de Erausquin, Gabriel A. ORCID: 0000-0001-6423-4461, Snyder, Heather, Brugha, Traolach S., Seshadri, Sudha, Carrillo, Maria, Sagar, Rajesh, Huang, Yueqin, Newton, Charles, Tartaglia, Carmela ORCID: 0000-0002-5944-8497, Teunissen, Charlotte, Hakanson, Krister, Akinyemi, Rufus, Prasad, Kameshwar, D'Avossa, Giovanni, Gonzalez-Aleman, Gabriela, Hosseini, Akram, Vavougios, George D., Sachdev, Perminder, Bankart, John, Mors, Niels Peter Ole, Lipton, Richard, Katz, Mindy, Fox, Peter T., Katshu, Mohammad Zia, Iyengar, M. Sriram, Weinstein, Galit, Sohrabi, Hamid R., Jenkins, Rachel, Stein, Dan J., Hugon, Jacques, Mavreas, Venetsanos, Blangero, John, Cruchaga, Carlos, Krishna, Murali, Wadoo, Ovais, Becerra, Rodrigo ORCID: 0000-0001-8286-7254, Zwir, Igor, Longstreth, William T., Kroenenberg, Golo, Edison, Paul, Mukaetova-Ladinska, Elizabeta, Staufenberg, Ekkehart, Figueredo-Aguiar, Mariana, Yecora, Agustin, Vaca, Fabiana, Zamponi, Hernan P., Lo Re, Vincenzina, Majid, Abdul, Sundarakumar, Jonas ORCID: 0000-0002-0877-7936, Gonzalez, Hector M., Geerlings, Mirjam, I, Skoog, Ingmar, Salmoiraghi, Alberto, Boneschi, Filippo Martinelli, Patel, Vibuthi N., Santos, Juan M., Rivera Arroyo, Guillermo, Caballero Moreno, Antonio, Felix, Pascal, Gallo, Carla, Arai, Hidenori, Yamada, Masahito, Iwatsubo, Takeshi, Sharma, Malveeka, Chakraborty, Nandini, Ferreccio, Catterina, Akena, Dickens, Brayne, Carol, Maestre, Gladys, Blangero, Sarah Williams, Brusco, Luis, I, Siddarth, Prabha, Hughes, Timothy M., Zuniga, Alfredo Ramirez, Kambeitz, Joseph, Laza, Agustin Ruiz, Allen, Norrina, Panos, Stella, Merrill, David, Ibanez, Agustin ORCID: 0000-0001-6758-5101, Tsuang, Debby, Valishvili, Nino, Shrestha, Srishti, Wang, Sophia, Padma, Vasantha, Anstey, Kaarin J., Ravindrdanath, Vijayalakshmi, Blennow, Kaj, Mullins, Paul, Pria, Anand, Mosley, Thomas H., Gowland, Penny ORCID: 0000-0002-4900-4817, Girard, Timothy D., Bowtell, Richard and Vahidy, Farhaan S. (2022). Chronic neuropsychiatric sequelae of SARS-CoV-2: Protocol and methods from the Alzheimer's Association Global Consortium. Alzheimers Dement.-Transl. Res. Clin. Interv., 8 (1). HOBOKEN: WILEY. ISSN 2352-8737

