Verploegen, Maartje F. A., Vargas-Poussou, Rosa, Walsh, Stephen B., Alpay, Harika, Amouzegar, Atefeh, Ariceta, Gema, Atmis, Bahriye, Bacchetta, Justine, Barany, Peter, Baron, Stephanie ORCID: 0000-0002-0375-6968, Bayrakci, Umut Selda, Belge, Hendrica, Besouw, Martine, Blanchard, Anne, Bokenkamp, Arend, Boyer, Olivia, Burgmaier, Kathrin, Calo, Lorenzo A., Decramer, Stephane, Devuyst, Olivier ORCID: 0000-0003-3744-4767, van Dyck, Maria, Ferraro, Pietro Manuel, Fila, Marc, Francisco, Telma ORCID: 0000-0002-8232-6818, Ghiggeri, Gian Marco, Gondra, Leire, Guarino, Stefano, Hooman, Nakysa, Hoorn, Ewout J., Houillier, Pascal, Kamperis, Konstantinos ORCID: 0000-0003-0104-4884, Kari, Jameela A., Konrad, Martin, Levtchenko, Elena, Lucchetti, Laura, Lugani, Francesca, Marzuillo, Pierluigi ORCID: 0000-0003-4682-0170, Mohidin, Barian, Neuhaus, Thomas J., Osman, Abdaldafae, Papizh, Svetlana, Perello, Manel ORCID: 0000-0003-1859-5279, Rookmaaker, Maarten B., Conti, Valerie Said, Santos, Fernando, Sawaf, Ghalia, Serdaroglu, Erkin, Szczepanska, Maria ORCID: 0000-0002-6772-1983, Taroni, Francesca, Topaloglu, Rezan, Trepiccione, Francesco, Vidal, Enrico, Wan, Elizabeth R., Weber, Lutz, Yildirim, Zeynep Yuruk, Yuksel, Selcuk, Zlatanova, Galia ORCID: 0009-0000-0731-9151, Bockenhauer, Detlef, Emma, Francesco ORCID: 0000-0002-0383-3468 and Nijenhuis, Tom ORCID: 0000-0002-4375-7236 (2022). Parathyroid hormone and phosphate homeostasis in patients with Bartter and Gitelman syndrome: an international cross-sectional study. Nephrol. Dial. Transplant., 37 (12). S. 2474 - 2487. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2385

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Abstract

Background Small cohort studies have reported high parathyroid hormone (PTH) levels in patients with Bartter syndrome and lower serum phosphate levels have anecdotally been reported in patients with Gitelman syndrome. In this cross-sectional study, we assessed PTH and phosphate homeostasis in a large cohort of patients with salt-losing tubulopathies. Methods Clinical and laboratory data of 589 patients with Bartter and Gitelman syndrome were provided by members of the European Rare Kidney Diseases Reference Network (ERKNet) and the European Society for Paediatric Nephrology (ESPN). Results A total of 285 patients with Bartter syndrome and 304 patients with Gitelman syndrome were included for analysis. Patients with Bartter syndrome type I and II had the highest median PTH level (7.5 pmol/L) and 56% had hyperparathyroidism (PTH >7.0 pmol/L). Serum calcium was slightly lower in Bartter syndrome type I and II patients with hyperparathyroidism (2.42 versus 2.49 mmol/L; P = .038) compared to those with normal PTH levels and correlated inversely with PTH (r(s) -0.253; P = .009). Serum phosphate and urinary phosphate excretion did not correlate with PTH. Overall, 22% of patients had low serum phosphate levels (phosphate-standard deviation score < -2), with the highest prevalence in patients with Bartter syndrome type III (32%). Serum phosphate correlated with tubular maximum reabsorption of phosphate/glomerular filtration rate (TmP/GFR) (r(s) 0.699; P < .001), suggesting renal phosphate wasting. Conclusions Hyperparathyroidism is frequent in patients with Bartter syndrome type I and II. Low serum phosphate is observed in a significant number of patients with Bartter and Gitelman syndrome and appears associated with renal phosphate wasting.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Verploegen, Maartje F. A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vargas-Poussou, RosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walsh, Stephen B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alpay, HarikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amouzegar, AtefehUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ariceta, GemaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Atmis, BahriyeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bacchetta, JustineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Barany, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baron, StephanieUNSPECIFIEDorcid.org/0000-0002-0375-6968UNSPECIFIED
Bayrakci, Umut SeldaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Belge, HendricaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besouw, MartineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blanchard, AnneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bokenkamp, ArendUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boyer, OliviaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Burgmaier, KathrinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Calo, Lorenzo A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Decramer, StephaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devuyst, OlivierUNSPECIFIEDorcid.org/0000-0003-3744-4767UNSPECIFIED
van Dyck, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferraro, Pietro ManuelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fila, MarcUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Francisco, TelmaUNSPECIFIEDorcid.org/0000-0002-8232-6818UNSPECIFIED
Ghiggeri, Gian MarcoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gondra, LeireUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guarino, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hooman, NakysaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoorn, Ewout J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Houillier, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kamperis, KonstantinosUNSPECIFIEDorcid.org/0000-0003-0104-4884UNSPECIFIED
Kari, Jameela A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Konrad, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Levtchenko, ElenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lucchetti, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lugani, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marzuillo, PierluigiUNSPECIFIEDorcid.org/0000-0003-4682-0170UNSPECIFIED
Mohidin, BarianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neuhaus, Thomas J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Osman, AbdaldafaeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papizh, SvetlanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Perello, ManelUNSPECIFIEDorcid.org/0000-0003-1859-5279UNSPECIFIED
Rookmaaker, Maarten B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Conti, Valerie SaidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos, FernandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sawaf, GhaliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Serdaroglu, ErkinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szczepanska, MariaUNSPECIFIEDorcid.org/0000-0002-6772-1983UNSPECIFIED
Taroni, FrancescaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Topaloglu, RezanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trepiccione, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vidal, EnricoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wan, Elizabeth R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yildirim, Zeynep YurukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yuksel, SelcukUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zlatanova, GaliaUNSPECIFIEDorcid.org/0009-0000-0731-9151UNSPECIFIED
Bockenhauer, DetlefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emma, FrancescoUNSPECIFIEDorcid.org/0000-0002-0383-3468UNSPECIFIED
Nijenhuis, TomUNSPECIFIEDorcid.org/0000-0002-4375-7236UNSPECIFIED
URN: urn:nbn:de:hbz:38-699292
DOI: 10.1093/ndt/gfac029
Journal or Publication Title: Nephrol. Dial. Transplant.
Volume: 37
Number: 12
Page Range: S. 2474 - 2487
Date: 2022
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2385
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
HYPERPARATHYROIDISM; HYPERCALCIURIA; CALCIUM; GENEMultiple languages
Transplantation; Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69929

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