALITY; FEATURES; SUBSETSMultiple languages
RheumatologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69817

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item