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Abstract

Introduction Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity of the original pulmonary illness. It behooves the scientific and medical community to attempt to understand the molecular and/or systemic factors linking COVID-19 to neurologic illness, both short and long term. Methods This article describes what is known so far in terms of links among COVID-19, the brain, neurological symptoms, and Alzheimer's disease (AD) and related dementias. We focus on risk factors and possible molecular, inflammatory, and viral mechanisms underlying neurological injury. We also provide a comprehensive description of the Alzheimer's Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) harmonized methodology to address these questions using a worldwide network of researchers and institutions. Results Successful harmonization of designs and methods was achieved through a consensus process initially fragmented by specific interest groups (epidemiology, clinical assessments, cognitive evaluation, biomarkers, and neuroimaging). Conclusions from subcommittees were presented to the whole group and discussed extensively. Presently data collection is ongoing at 19 sites in 12 countries representing Asia, Africa, the Americas, and Europe. Discussion The Alzheimer's Association Global Consortium harmonized methodology is proposed as a model to study long-term neurocognitive sequelae of SARS-CoV-2 infection. Key Points The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD) The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). The longitudinal methodologies espoused by the consortium are intended to provide data to answer this question as clearly as possible controlling for possible confounders. Our specific hypothesis is that SARS-CoV-2 triggers ADRD-like pathology following the extended olfactory cortical network (EOCN) in older individuals with specific genetic susceptibility. The proposed harmonization strategies and flexible study designs offer the possibility to include large samples of under-represented racial and ethnic groups, creating a rich set of harmonized cohorts for future studies of the pathophysiology, determinants, long-term consequences, and trends in cognitive aging, ADRD, and vascular disease. We provide a framework for current and future studies to be carried out within the Consortium. and offers a green paper to the research community with a very broad, global base of support, on tools suitable for low- and middle-income countries aimed to compare and combine future longitudinal data on the topic. The Consortium proposes a combination of design and statistical methods as a means of approaching causal inference of the COVID-19 neuropsychiatric sequelae. We expect that deep phenotyping of neuropsychiatric sequelae may provide a series of candidate syndromes with phenomenological and biological characterization that can be further explored. By generating high-quality harmonized data across sites we aim to capture both descriptive and, where possible, causal associations.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
de Erausquin, Gabriel A.UNSPECIFIEDorcid.org/0000-0001-6423-4461UNSPECIFIED
Snyder, HeatherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brugha, Traolach S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seshadri, SudhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Carrillo, MariaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sagar, RajeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Huang, YueqinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Newton, CharlesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tartaglia, CarmelaUNSPECIFIEDorcid.org/0000-0002-5944-8497UNSPECIFIED
Teunissen, CharlotteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hakanson, KristerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akinyemi, RufusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prasad, KameshwarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
D'Avossa, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gonzalez-Aleman, GabrielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hosseini, AkramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vavougios, George D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachdev, PerminderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bankart, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mors, Niels Peter OleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lipton, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katz, MindyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fox, Peter T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katshu, Mohammad ZiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iyengar, M. SriramUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinstein, GalitUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sohrabi, Hamid R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jenkins, RachelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stein, Dan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hugon, JacquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mavreas, VenetsanosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blangero, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruchaga, CarlosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krishna, MuraliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wadoo, OvaisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Becerra, RodrigoUNSPECIFIEDorcid.org/0000-0001-8286-7254UNSPECIFIED
Zwir, IgorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Longstreth, William T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kroenenberg, GoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Edison, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mukaetova-Ladinska, ElizabetaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Staufenberg, EkkehartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Figueredo-Aguiar, MarianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yecora, AgustinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vaca, FabianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zamponi, Hernan P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lo Re, VincenzinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Majid, AbdulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sundarakumar, JonasUNSPECIFIEDorcid.org/0000-0002-0877-7936UNSPECIFIED
Gonzalez, Hector M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Geerlings, Mirjam, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Skoog, IngmarUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmoiraghi, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boneschi, Filippo MartinelliUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Patel, Vibuthi N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santos, Juan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rivera Arroyo, GuillermoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caballero Moreno, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Felix, PascalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gallo, CarlaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Arai, HidenoriUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yamada, MasahitoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Iwatsubo, TakeshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sharma, MalveekaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chakraborty, NandiniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ferreccio, CatterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Akena, DickensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brayne, CarolUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maestre, GladysUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blangero, Sarah WilliamsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brusco, Luis, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Siddarth, PrabhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hughes, Timothy M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuniga, Alfredo RamirezUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kambeitz, JosephUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Laza, Agustin RuizUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Allen, NorrinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Panos, StellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Merrill, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ibanez, AgustinUNSPECIFIEDorcid.org/0000-0001-6758-5101UNSPECIFIED
Tsuang, DebbyUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valishvili, NinoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shrestha, SrishtiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wang, SophiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Padma, VasanthaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Anstey, Kaarin J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ravindrdanath, VijayalakshmiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, KajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mullins, PaulUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pria, AnandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosley, Thomas H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gowland, PennyUNSPECIFIEDorcid.org/0000-0002-4900-4817UNSPECIFIED
Girard, Timothy D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bowtell, RichardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vahidy, Farhaan S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699407
DOI: 10.1002/trc2.12348
Journal or Publication Title: Alzheimers Dement.-Transl. Res. Clin. Interv.
Volume: 8
Number: 1
Date: 2022
Publisher: WILEY
Place of Publication: HOBOKEN
ISSN: 2352-8737
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COGNITIVE IMPAIRMENT; COVID-19; MECHANISMS; MEMORY; RISK; HOSPITALIZATION; INFECTIONS; PREVENTION; CULTURES; ABILITYMultiple languages
Clinical Neurology; NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69940

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