Infante, Maria Stefania, Salmanton-Garcia, Jon, Fernandez-Cruz, Ana, Marchesi, Francesco, Jaksic, Ozren, Weinbergerova, Barbora, Besson, Caroline, Duarte, Rafael F., Itri, Federico ORCID: 0000-0002-3532-5281, Valkovic, Toni, Szotkovski, Tomas, Busca, Alessandro, Guidetti, Anna, Glenthoj, Andreas ORCID: 0000-0003-2082-0738, Collins, Graham P., Bonuomo, Valentina, Sili, Uluhan, Seval, Guldane Cengiz, Machado, Marina ORCID: 0000-0002-8370-2248, Cordoba, Raul, Blennow, Ola ORCID: 0000-0002-7167-7882, Abu-Zeinah, Ghaith, Lamure, Sylvain ORCID: 0000-0001-5980-305X, Kulasekararaj, Austin, Falces-Romero, Iker, Cattaneo, Chiara, Van Doesum, Jaap, Piukovics, Klara, Omrani, Ali S., Magliano, Gabriele, Ledoux, Marie-Pierre, de Ramon, Cristina, Cabirta, Alba, Verga, Luisa, Lopez-Garcia, Alberto, Da Silva, Maria Gomes, Stojanoski, Zlate, Meers, Stef, Lahmer, Tobias, Martin-Perez, Sonia, Davila-Vals, Julio, Van Praet, Jens, Samarkos, Michail, Bilgin, Yavuz M., Karlsson, Linda Katharina, Batinic, Josip, Nordlander, Anna, Schonlein, Martin, Hoenigl, Martin, Racil, Zdenek, Mladenovic, Milos, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, De Jonge, Nick, Adzic-Vukicevic, Tatjana, Nunes-Rodrigues, Raquel, Prezioso, Lucia, Navratil, Milan ORCID: 0000-0002-2067-1253, Marchetti, Monia, Cuccaro, Annarosa, Calbacho, Maria, Giordano, Antonio ORCID: 0000-0001-7143-6758, Cornely, Oliver A., Hernandez-Rivas, Jose-Angel ORCID: 0000-0003-4550-757X and Pagano, Livio (2022). B-cell malignancies treated with targeted drugs and SARS-CoV-2 infection: A European Hematology Association Survey (EPICOVIDEHA). Front. Oncol., 12. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

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Abstract

Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated with targeted drugs and laboratory-confirmed COVID-19 diagnosed between February 2020 and January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used targeted drugs were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than rituximab (N=61, 16%), BCL2 inhibitors (N=33, 9%) and lenalidomide (N=28, 8%).Only 16.2% of the patients were vaccinated with 2 or more doses of vaccine at the onset of COVID-19. Mortality was 24% (89/366) on day 30 and 36%(134/366) on the last day of follow-up. Age >75 years (p<0.001, HR 1.036), active malignancy (p<0.001, HR 2.215), severe COVID-19 (p=0.017, HR 2.270) and admission to ICU (p<0.001, HR 5.751) were risk factors for mortality at last day of follow up. There was no difference in OS rates in NHL vs CLL patients (p=0.306), nor in patients treated with or without BKIs (p=0.151). Mortality in ICU was 66% (CLL 61%, NHL 76%). Overall mortality rate decreased according to vaccination status, being 39% in unvaccinated patients, 32% and 26% in those having received one or two doses, respectively, and 20% in patients with a booster dose (p=0.245). Overall mortality rate dropped from 41% during the first semester of 2020 to 25% at the last semester of 2021. These results show increased severity and mortality from COVID-19 in LPDs patients treated with targeted drugs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Infante, Maria StefaniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmanton-Garcia, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez-Cruz, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchesi, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaksic, OzrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinbergerova, BarboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besson, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duarte, Rafael F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Itri, FedericoUNSPECIFIEDorcid.org/0000-0002-3532-5281UNSPECIFIED
Valkovic, ToniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szotkovski, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busca, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guidetti, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, AndreasUNSPECIFIEDorcid.org/0000-0003-2082-0738UNSPECIFIED
Collins, Graham P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonuomo, ValentinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sili, UluhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seval, Guldane CengizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machado, MarinaUNSPECIFIEDorcid.org/0000-0002-8370-2248UNSPECIFIED
Cordoba, RaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, OlaUNSPECIFIEDorcid.org/0000-0002-7167-7882UNSPECIFIED
Abu-Zeinah, GhaithUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamure, SylvainUNSPECIFIEDorcid.org/0000-0001-5980-305XUNSPECIFIED
Kulasekararaj, AustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cattaneo, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Doesum, JaapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piukovics, KlaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Omrani, Ali S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Magliano, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ledoux, Marie-PierreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Ramon, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabirta, AlbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verga, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Garcia, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Da Silva, Maria GomesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stojanoski, ZlateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meers, StefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lahmer, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin-Perez, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davila-Vals, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Van Praet, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samarkos, MichailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilgin, Yavuz M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Karlsson, Linda KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Batinic, JosipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordlander, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonlein, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mladenovic, MilosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanakova, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zambrotta, Giovanni Paolo MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Jonge, NickUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adzic-Vukicevic, TatjanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nunes-Rodrigues, RaquelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prezioso, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navratil, MilanUNSPECIFIEDorcid.org/0000-0002-2067-1253UNSPECIFIED
Marchetti, MoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuccaro, AnnarosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calbacho, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Giordano, AntonioUNSPECIFIEDorcid.org/0000-0001-7143-6758UNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hernandez-Rivas, Jose-AngelUNSPECIFIEDorcid.org/0000-0003-4550-757XUNSPECIFIED
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699274
DOI: 10.3389/fonc.2022.992137
Journal or Publication Title: Front. Oncol.
Volume: 12
Date: 2022
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2234-943X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CHRONIC LYMPHOCYTIC-LEUKEMIA; RNA COVID-19 VACCINE; RITUXIMAB; IBRUTINIB; EFFICACY; CHLORAMBUCIL; OBINUTUZUMAB; IDELALISIB; CHALLENGESMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69927

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