Kleineidam, Luca, Wolfsgruber, Steffen, Weyrauch, Anne-Sophie, Zulka, Linn E., Forstmeier, Simon, Roeske, Sandra, van den Bussche, Hendrik, Kaduszkiewicz, Hanna, Wiese, Birgitt, Weyerer, Siegfried, Werle, Jochen, Fuchs, Angela, Pentzek, Michael, Brettschneider, Christian ORCID: 0000-0002-5280-1075, Konig, Hans-Helmut, Weeg, Dagmar, Bickel, Horst, Luppa, Melanie ORCID: 0000-0003-3927-6728, Rodriguez, Francisca S., Freiesleben, Silka Dawn, Erdogan, Selin, Unterfeld, Chantal, Peters, Oliver ORCID: 0000-0003-0568-2998, Spruth, Eike J., Altenstein, Slawek, Lohse, Andrea, Priller, Josef, Fliessbach, Klaus, Kobeleva, Xenia, Schneider, Anja ORCID: 0000-0001-9540-8700, Bartels, Claudia, Schott, Bjoern H., Wiltfang, Jens, Maier, Franziska ORCID: 0000-0002-9335-9594, Glanz, Wenzel, Incesoy, Enise I., Butryn, Michaela, Duezel, Emrah, Buerger, Katharina, Janowitz, Daniel, Ewers, Michael, Rauchmann, Boris-Stephan ORCID: 0000-0003-4547-6240, Perneczky, Robert, Kilimann, Ingo, Goerss, Doreen, Teipel, Stefan, Laske, Christoph, Munk, Matthias H. J., Spottke, Annika, Roy, Nina, Brosseron, Frederic, Heneka, Michael T., Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Yakupov, Renat, Scherer, Martin, Maier, Wolfgang, Jessen, Frank, Riedel-Heller, Steffi G. and Wagner, Michael (2022). Midlife occupational cognitive requirements protect cognitive function in old age by increasing cognitive reserve. Front. Psychol., 13. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-1078

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Abstract

IntroductionSeveral lifestyle factors promote protection against Alzheimer's disease (AD) throughout a person's lifespan. Although such protective effects have been described for occupational cognitive requirements (OCR) in midlife, it is currently unknown whether they are conveyed by brain maintenance (BM), brain reserve (BR), or cognitive reserve (CR) or a combination of them. MethodsWe systematically derived hypotheses for these resilience concepts and tested them in the population-based AgeCoDe cohort and memory clinic-based AD high-risk DELCODE study. The OCR score (OCRS) was measured using job activities based on the O*NET occupational classification system. Four sets of analyses were conducted: (1) the interaction of OCR and APOE-epsilon 4 with regard to cognitive decline (N = 2,369, AgeCoDe), (2) association with differentially shaped retrospective trajectories before the onset of dementia of the Alzheimer's type (DAT; N = 474, AgeCoDe), (3) cross-sectional interaction of the OCR and cerebrospinal fluid (CSF) AD biomarkers and brain structural measures regarding memory function (N = 873, DELCODE), and (4) cross-sectional and longitudinal association of OCR with CSF AD biomarkers and brain structural measures (N = 873, DELCODE). ResultsRegarding (1), higher OCRS was associated with a reduced association of APOE-epsilon 4 with cognitive decline (mean follow-up = 6.03 years), consistent with CR and BR. Regarding (2), high OCRS was associated with a later onset but subsequently stronger cognitive decline in individuals converting to DAT, consistent with CR. Regarding (3), higher OCRS was associated with a weaker association of the CSF A beta 42/40 ratio and hippocampal volume with memory function, consistent with CR. Regarding (4), OCR was not associated with the levels or changes in CSF AD biomarkers (mean follow-up = 2.61 years). We found a cross-sectional, age-independent association of OCRS with some MRI markers, but no association with 1-year-change. OCR was not associated with the intracranial volume. These results are not completely consistent with those of BR or BM. DiscussionOur results support the link between OCR and CR. Promoting and seeking complex and stimulating work conditions in midlife could therefore contribute to increased resistance to pathologies in old age and might complement prevention measures aimed at reducing pathology.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolfsgruber, SteffenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyrauch, Anne-SophieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zulka, Linn E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forstmeier, SimonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roeske, SandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Bussche, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaduszkiewicz, HannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiese, BirgittUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weyerer, SiegfriedUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Werle, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fuchs, AngelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pentzek, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brettschneider, ChristianUNSPECIFIEDorcid.org/0000-0002-5280-1075UNSPECIFIED
Konig, Hans-HelmutUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weeg, DagmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bickel, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luppa, MelanieUNSPECIFIEDorcid.org/0000-0003-3927-6728UNSPECIFIED
Rodriguez, Francisca S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freiesleben, Silka DawnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erdogan, SelinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Unterfeld, ChantalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDorcid.org/0000-0003-0568-2998UNSPECIFIED
Spruth, Eike J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Altenstein, SlawekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohse, AndreaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobeleva, XeniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Bartels, ClaudiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schott, Bjoern H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, FranziskaUNSPECIFIEDorcid.org/0000-0002-9335-9594UNSPECIFIED
Glanz, WenzelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Incesoy, Enise I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Butryn, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Janowitz, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ewers, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rauchmann, Boris-StephanUNSPECIFIEDorcid.org/0000-0003-4547-6240UNSPECIFIED
Perneczky, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goerss, DoreenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laske, ChristophUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Munk, Matthias H. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roy, NinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Yakupov, RenatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698376
DOI: 10.3389/fpsyg.2022.957308
Journal or Publication Title: Front. Psychol.
Volume: 13
Date: 2022
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 1664-1078
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ALZHEIMERS-DISEASE; HIPPOCAMPAL ATROPHY; ACCELERATED DECLINE; LEISURE ACTIVITY; EPISODIC MEMORY; EDUCATION; DEMENTIA; RISK; COMPLEXITY; BRAINMultiple languages
Psychology, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69837

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