von Reumont, Bjoern M., Anderluh, Gregor, Antunes, Agostinho, Ayvazyan, Naira, Beis, Dimitris, Caliskan, Figen, Crnkovic, Ana ORCID: 0000-0002-0581-1887, Damm, Maik ORCID: 0000-0003-0810-3699, Dutertre, Sebastien, Ellgaard, Lars ORCID: 0000-0002-7018-0137, Gajski, Goran, German, Hannah, Halassy, Beata, Hempel, Benjamin-Florian ORCID: 0000-0002-1998-4033, Hucho, Tim ORCID: 0000-0002-4147-9308, Igci, Nasit, Ikonomopoulou, Maria P., Karbat, Izhar, Klapa, Maria, I, Koludarov, Ivan, Kool, Jeroen, Lueddecke, Tim, Ben Mansour, Riadh, Modica, Maria Vittoria, Moran, Yehu, Nalbantsoy, Ayse, Pachon Ibanez, Maria Eugenia, Panagiotopoulos, Alexios, Reuveny, Eitan, Sanchez Cespedes, Javier, Sombke, Andy ORCID: 0000-0001-7383-440X, Surm, Joachim M., Undheim, Eivind A. B., Verdes, Aida ORCID: 0000-0002-9193-9253 and Zancolli, Giulia ORCID: 0000-0003-3060-2507 (2022). Modern venomics-Current insights, novel methods, and future perspectives in biological and applied animal venom research. GigaScience, 11. OXFORD: OXFORD UNIV PRESS. ISSN 2047-217X

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Abstract

Venoms have evolved >100 times in all major animal groups, and their components, known as toxins, have been fine-tuned over millions of years into highly effective biochemical weapons. There are many outstanding questions on the evolution of toxin arsenals, such as how venom genes originate, how venom contributes to the fitness of venomous species, and which modifications at the genomic, transcriptomic, and protein level drive their evolution. These questions have received particularly little attention outside of snakes, cone snails, spiders, and scorpions. Venom compounds have further become a source of inspiration for translational research using their diverse bioactivities for various applications. We highlight here recent advances and new strategies in modern venomics and discuss how recent technological innovations and multi-omic methods dramatically improve research on venomous animals. The study of genomes and their modifications through CRISPR and knockdown technologies will increase our understanding of how toxins evolve and which functions they have in the different ontogenetic stages during the development of venomous animals. Mass spectrometry imaging combined with spatial transcriptomics, in situ hybridization techniques, and modern computer tomography gives us further insights into the spatial distribution of toxins in the venom system and the function of the venom apparatus. All these evolutionary and biological insights contribute to more efficiently identify venom compounds, which can then be synthesized or produced in adapted expression systems to test their bioactivity. Finally, we critically discuss recent agrochemical, pharmaceutical, therapeutic, and diagnostic (so-called translational) aspects of venoms from which humans benefit.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
von Reumont, Bjoern M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anderluh, GregorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Antunes, AgostinhoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ayvazyan, NairaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beis, DimitrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caliskan, FigenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Crnkovic, AnaUNSPECIFIEDorcid.org/0000-0002-0581-1887UNSPECIFIED
Damm, MaikUNSPECIFIEDorcid.org/0000-0003-0810-3699UNSPECIFIED
Dutertre, SebastienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ellgaard, LarsUNSPECIFIEDorcid.org/0000-0002-7018-0137UNSPECIFIED
Gajski, GoranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
German, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Halassy, BeataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hempel, Benjamin-FlorianUNSPECIFIEDorcid.org/0000-0002-1998-4033UNSPECIFIED
Hucho, TimUNSPECIFIEDorcid.org/0000-0002-4147-9308UNSPECIFIED
Igci, NasitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ikonomopoulou, Maria P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karbat, IzharUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klapa, Maria, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koludarov, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kool, JeroenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lueddecke, TimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ben Mansour, RiadhUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Modica, Maria VittoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moran, YehuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nalbantsoy, AyseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pachon Ibanez, Maria EugeniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panagiotopoulos, AlexiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reuveny, EitanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez Cespedes, JavierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sombke, AndyUNSPECIFIEDorcid.org/0000-0001-7383-440XUNSPECIFIED
Surm, Joachim M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Undheim, Eivind A. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verdes, AidaUNSPECIFIEDorcid.org/0000-0002-9193-9253UNSPECIFIED
Zancolli, GiuliaUNSPECIFIEDorcid.org/0000-0003-3060-2507UNSPECIFIED
URN: urn:nbn:de:hbz:38-698600
DOI: 10.1093/gigascience/giac048
Journal or Publication Title: GigaScience
Volume: 11
Date: 2022
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 2047-217X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TOP-DOWN PROTEOMICS; MASS-SPECTROMETRY; GENE-EXPRESSION; ION CHANNELS; FUNCTIONAL-MORPHOLOGY; BEE VENOM; FIRE ANT; TOXINS; SPIDER; EVOLUTIONMultiple languages
Biology; Multidisciplinary SciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69860

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