Lahti, Jari ORCID: 0000-0002-4310-5297, Tuominen, Samuli ORCID: 0000-0002-1879-0739, Yang, Qiong, Pergola, Giulio ORCID: 0000-0002-9193-1841, Ahmad, Shahzad ORCID: 0000-0002-8658-3790, Amin, Najaf ORCID: 0000-0002-8944-1771, Armstrong, Nicola J., Beiser, Alexa, Bey, Katharina, Bis, Joshua C., Boerwinkle, Eric, Bressler, Jan, Campbell, Archie, Campbell, Harry, Chen, Qiang, Corley, Janie, Cox, Simon R. ORCID: 0000-0003-4036-3642, Davies, Gail, De Jager, Philip L., Derks, Eske M., Faul, Jessica D., Fitzpatrick, Annette L., Fohner, Alison E., Ford, Ian, Fornage, Myriam, Gerring, Zachary ORCID: 0000-0002-2445-1266, Grabe, Hans J., Grodstein, Francine, Gudnason, Vilmundur ORCID: 0000-0001-5696-0084, Simonsick, Eleanor, Holliday, Elizabeth G., Joshi, Peter K., Kajantie, Eero, Kaprio, Jaakko ORCID: 0000-0002-3716-2455, Karell, Pauliina, Kleineidam, Luca, Knol, Maria J., Kochan, Nicole A., Kwok, John B., Leber, Markus, Lam, Max, Lee, Teresa, Li, Shuo ORCID: 0000-0003-2331-2448, Loukola, Anu, Luck, Tobias ORCID: 0000-0001-7551-4397, Marioni, Riccardo E., Mather, Karen A., Medland, Sarah, Mirza, Saira S., Nalls, Mike A., Nho, Kwangsik, O'Donnell, Adrienne, Oldmeadow, Christopher, Painter, Jodie, Pattie, Alison, Reppermund, Simone, Risacher, Shannon L., Rose, Richard J., Sadashivaiah, Vijay, Scholz, Markus, Satizabal, Claudia L., Schofield, Peter W., Schraut, Katharina E., Scott, Rodney J., Simino, Jeannette, Smith, Albert V., Smith, Jennifer A., Stott, David J., Surakka, Ida, Teumer, Alexander ORCID: 0000-0002-8309-094X, Thalamuthu, Anbupalam ORCID: 0000-0002-7114-1260, Trompet, Stella, Turner, Stephen T., van der Lee, Sven J., Villringer, Arno, Voelker, Uwe, Wilson, Robert S., Wittfeld, Katharina, Vuoksimaa, Eero ORCID: 0000-0002-6534-3667, Xia, Rui, Yaffe, Kristine, Yu, Lei, Zare, Habil ORCID: 0000-0001-5902-6238, Zhao, Wei, Ames, David, Attia, John, Bennett, David A., Brodaty, Henry, Chasman, Daniel I., Goldman, Aaron L., Hayward, Caroline, Ikram, M. Arfan, Jukema, J. Wouter, Kardia, Sharon L. R., Lencz, Todd ORCID: 0000-0001-8586-338X, Loeffler, Markus, Mattay, Venkata S., Palotie, Aarno ORCID: 0000-0002-2527-5874, Psaty, Bruce M., Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Ridker, Paul M., Riedel-Heller, Steffi G., Sachdev, Perminder S., Saykin, Andrew J., Scherer, Martin, Schofield, Peter R., Sidney, Stephen, Starr, John M., Trollor, Julian, Ulrich, William, Wagner, Michael, Weir, David R., Wilson, James F., Wright, Margaret J., Weinberger, Daniel R., Debette, Stephanie, Eriksson, Johan G., Mosley, Thomas H., Jr., Launer, Lenore J., van Duijn, Cornelia M., Deary, Ian J., Seshadri, Sudha and Raikkonen, Katri ORCID: 0000-0003-3124-3470 (2022). Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Mol. Psychiatr., 27 (11). S. 4419 - 4432. LONDON: SPRINGERNATURE. ISSN 1476-5578

