Pagano, Livio, Salmanton-Garcia, Jon, Marchesi, Francesco ORCID: 0000-0001-6353-2272, Blennow, Ola ORCID: 0000-0002-7167-7882, da Silva, Maria Gomes, Glenthoj, Andreas ORCID: 0000-0003-2082-0738, van Doesum, Jaap ORCID: 0000-0003-0214-3219, Bilgin, Yavuz M., Lopez-Garcia, Alberto ORCID: 0000-0002-5354-5261, Itri, Federico ORCID: 0000-0002-3532-5281, Rodrigues, Raquel Nunes, Weinbergerova, Barbora, Farina, Francesca ORCID: 0000-0002-5124-6970, Dragonetti, Giulia, Venemyr, Caroline Berg, van Praet, Jens, Jaksic, Ozren, Valkovic, Toni, Falces-Romero, Iker, Martin-Perez, Sonia, Jimenez, Moraima, Davila-Valls, Julio, Schonlein, Martin, Ammatuna, Emanuele, Meers, Stef, Delia, Mario, Stojanoski, Zlate, Nordlander, Anna, Lahmer, Tobias, Pinczes, Laszlo Imre, Buquicchio, Caterina, Piukovics, Klara, Ormazabal-Velez, Irati, Fracchiolla, Nicola, Samarkos, Michail, Mendez, Gustavo-Adolfo, Hernandez-Rivas, Jose-Angel ORCID: 0000-0003-4550-757X, Espigado, Ildefonso, Cernan, Martin, Petzer, Verena, Lamure, Sylvain ORCID: 0000-0001-5980-305X, di Blasi, Roberta, de Almedia, Joyce Marques, Dargenio, Michelina, Biernat, Monika M., Sciume, Mariarita, de Ramon, Cristina, de Jonge, Nick ORCID: 0000-0002-9901-0887, Batinic, Josip, Aujayeb, Avinash, Marchetti, Monia, Fouquet, Guillemette, Fernandez, Noemi, Zambrotta, Giovanni, Sacchi, Maria Vittoria, Guidetti, Anna, Demirkan, Fatih, Prezioso, Lucia, Racil, Zdenek, Nucci, Marcio, Mladenovic, Milos, Lievin, Raphael, Hanakova, Michaela, Grafe, Stefanie, Sili, Uluhan, Machado, Marina ORCID: 0000-0002-8370-2248, Cattaneo, Chiara, Adzic-Vukicevic, Tatjana, Verga, Luisa, Labrador, Jorge, Rahimli, Laman, Bonanni, Matteo, Passamonti, Francesco, Pagliuca, Antonio, Corradini, Paolo, Hoenigl, Martin, Koehler, Philipp, Busca, Alessandro and Cornely, Oliver A. (2022). Breakthrough COVID-19 in vaccinated patients with hematologic malignancies: results from the EPICOVIDEHA survey. Blood, 140 (26). S. 2773 - 2788. WASHINGTON: AMER SOC HEMATOLOGY. ISSN 1528-0020

