Cattaneo, Chiara, Salmanton-Garcia, Jon, Marchesi, Francesco ORCID: 0000-0001-6353-2272, El-Ashwah, Shaimaa ORCID: 0000-0003-2210-1534, Itri, Federico ORCID: 0000-0002-3532-5281, Weinbergerova, Barbora, Da Silva, Maria Gomes, Dargenio, Michelina, Davila-Valls, Julio, Martin-Perez, Sonia, Farina, Francesca ORCID: 0000-0002-5124-6970, Van Doesum, Jaap, Valkovic, Toni, Besson, Caroline, Poulsen, Christian Bjorn, Lopez-Garcia, Alberto, Zak, Pavel, Schonlein, Martin, Piukovics, Klara, Jaksic, Ozren, Cabirta, Alba, Ali, Natasha, Sili, Uluhan, Fracchiolla, Nicola, Dragonetti, Giulia, Adzic-Vukicevic, Tatjana, Marchetti, Monia, Machado, Marina ORCID: 0000-0002-8370-2248, Glenthoj, Andreas ORCID: 0000-0003-2082-0738, Finizio, Olimpia, Demirkan, Fatih, Blennow, Ola ORCID: 0000-0002-7167-7882, Tisi, Maria Chiara ORCID: 0000-0001-8231-6700, Omrani, Ali S., Navratil, Milan ORCID: 0000-0002-2067-1253, Racil, Zdenek, Novak, Jan, Magliano, Gabriele, Jimenez, Moraima, Garcia-Vidal, Carolina, Erben, Nurettin, Del Principe, Maria Ilaria, Buquicchio, Caterina, Bergantim, Rui, Batinic, Josip, Al-Khabori, Murtadha, Verga, Luisa, Szotkowski, Tomas, Samarkos, Michail, Ormazabal-Velez, Irati, Meers, Stef, Maertens, Johan, Pinczes, Laszlo Imre, Hoenigl, Martin, Drgona, L'ubos, Cuccaro, Annarosa, Bilgin, Yavuz M., Aujayeb, Avinash, Rahimli, Laman, Grafe, Stefanie, Sciume, Mariarita, Mladenovic, Milos, Colak, Gokce Melis, Sacchi, Maria Vittoria, Nordlander, Anna, Venemyr, Caroline Berg, Hanakova, Michaela, Garcia-Pouton, Nicole, Emarah, Ziad, Zambrotta, Giovanni Paolo Maria, Rodrigues, Raquel Nunes, Cordoba, Raul, Mendez, Gustavo-Adolfo, Biernat, Monika M., Cornely, Oliver A. and Pagano, Livio (2022). Simultaneous Onset of Haematological Malignancy and COVID: An Epicovideha Survey. Cancers, 14 (22). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary Patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 are an even greater challenge for hematologists. To better clarify their outcome, we describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Overall, 343 (76.2%) patients received treatment for HM, and an overall response rate was observed in 140 (40.8%) patients after the first line of treatment. Thirty-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004). Statistical analysis showed that, together with age, severe/critical COVID-19, >= 2 comorbidities, lack of HM treatment was an independent risk factors for mortality. These observations suggest the importance of HM treatment in these patients; therefore, it should be delivered as soon as possible for patients requiring immediate therapy. Background: The outcome of patients with simultaneous diagnosis of haematological malignancies (HM) and COVID-19 is unknown and there are no specific treatment guidelines. Methods: We describe the clinical features and outcome of a cohort of 450 patients with simultaneous diagnosis of HM and COVID-19 registered in the EPICOVIDEHA registry between March 2020 to February 2022. Results: Acute leukaemia and lymphoma were the most frequent HM (35.8% and 35.1%, respectively). Overall, 343 (76.2%) patients received treatment for HM, which was delayed for longer than one month since diagnosis in 57 (16.6%). An overall response rate was observed in 140 (40.8%) patients after the first line of treatment. After a median follow-up of 35 days, overall mortality was 177/450 (39.3%); 30-day mortality was significantly higher in patients not receiving HM treatment (42.1%) than in those receiving treatment (27.4%, p = 0.004), either before and/or after COVID-19, or compared to patients receiving HM treatment at least after COVID-19 (15.2%, p < 0.001). Age, severe/critical COVID-19, >= 2 comorbidities, and lack of HM treatment were independent risk factors for mortality, whereas a lymphocyte count >500/mcl at COVID-19 onset was protective. Conclusions: HM treatment should be delivered as soon as possible for patients with simultaneous diagnosis of COVID-19 and HM requiring immediate therapy.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Cattaneo, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmanton-Garcia, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchesi, FrancescoUNSPECIFIEDorcid.org/0000-0001-6353-2272UNSPECIFIED
El-Ashwah, ShaimaaUNSPECIFIEDorcid.org/0000-0003-2210-1534UNSPECIFIED
Itri, FedericoUNSPECIFIEDorcid.org/0000-0002-3532-5281UNSPECIFIED
Weinbergerova, BarboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Da Silva, Maria GomesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dargenio, MichelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davila-Valls, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin-Perez, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farina, FrancescaUNSPECIFIEDorcid.org/0000-0002-5124-6970UNSPECIFIED
Van Doesum, JaapUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valkovic, ToniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besson, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poulsen, Christian BjornUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Garcia, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zak, PavelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonlein, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piukovics, KlaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaksic, OzrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cabirta, AlbaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ali, NatashaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sili, UluhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fracchiolla, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dragonetti, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adzic-Vukicevic, TatjanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchetti, MoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machado, MarinaUNSPECIFIEDorcid.org/0000-0002-8370-2248UNSPECIFIED
Glenthoj, AndreasUNSPECIFIEDorcid.org/0000-0003-2082-0738UNSPECIFIED
Finizio, OlimpiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demirkan, FatihUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, OlaUNSPECIFIEDorcid.org/0000-0002-7167-7882UNSPECIFIED
Tisi, Maria ChiaraUNSPECIFIEDorcid.org/0000-0001-8231-6700UNSPECIFIED
Omrani, Ali S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Navratil, MilanUNSPECIFIEDorcid.org/0000-0002-2067-1253UNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Novak, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Magliano, GabrieleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimenez, MoraimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Vidal, CarolinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erben, NurettinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Del Principe, Maria IlariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buquicchio, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergantim, RuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Batinic, JosipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Al-Khabori, MurtadhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verga, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Szotkowski, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samarkos, MichailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ormazabal-Velez, IratiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meers, StefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maertens, JohanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinczes, Laszlo ImreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drgona, L'ubosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cuccaro, AnnarosaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bilgin, Yavuz M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aujayeb, AvinashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahimli, LamanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grafe, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sciume, MariaritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mladenovic, MilosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Colak, Gokce MelisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sacchi, Maria VittoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordlander, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venemyr, Caroline BergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanakova, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Garcia-Pouton, NicoleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Emarah, ZiadUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zambrotta, Giovanni Paolo MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodrigues, Raquel NunesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cordoba, RaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendez, Gustavo-AdolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biernat, Monika M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699348
DOI: 10.3390/cancers14225530
Journal or Publication Title: Cancers
Volume: 14
Number: 22
Date: 2022
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6694
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACUTE LYMPHOBLASTIC-LEUKEMIA; INFECTION; RECOMMENDATIONS; PANELMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69934

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