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Abstract

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lahti, JariUNSPECIFIEDorcid.org/0000-0002-4310-5297UNSPECIFIED
Tuominen, SamuliUNSPECIFIEDorcid.org/0000-0002-1879-0739UNSPECIFIED
Yang, QiongUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pergola, GiulioUNSPECIFIEDorcid.org/0000-0002-9193-1841UNSPECIFIED
Ahmad, ShahzadUNSPECIFIEDorcid.org/0000-0002-8658-3790UNSPECIFIED
Amin, NajafUNSPECIFIEDorcid.org/0000-0002-8944-1771UNSPECIFIED
Armstrong, Nicola J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beiser, AlexaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bey, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bis, Joshua C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boerwinkle, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bressler, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, ArchieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Campbell, HarryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, QiangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Corley, JanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cox, Simon R.UNSPECIFIEDorcid.org/0000-0003-4036-3642UNSPECIFIED
Davies, GailUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
De Jager, Philip L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Derks, Eske M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Faul, Jessica D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fitzpatrick, Annette L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fohner, Alison E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ford, IanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fornage, MyriamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gerring, ZacharyUNSPECIFIEDorcid.org/0000-0002-2445-1266UNSPECIFIED
Grabe, Hans J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grodstein, FrancineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gudnason, VilmundurUNSPECIFIEDorcid.org/0000-0001-5696-0084UNSPECIFIED
Simonsick, EleanorUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Holliday, Elizabeth G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Joshi, Peter K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kajantie, EeroUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaprio, JaakkoUNSPECIFIEDorcid.org/0000-0002-3716-2455UNSPECIFIED
Karell, PauliinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kleineidam, LucaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Knol, Maria J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kochan, Nicole A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kwok, John B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leber, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lam, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, TeresaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Li, ShuoUNSPECIFIEDorcid.org/0000-0003-2331-2448UNSPECIFIED
Loukola, AnuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Luck, TobiasUNSPECIFIEDorcid.org/0000-0001-7551-4397UNSPECIFIED
Marioni, Riccardo E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mather, Karen A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Medland, SarahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mirza, Saira S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nalls, Mike A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nho, KwangsikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
O'Donnell, AdrienneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oldmeadow, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Painter, JodieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pattie, AlisonUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reppermund, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Risacher, Shannon L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rose, Richard J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sadashivaiah, VijayUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scholz, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Satizabal, Claudia L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schofield, Peter W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schraut, Katharina E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scott, Rodney J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Simino, JeannetteUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Albert V.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, Jennifer A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stott, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Surakka, IdaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teumer, AlexanderUNSPECIFIEDorcid.org/0000-0002-8309-094XUNSPECIFIED
Thalamuthu, AnbupalamUNSPECIFIEDorcid.org/0000-0002-7114-1260UNSPECIFIED
Trompet, StellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turner, Stephen T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Lee, Sven J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villringer, ArnoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Voelker, UweUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson, Robert S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wittfeld, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vuoksimaa, EeroUNSPECIFIEDorcid.org/0000-0002-6534-3667UNSPECIFIED
Xia, RuiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yaffe, KristineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Yu, LeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zare, HabilUNSPECIFIEDorcid.org/0000-0001-5902-6238UNSPECIFIED
Zhao, WeiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ames, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attia, JohnUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bennett, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brodaty, HenryUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chasman, Daniel I.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goldman, Aaron L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hayward, CarolineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ikram, M. ArfanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jukema, J. WouterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kardia, Sharon L. R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lencz, ToddUNSPECIFIEDorcid.org/0000-0001-8586-338XUNSPECIFIED
Loeffler, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mattay, Venkata S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Palotie, AarnoUNSPECIFIEDorcid.org/0000-0002-2527-5874UNSPECIFIED
Psaty, Bruce M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Ridker, Paul M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Riedel-Heller, Steffi G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sachdev, Perminder S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saykin, Andrew J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scherer, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schofield, Peter R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sidney, StephenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Starr, John M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Trollor, JulianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ulrich, WilliamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weir, David R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wilson, James F.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wright, Margaret J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weinberger, Daniel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Debette, StephanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eriksson, Johan G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mosley, Thomas H., Jr.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Launer, Lenore J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Duijn, Cornelia M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deary, Ian J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seshadri, SudhaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Raikkonen, KatriUNSPECIFIEDorcid.org/0000-0003-3124-3470UNSPECIFIED
URN: urn:nbn:de:hbz:38-699446
DOI: 10.1038/s41380-022-01710-8
Journal or Publication Title: Mol. Psychiatr.
Volume: 27
Number: 11
Page Range: S. 4419 - 4432
Date: 2022
Publisher: SPRINGERNATURE
Place of Publication: LONDON
ISSN: 1476-5578
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
COGNITIVE FUNCTIONS; EPISODIC MEMORY; QUALITY-CONTROL; WORKING-MEMORY; ASSOCIATION; CADHERIN; SCHIZOPHRENIA; EXPRESSION; DATABASE; NETWORKSMultiple languages
Biochemistry & Molecular Biology; Neurosciences; PsychiatryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/69944

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