Mejia-Chew, Carlos, Carver, Peggy L., Rutjanawech, Sasinuch, Aranha Camargo, Luis F., Fernandes, Ruan ORCID: 0000-0001-5451-9578, Belga, Sara, Daniels, Shay Anne, Mueller, Nicolas J., Burkhard, Sara, Theodoropoulos, Nicole M., Postma, Douwe F., van Duijn, Pleun J., Carmen Farinas, Maria, Gonzalez-Rico, Claudia, Hand, Jonathan, Lowe, Adam, Bodro, Marta, Vanino, Elisa, Cruz, Ana Fernandez, Ramos, Antonio, Makek, Mateja Jankovic, Mjahed, Ribal Bou, Manuel, Oriol, Kamar, Nassim, Calvo-Cano, Antonia, Rueda Carrasco, Laura, Munoz, Patricia, Rodriguez, Sara, Perez-Recio, Sandra, Sabe, Nuria, Rodriguez Alvarez, Regino, Tiago Silva, Jose, Mularoni, Alessandra, Vidal, Elisa, Alonso-Titos, Juana, del Rosal, Teresa, Classen, Annika Y., Goss, Charles W., Agarwal, Mansi and Lopez-Medrano, Francisco . Risk Factors for Nontuberculous Mycobacteria Infections in Solid Organ Transplant Recipients: A Multinational Case-Control Study. Clin. Infect. Dis.. CARY: OXFORD UNIV PRESS INC. ISSN 1537-6591

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Abstract

Background Risk factors for nontuberculous mycobacteria (NTM) infections after solid organ transplant (SOT) are not well characterized. Here we aimed to describe these factors. Methods Retrospective, multinational, 1:2 matched case-control study that included SOT recipients >= 12 years old diagnosed with NTM infection from 1 January 2008 to 31 December 2018. Controls were matched on transplanted organ, NTM treatment center, and post-transplant survival greater than or equal to the time to NTM diagnosis. Logistic regression on matched pairs was used to assess associations between risk factors and NTM infections. Results Analyses included 85 cases and 169 controls (59% male, 88% White, median age at time of SOT of 54 years [interquartile range {IQR} 40-62]). NTM infection occurred in kidney (42%), lung (35%), heart and liver (11% each), and pancreas transplant recipients (1%). Median time from transplant to infection was 21.6 months (IQR 5.3-55.2). Most underlying comorbidities were evenly distributed between groups; however, cases were older at the time of NTM diagnosis, more frequently on systemic corticosteroids and had a lower lymphocyte count (all P < .05). In the multivariable model, older age at transplant (adjusted odds ratio [aOR] 1.04; 95 confidence interval [CI], 1.01-1.07), hospital admission within 90 days (aOR, 3.14; 95% CI, 1.41-6.98), receipt of antifungals (aOR, 5.35; 95% CI, 1.7-16.91), and lymphocyte-specific antibodies (aOR, 7.73; 95% CI, 1.07-56.14), were associated with NTM infection. Conclusions Risk of NTM infection in SOT recipients was associated with older age at SOT, prior hospital admission, receipt of antifungals or lymphocyte-specific antibodies. NTM infection should be considered in SOT patients with these risk factors. In this multinational, 1:2 matched case-control study of solid organ transplant (SOT) recipients, older age at transplantation; and hospital admission, receipt of antifungals or lymphocyte-specific antibodies within 90 days of nontuberculous mycobacteria (NTM) disease were associated with increased odds of disease in the multivariable model.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mejia-Chew, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carver, Peggy L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rutjanawech, SasinuchUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aranha Camargo, Luis F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandes, RuanUNSPECIFIEDorcid.org/0000-0001-5451-9578UNSPECIFIED
Belga, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Daniels, Shay AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Nicolas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burkhard, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Theodoropoulos, Nicole M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Postma, Douwe F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Duijn, Pleun J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carmen Farinas, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Rico, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hand, JonathanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lowe, AdamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bodro, MartaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanino, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz, Ana FernandezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramos, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makek, Mateja JankovicUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mjahed, Ribal BouUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Manuel, OriolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamar, NassimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calvo-Cano, AntoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueda Carrasco, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munoz, PatriciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Recio, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sabe, NuriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez Alvarez, ReginoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tiago Silva, JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mularoni, AlessandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, ElisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alonso-Titos, JuanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
del Rosal, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Classen, Annika Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goss, Charles W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Agarwal, MansiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Medrano, FranciscoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698181
DOI: 10.1093/cid/ciac608
Journal or Publication Title: Clin. Infect. Dis.
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1537-6591
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LUNG-DISEASE; PREVALENCE; DIAGNOSIS; PREDICTS; KIDNEYMultiple languages
Immunology; Infectious Diseases; MicrobiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69818

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