Sousa-Pinto, Bernardo ORCID: 0000-0002-1277-3401, Sa-Sousa, Ana ORCID: 0000-0002-9429-6863, Vieira, Rafael Jose, Amaral, Rita, Klimek, Ludger ORCID: 0000-0002-2455-0192, Czarlewski, Wienczyslawa, Anto, Josep M., Pfaar, Oliver, Bedbrook, Anna, Kvedariene, Violeta, Ventura, Maria Teresa, Ansotegui, Ignacio J., Bergmann, Karl-Christian, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Carreiro-Martins, Pedro, Casale, Tomas, Cecchi, Lorenzo ORCID: 0000-0002-0658-2449, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., De Feo, Giulia, Devillier, Philippe, Fokkens, Wytske J., Gaga, Mina, Gemicioglu, Bilun ORCID: 0000-0001-5953-4881, Haahtela, Tari, Ivancevich, Juan Carlos, Ispayeva, Zhanat, Jutel, Marek, Kuna, Piotr, Kaidashev, Igor ORCID: 0000-0002-4708-0859, Kraxner, Helga, Larenas-Linnemann, Desiree E., Laune, Daniel, Lipworth, Brian, Louis, Renaud, Makris, Michael, Monti, Riccardo ORCID: 0000-0002-1003-3629, Morais-Almeida, Mario, Mosges, Ralph, Mullol, Joaquim, Odemyr, Mikaela, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham-Thi, Nhan, Regateiro, Frederico S., Reitsma, Sietze, Rouadi, Philip W., Samolinski, Boleslaw, Sova, Milan, Todo-Bom, Ana, Taborda-Barata, Luis, Tomazic, Peter Valentin, Toppila-Salmi, Sanna ORCID: 0000-0003-0890-6686, Sastre, Joaquin, Tsiligianni, Ioanna, Valiulis, Arunas, Vandenplas, Olivier, Wallace, Dana, Waserman, Susan, Yorgancioglu, Arzu, Zidarn, Mihaela, Zuberbier, Torsten, Fonseca, Joao A. and Bousquet, Jean (2022). Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK-air(R) real-world data. Allergy, 77 (9). S. 2699 - 2712. HOBOKEN: WILEY. ISSN 1398-9995

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Abstract

Background Co-medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis-related search patterns in Google Trends. This study aims to assess AR co-medication and its regional patterns in Europe, using real-world data. Methods We analysed 2015-2020 MASK-air(R) European data. We compared days under no medication, monotherapy and co-medication using the visual analogue scale (VAS) levels for overall allergic symptoms ('VAS Global Symptoms') and impact of AR on work. We assessed the monthly use of different medication schemes, performing separate analyses by region (defined geographically or by Google Trends patterns). We estimated the average number of different drugs reported per patient within 1 year. Results We analysed 222,024 days (13,122 users), including 63,887 days (28.8%) under monotherapy and 38,315 (17.3%) under co-medication. The median 'VAS Global Symptoms' was 7 for no medication days, 14 for monotherapy and 21 for co-medication (p < .001). Medication use peaked during the spring, with similar patterns across different European regions (defined geographically or by Google Trends). Oral H-1-antihistamines were the most common medication in single and co-medication. Each patient reported using an annual average of 2.7 drugs, with 80% reporting two or more. Conclusions Allergic rhinitis medication patterns are similar across European regions. One third of treatment days involved co-medication. These findings suggest that patients treat themselves according to their symptoms (irrespective of how they understand AR) and that co-medication use is driven by symptom severity.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sousa-Pinto, BernardoUNSPECIFIEDorcid.org/0000-0002-1277-3401UNSPECIFIED
Sa-Sousa, AnaUNSPECIFIEDorcid.org/0000-0002-9429-6863UNSPECIFIED
Vieira, Rafael JoseUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Amaral, RitaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimek, LudgerUNSPECIFIEDorcid.org/0000-0002-2455-0192UNSPECIFIED
Czarlewski, WienczyslawaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anto, Josep M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pfaar, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bedbrook, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kvedariene, VioletaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ventura, Maria TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ansotegui, Ignacio J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bergmann, Karl-ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brussino, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canonica, G. WalterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cardona, VictoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carreiro-Martins, PedroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Casale, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cecchi, LorenzoUNSPECIFIEDorcid.org/0000-0002-0658-2449UNSPECIFIED
Chivato, TomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chu, Derek K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cingi, CemalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Costa, Elisio M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz, Alvaro A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Feo, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Devillier, PhilippeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fokkens, Wytske J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gaga, MinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gemicioglu, BilunUNSPECIFIEDorcid.org/0000-0001-5953-4881UNSPECIFIED
Haahtela, TariUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivancevich, Juan CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ispayeva, ZhanatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jutel, MarekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuna, PiotrUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaidashev, IgorUNSPECIFIEDorcid.org/0000-0002-4708-0859UNSPECIFIED
Kraxner, HelgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Larenas-Linnemann, Desiree E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laune, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipworth, BrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Louis, RenaudUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Makris, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monti, RiccardoUNSPECIFIEDorcid.org/0000-0002-1003-3629UNSPECIFIED
Morais-Almeida, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosges, RalphUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullol, JoaquimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Odemyr, MikaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Okamoto, YoshitakaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Papadopoulos, Nikolaos G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patella, VincenzoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pham-Thi, NhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Regateiro, Frederico S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reitsma, SietzeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rouadi, Philip W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samolinski, BoleslawUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sova, MilanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Todo-Bom, AnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taborda-Barata, LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tomazic, Peter ValentinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Toppila-Salmi, SannaUNSPECIFIEDorcid.org/0000-0003-0890-6686UNSPECIFIED
Sastre, JoaquinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tsiligianni, IoannaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valiulis, ArunasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vandenplas, OlivierUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallace, DanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waserman, SusanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yorgancioglu, ArzuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zidarn, MihaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuberbier, TorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fonseca, Joao A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bousquet, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699352
DOI: 10.1111/all.15275
Journal or Publication Title: Allergy
Volume: 77
Number: 9
Page Range: S. 2699 - 2712
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 1398-9995
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
Allergy; ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69935

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