Le Rhun, Emilie, Devos, Patrick ORCID: 0000-0001-7803-9552, Winklhofer, Sebastian, Lmalen, Hafida, Brandsma, Dieta, Kumthekar, Priya, Castellano, Antonella ORCID: 0000-0002-4137-9016, Compter, Annette, Dhermain, Frederic, Franceschi, Enrico, Forsyth, Peter, Furtner, Julia, Galldiks, Norbert, Perez-Larraya, Jaime Gallego, Gempt, Jens, Hattingen, Elke, Hempel, Johann Martin, Lukacova, Slavka, Minniti, Giuseppe, O'Brien, Barbara, Postma, Tjeerd J., Roth, Patrick ORCID: 0000-0003-3897-214X, Ruda, Roberta, Schaefer, Niklas, Schmidt, Nils O., Snijders, Tom J., Thust, Steffi, van den Bent, Martin, van der Hoorn, Anouk ORCID: 0000-0003-4649-327X, Vogin, Guillaume ORCID: 0000-0002-8114-5900, Smits, Marion ORCID: 0000-0001-5563-2871, Tonn, Joerg C., Jaeckle, Kurt, Preusser, Matthias ORCID: 0000-0003-3541-2315, Glantz, Michael, Wen, Patrick Y., Bendzsus, Martin and Weller, Michael ORCID: 0000-0002-1748-174X (2022). Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: A joint EORTC BTG and RANO effort. Neuro-Oncology, 24 (10). S. 1726 - 1736. CARY: OXFORD UNIV PRESS INC. ISSN 1523-5866

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Abstract

Background Validation of the 2016 RANO MRI scorecard for leptomeningeal metastasis failed for multiple reasons. Accordingly, this joint EORTC Brain Tumor Group and RANO effort sought to prospectively validate a revised MRI scorecard for response assessment in leptomeningeal metastasis. Methods Coded paired cerebrospinal MRI of 20 patients with leptomeningeal metastases from solid cancers at baseline and follow-up after treatment and instructions for assessment were provided via the EORTC imaging platform. The Kappa coefficient was used to evaluate the interobserver pairwise agreement. Results Thirty-five raters participated, including 9 neuroradiologists, 17 neurologists, 4 radiation oncologists, 3 neurosurgeons, and 2 medical oncologists. Among single leptomeningeal metastases-related imaging findings at baseline, the best median concordance was noted for hydrocephalus (Kappa = 0.63), and the worst median concordance for spinal linear enhancing disease (Kappa = 0.46). The median concordance of raters for the overall response assessment was moderate (Kappa = 0.44). Notably, the interobserver agreement for the presence of parenchymal brain metastases at baseline was fair (Kappa = 0.29) and virtually absent for their response to treatment. 394 of 700 ratings (20 patients x 35 raters, 56%) were fully completed. In 308 of 394 fully completed ratings (78%), the overall response assessment perfectly matched the summary interpretation of the single ratings as proposed in the scorecard instructions. Conclusion This study confirms the principle utility of the new scorecard, but also indicates the need for training of MRI assessment with a dedicated reviewer panel in clinical trials. Electronic case report forms with blocking options may be required to enforce completeness and quality of scoring.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Le Rhun, EmilieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devos, PatrickUNSPECIFIEDorcid.org/0000-0001-7803-9552UNSPECIFIED
Winklhofer, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lmalen, HafidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brandsma, DietaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kumthekar, PriyaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castellano, AntonellaUNSPECIFIEDorcid.org/0000-0002-4137-9016UNSPECIFIED
Compter, AnnetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dhermain, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franceschi, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Forsyth, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Furtner, JuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Galldiks, NorbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perez-Larraya, Jaime GallegoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gempt, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hattingen, ElkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hempel, Johann MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lukacova, SlavkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Minniti, GiuseppeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Brien, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Postma, Tjeerd J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roth, PatrickUNSPECIFIEDorcid.org/0000-0003-3897-214XUNSPECIFIED
Ruda, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaefer, NiklasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, Nils O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Snijders, Tom J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thust, SteffiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van den Bent, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Hoorn, AnoukUNSPECIFIEDorcid.org/0000-0003-4649-327XUNSPECIFIED
Vogin, GuillaumeUNSPECIFIEDorcid.org/0000-0002-8114-5900UNSPECIFIED
Smits, MarionUNSPECIFIEDorcid.org/0000-0001-5563-2871UNSPECIFIED
Tonn, Joerg C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaeckle, KurtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Preusser, MatthiasUNSPECIFIEDorcid.org/0000-0003-3541-2315UNSPECIFIED
Glantz, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wen, Patrick Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bendzsus, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weller, MichaelUNSPECIFIEDorcid.org/0000-0002-1748-174XUNSPECIFIED
URN: urn:nbn:de:hbz:38-699158
DOI: 10.1093/neuonc/noac043
Journal or Publication Title: Neuro-Oncology
Volume: 24
Number: 10
Page Range: S. 1726 - 1736
Date: 2022
Publisher: OXFORD UNIV PRESS INC
Place of Publication: CARY
ISSN: 1523-5866
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CONSENSUS RECOMMENDATIONS; PROTOCOLMultiple languages
Oncology; Clinical NeurologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69915

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