Kroese, Tiuri E. ORCID: 0000-0002-5569-4164, van Hillegersberg, Richard, Schoppmann, Sebastian, Deseyne, Pieter R. A. J., Nafteux, Philippe, Obermannova, Radka, Nordsmark, Marianne, Pfeiffer, Per ORCID: 0000-0002-2925-0586, Hawkins, Maria A., Smyth, Elizabeth, Markar, Sheraz, Hanna, George B., Cheong, Edward, Chaudry, Asif, Elme, Anneli, Adenis, Antoine, Piessen, Guillaume, Gani, Cihan, Bruns, Christiane J., Moehler, Markus, Liakakos, Theodore, Reynolds, John, Morganti, Alessio, Rosati, Riccardo, Castoro, Carlo ORCID: 0000-0001-9601-9336, D'Ugo, Domenico, Roviello, Franco, Bencivenga, Maria, de Manzoni, Giovanni, Jeene, Paul, van Sandick, Johanna W., Muijs, Christel, Slingerland, Marije, Nieuwenhuijzen, Grard, Wijnhoven, Bas, Beerepoot, Laurens, V, Kolodziejczyk, Piotr, Polkowski, Wojciech P., Alsina, Maria, Pera, Manuel, Kanonnikoff, Tania F., Nilsson, Magnus, Guckenberger, Matthias ORCID: 0000-0002-7146-9071, Monig, Stefan, Wagner, Dorethea, Wyrwicz, Lucjan, Berbee, Maaike, Gockel, Ines, Lordick, Florian, Griffiths, Ewen A., Verheij, Marcel, van Rossum, Peter S. N. and van Laarhoven, Hanneke W. M. (2022). Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe. Eur. J. Cancer, 164. S. 18 - 30. OXFORD: ELSEVIER SCI LTD. ISSN 1879-0852

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Abstract

Background: Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking. Objective: To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary tumour boards (MDTs) in Europe. Material and methods: European expert centers (n Z 49) were requested to discuss 15 real-life cases in their MDT with at least a medical, surgical, and radiation oncologist present. The cases varied in terms of location and number of metastases, histology, timing of detection (i.e. synchronous versus metachronous), primary tumour treatment status, and response to systemic therapy. The primary outcome was the agreement in the definition of oligometastatic disease at diagnosis and after systemic therapy. The secondary outcome was the agreement in treatment strategies. Treatment strategies for oligometastatic disease were categorised into up -front local treatment (i.e. metastasectomy or stereotactic radiotherapy), systemic therapy followed by restaging to consider local treatment or systemic therapy alone. The agreement across MDTs was scored to be either absent/poor (< 50%), fair (50%-75%), or consensus (>= 75%). Results: A total of 47 MDTs across 16 countries fully discussed the cases (96%). Oligometastatic disease was considered in patients with 1-2 metastases in either the liver, lung, retroperitoneal lymph nodes, adrenal gland, soft tissue or bone (consensus). At follow-up, oligometastatic disease was considered after a median of 18 weeks of systemic therapy when no progression or progression in size only of the oligometastatic lesion(s) was seen (consensus). If at restaging after a median of 18 weeks of systemic therapy the number of lesions progressed, this was not considered as oligometastatic disease (fair agreement). There was no consensus on treatment strategies for oligometastatic disease. Conclusion: A broad consensus on definitions of oligometastatic oesophagogastric cancer was found among MDTs of oesophagogastric cancer expert centres in Europe. However, high practice variability in treatment strategies exists. (C) 2022 The Authors. Published by Elsevier Ltd.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Kroese, Tiuri E.UNSPECIFIEDorcid.org/0000-0002-5569-4164UNSPECIFIED
van Hillegersberg, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schoppmann, SebastianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deseyne, Pieter R. A. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nafteux, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Obermannova, RadkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordsmark, MarianneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfeiffer, PerUNSPECIFIEDorcid.org/0000-0002-2925-0586UNSPECIFIED
Hawkins, Maria A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smyth, ElizabethUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Markar, SherazUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanna, George B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cheong, EdwardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chaudry, AsifUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Elme, AnneliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adenis, AntoineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piessen, GuillaumeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gani, CihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, Christiane J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Moehler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Liakakos, TheodoreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reynolds, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morganti, AlessioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rosati, RiccardoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Castoro, CarloUNSPECIFIEDorcid.org/0000-0001-9601-9336UNSPECIFIED
D'Ugo, DomenicoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roviello, FrancoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bencivenga, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Manzoni, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jeene, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Sandick, Johanna W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muijs, ChristelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Slingerland, MarijeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nieuwenhuijzen, GrardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wijnhoven, BasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beerepoot, Laurens, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kolodziejczyk, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polkowski, Wojciech P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alsina, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pera, ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanonnikoff, Tania F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nilsson, MagnusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guckenberger, MatthiasUNSPECIFIEDorcid.org/0000-0002-7146-9071UNSPECIFIED
Monig, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, DoretheaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wyrwicz, LucjanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berbee, MaaikeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gockel, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lordick, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Griffiths, Ewen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verheij, MarcelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Rossum, Peter S. N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Laarhoven, Hanneke W. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699237
DOI: 10.1016/j.ejca.2021.11.032
Journal or Publication Title: Eur. J. Cancer
Volume: 164
Page Range: S. 18 - 30
Date: 2022
Publisher: ELSEVIER SCI LTD
Place of Publication: OXFORD
ISSN: 1879-0852
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SURGICAL RESECTION; SURVIVAL; CHEMOTHERAPY; JUNCTIONMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69923

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