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Abstract

Limited data are available on breakthrough COVID-19 in patients with hematologic malignancy (HM) after anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) vaccination. Adult patients with HM, >= 1 dose of anti-SARS-CoV-2 vaccine, and breakthrough COVID-19 between January 2021 and March 2022 were analyzed. A total of 1548 cases were included, mainly lymphoid malignancies (1181 cases, 76%). After viral sequencing in 753 cases (49%), the Omicron variant was prevalent (517, 68.7%). Most of the patients received <= 2 vaccine doses before COVID-19 (1419, 91%), mostly mRNAbased (1377, 89%). Overall, 906 patients (59%) received COVID-19-specific treatment. After 30-day follow-up from COVID-19 diagnosis, 143 patients (9%) died. The mortality rate in patients with the Omicron variant was 7.9%, comparable to other variants, with a significantly lower 30-day mortality rate than in the prevaccine era (31%). In the univariable analysis, older age (P <.001), active HM (P <.001), and severe and critical COVID-19 (P =.007 and P <.001, respectively) were associated with mortality. Conversely, patients receiving monoclonal antibodies, even for severe or critical COVID-19, had a lower mortality rate (P <.001). In the multivariable model, older age, active disease, critical COVID-19, and 2-3 comorbidities were correlated with a higher mortality, whereas monoclonal antibody administration, alone (P <.001) or combined with antivirals (P =.009), was protective. Although mortality is significantly lower than in the prevaccination era, breakthrough COVID-19 in HM is still associated with considerable mortality. Death rate was lower in patients who received monoclonal antibodies, alone or in combination with antivirals.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Pagano, LivioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Salmanton-Garcia, JonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchesi, FrancescoUNSPECIFIEDorcid.org/0000-0001-6353-2272UNSPECIFIED
Blennow, OlaUNSPECIFIEDorcid.org/0000-0002-7167-7882UNSPECIFIED
da Silva, Maria GomesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Glenthoj, AndreasUNSPECIFIEDorcid.org/0000-0003-2082-0738UNSPECIFIED
van Doesum, JaapUNSPECIFIEDorcid.org/0000-0003-0214-3219UNSPECIFIED
Bilgin, Yavuz M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lopez-Garcia, AlbertoUNSPECIFIEDorcid.org/0000-0002-5354-5261UNSPECIFIED
Itri, FedericoUNSPECIFIEDorcid.org/0000-0002-3532-5281UNSPECIFIED
Rodrigues, Raquel NunesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinbergerova, BarboraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Farina, FrancescaUNSPECIFIEDorcid.org/0000-0002-5124-6970UNSPECIFIED
Dragonetti, GiuliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Venemyr, Caroline BergUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Praet, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jaksic, OzrenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Valkovic, ToniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falces-Romero, IkerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Martin-Perez, SoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jimenez, MoraimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davila-Valls, JulioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schonlein, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ammatuna, EmanueleUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meers, StefUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Delia, MarioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stojanoski, ZlateUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordlander, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lahmer, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pinczes, Laszlo ImreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buquicchio, CaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piukovics, KlaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ormazabal-Velez, IratiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fracchiolla, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Samarkos, MichailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mendez, Gustavo-AdolfoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hernandez-Rivas, Jose-AngelUNSPECIFIEDorcid.org/0000-0003-4550-757XUNSPECIFIED
Espigado, IldefonsoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cernan, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Petzer, VerenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lamure, SylvainUNSPECIFIEDorcid.org/0000-0001-5980-305XUNSPECIFIED
di Blasi, RobertaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Almedia, Joyce MarquesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dargenio, MichelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biernat, Monika M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sciume, MariaritaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Ramon, CristinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Jonge, NickUNSPECIFIEDorcid.org/0000-0002-9901-0887UNSPECIFIED
Batinic, JosipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aujayeb, AvinashUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marchetti, MoniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fouquet, GuillemetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fernandez, NoemiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zambrotta, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sacchi, Maria VittoriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Guidetti, AnnaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Demirkan, FatihUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prezioso, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Racil, ZdenekUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nucci, MarcioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mladenovic, MilosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lievin, RaphaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hanakova, MichaelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grafe, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sili, UluhanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Machado, MarinaUNSPECIFIEDorcid.org/0000-0002-8370-2248UNSPECIFIED
Cattaneo, ChiaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Adzic-Vukicevic, TatjanaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verga, LuisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Labrador, JorgeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rahimli, LamanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bonanni, MatteoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Passamonti, FrancescoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pagliuca, AntonioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corradini, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoenigl, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koehler, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Busca, AlessandroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cornely, Oliver A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-699437
DOI: 10.1182/blood.2022017257
Journal or Publication Title: Blood
Volume: 140
Number: 26
Page Range: S. 2773 - 2788
Date: 2022
Publisher: AMER SOC HEMATOLOGY
Place of Publication: WASHINGTON
ISSN: 1528-0020
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SARS-COV-2; INFECTIONSMultiple languages
HematologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69943

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