Waszczuk-Gajda, Anna ORCID: 0000-0001-5626-1750, Penack, Olaf, Sbianchi, Giulia, Koster, Linda, Blaise, Didier ORCID: 0000-0002-5684-9447, Remenyi, Peter, Russell, Nigel, Ljungman, Per ORCID: 0000-0002-8281-3245, Trneny, Marek ORCID: 0000-0002-6952-6073, Mayer, Jiri, Iacobelli, Simona, Kobbe, Guido, Scheid, Christof, Apperley, Jane, Touzeau, Cyrille ORCID: 0000-0003-0275-2575, Lenhoff, Stig, Jantunen, Esa, Anagnostopoulos, Achilles ORCID: 0000-0003-4384-9031, Paris, Laura, Browne, Paul, Thieblemont, Catherine, Schaap, Nicolaas ORCID: 0000-0001-7696-4752, Sierra, Jorge, Yakoub-Agha, Ibrahim ORCID: 0000-0003-4524-8782, Garderet, Laurent, Styczynski, Jan, Schoemans, Helene ORCID: 0000-0002-7568-8239, Moiseev, Ivan, Duarte, Rafael F., Peric, Zinaida, Montoto, Silvia ORCID: 0000-0002-3006-9725, van Biezen, Anja, Mikulska, Malgorzata, Aljurf, Mahmoud, Ruutu, Tapani, Kroeger, Nicolaus, Morris, Curly, Koenecke, Christian, Schoenland, Stefan and Basak, Grzegorz W. (2022). Complications of Autologous Stem Cell Transplantation in Multiple Myeloma: Results from the CALM Study. J. Clin. Med., 11 (12). BASEL: MDPI. ISSN 2077-0383

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Abstract

Background: The main goal of this post hoc analysis of the Collaboration to Collect Autologous Transplant Outcomes in Lymphoma and Myeloma (CALM) study was to evaluate the rate of short- and long-term infectious and non-infectious complications occurring after ASCT in patients with multiple myeloma (MM). Methods: The analysis included all patients with MM from the CALM study who underwent >= 1 ASCT. The primary endpoint of the analysis was to determine the rate of infectious and non-infectious complications after ASCT and to compare them in three time periods: 0-100 days, 101 days-1 year, and >1 year after the first transplant. Results: The analysis included a total of 3552 patients followed up for a median of 56.7 months (range 0.4-108.1). Complication rates decreased with the time from ASCT with 24.85 cases per 100 patient-years from day 0 to 100 days after the transplant, and <2.31 cases per 100 patient-years from the 101st day. At 100 days after ASC T, 45.7% of patients had complications, with infectious events being twice as frequent as non-infectious complications. Bacterial infections (6.5 cases per 100 patient-years, 95% CI: 6.1-7.0) and gastrointestinal complications (4.7 cases per 100 patient-years, 95% CI: 4.3-5.1) were the most common early events. The pattern of complications changed with time from ASCT. The presence of complications after ASCT was not associated with overall survival. Conclusions: Our data provide a solid basis for comparing ASCT-related complications to those caused by emerging treatments in multiple myeloma, such as CAR T-cell therapy and other immunotherapies.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Waszczuk-Gajda, AnnaUNSPECIFIEDorcid.org/0000-0001-5626-1750UNSPECIFIED
Penack, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sbianchi, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koster, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blaise, DidierUNSPECIFIEDorcid.org/0000-0002-5684-9447UNSPECIFIED
Remenyi, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Russell, NigelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ljungman, PerUNSPECIFIEDorcid.org/0000-0002-8281-3245UNSPECIFIED
Trneny, MarekUNSPECIFIEDorcid.org/0000-0002-6952-6073UNSPECIFIED
Mayer, JiriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iacobelli, SimonaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kobbe, GuidoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheid, ChristofUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Apperley, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Touzeau, CyrilleUNSPECIFIEDorcid.org/0000-0003-0275-2575UNSPECIFIED
Lenhoff, StigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jantunen, EsaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anagnostopoulos, AchillesUNSPECIFIEDorcid.org/0000-0003-4384-9031UNSPECIFIED
Paris, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Browne, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thieblemont, CatherineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schaap, NicolaasUNSPECIFIEDorcid.org/0000-0001-7696-4752UNSPECIFIED
Sierra, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yakoub-Agha, IbrahimUNSPECIFIEDorcid.org/0000-0003-4524-8782UNSPECIFIED
Garderet, LaurentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Styczynski, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoemans, HeleneUNSPECIFIEDorcid.org/0000-0002-7568-8239UNSPECIFIED
Moiseev, IvanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duarte, Rafael F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peric, ZinaidaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Montoto, SilviaUNSPECIFIEDorcid.org/0000-0002-3006-9725UNSPECIFIED
van Biezen, AnjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mikulska, MalgorzataUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aljurf, MahmoudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruutu, TapaniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroeger, NicolausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, CurlyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenecke, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoenland, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Basak, Grzegorz W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699164
DOI: 10.3390/jcm11123541
Journal or Publication Title: J. Clin. Med.
Volume: 11
Number: 12
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2077-0383
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
INFECTIONS; LYMPHOMA; BLOOD; ERAMultiple languages
Medicine, General & InternalMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69916

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