de By, Theo M. M. H., Schoenrath, Felix, Veen, Kevin M., Mohacsi, Paul, Stein, Julia, Alkhamees, Khalid M. M., Anastasiadis, Kyriakos ORCID: 0000-0001-7837-3446, Berhnardt, Alexander, Beyersdorf, Friedhelm ORCID: 0000-0003-2975-2751, Caliskan, Kadir ORCID: 0000-0002-3293-9261, Reineke, David, Damman, Kevin, Fiane, Arnt, Gkouziouta, Angeliki, Gollmann-Tepekoeylue, Can, Finn, Gustafsson, Hulman, Michal, Iacovoni, Attilio, Loforte, Antonio ORCID: 0000-0002-3689-0477, Merkely, Bela, Musumeci, Francesco, Nemec, Petr, Netuka, Ivan, Ozbaran, Mustafa, Potapov, Evgenij, Pya, Yuri, Rabago, Gregorio, Ramjankhan, Faiz, Reichenspurner, Hermann, Saeed, Diyar, Sandoval, Elena, Stockman, Bernard, Vanderheyden, Marc, Tops, Laurens, Wahlers, Thorsten, Zembala, Michael, Zimpfer, Daniel, Carrel, Thierry, Gummert, Jan and Meyns, Bart (2022). The European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery: third report. Eur. J. Cardio-Thorac. Surg., 62 (1). CARY: OXFORD UNIV PRESS INC. ISSN 1873-734X

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Abstract

OBJECTIVES In the third report of the European Registry for Patients with Mechanical Circulatory Support of the European Association for Cardio-Thoracic Surgery, outcomes of patients receiving mechanical circulatory support are reviewed in relation to implant era. METHODS Procedures in adult patients (January 2011-June 2020) were included. Patients from centres with <60% follow-ups completed were excluded. Outcomes were stratified into 3 eras (2011-2013, 2014-2017 and 2018-2020). Adverse event rates (AERs) were calculated and stratified into early phase (<3 months) and late phase (>3 months). Risk factors for death were explored using univariable Cox regression with a stepwise time-varying hazard ratio (3 months). RESULTS In total, 4834 procedures in 4486 individual patients (72 hospitals) were included, with a median follow-up of 1.1 (interquartile range: 0.3-2.6) years. The annual number of implants (range: 346-600) did not significantly change (P = 0.41). Both Interagency Registry for Mechanically Assisted Circulatory Support class (classes 4-7: 23, 25 and 33%; P < 0.001) and in-hospital deaths (18.5, 17.2 and 11.2; P < 0.001) decreased significantly between eras. Overall, mortality, transplants and the probability of weaning were 55, 25 and 2% at 5 years after the implant, respectively. Major infections were mainly noted early after the implant occurred (AER(3 months): 0.45). Bilirubin and creatinine levels were significant risk factors in the early phase but not in the late phase after the implant. CONCLUSIONS In its 10 years of existence, EUROMACS has become a point of reference enabling benchmarking and outcome monitoring. Patient characteristics and outcomes changed between implant eras. In addition, both occurrence of outcomes and risk factor weights are time dependent. As a registry of the European Association for Cardio-Thoracic Surgery, the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) offers a robust repository of clinical data on long-term mechanical circulatory support (MCS) from a large international community.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
de By, Theo M. M. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenrath, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Veen, Kevin M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mohacsi, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alkhamees, Khalid M. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anastasiadis, KyriakosUNSPECIFIEDorcid.org/0000-0001-7837-3446UNSPECIFIED
Berhnardt, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beyersdorf, FriedhelmUNSPECIFIEDorcid.org/0000-0003-2975-2751UNSPECIFIED
Caliskan, KadirUNSPECIFIEDorcid.org/0000-0002-3293-9261UNSPECIFIED
Reineke, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Damman, KevinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fiane, ArntUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gkouziouta, AngelikiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gollmann-Tepekoeylue, CanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Finn, GustafssonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hulman, MichalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacovoni, AttilioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Loforte, AntonioUNSPECIFIEDorcid.org/0000-0002-3689-0477UNSPECIFIED
Merkely, BelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Musumeci, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nemec, PetrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Netuka, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ozbaran, MustafaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Potapov, EvgenijUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pya, YuriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabago, GregorioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramjankhan, FaizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reichenspurner, HermannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saeed, DiyarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sandoval, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stockman, BernardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vanderheyden, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tops, LaurensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wahlers, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zembala, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zimpfer, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrel, ThierryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gummert, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meyns, BartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-698532
DOI: 10.1093/ejcts/ezac032
Journal or Publication Title: Eur. J. Cardio-Thorac. Surg.
Volume: 62
Number: 1
Date: 2022
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1873-734X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
VENTRICULAR ASSIST DEVICE; CUMULATIVE INCIDENCE; OUTCOMES; SOCIETY; EVENTSMultiple languages
Cardiac & Cardiovascular Systems; Respiratory System; SurgeryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69853

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