Lahti, Jari ORCID: 0000-0002-4310-5297, Tuominen, Samuli ORCID: 0000-0002-1879-0739, Yang, Qiong, Pergola, Giulio ORCID: 0000-0002-9193-1841, Ahmad, Shahzad ORCID: 0000-0002-8658-3790, Amin, Najaf ORCID: 0000-0002-8944-1771, Armstrong, Nicola J., Beiser, Alexa, Bey, Katharina, Bis, Joshua C., Boerwinkle, Eric, Bressler, Jan, Campbell, Archie, Campbell, Harry, Chen, Qiang, Corley, Janie, Cox, Simon R. ORCID: 0000-0003-4036-3642, Davies, Gail, De Jager, Philip L., Derks, Eske M., Faul, Jessica D., Fitzpatrick, Annette L., Fohner, Alison E., Ford, Ian, Fornage, Myriam, Gerring, Zachary ORCID: 0000-0002-2445-1266, Grabe, Hans J., Grodstein, Francine, Gudnason, Vilmundur ORCID: 0000-0001-5696-0084, Simonsick, Eleanor, Holliday, Elizabeth G., Joshi, Peter K., Kajantie, Eero, Kaprio, Jaakko ORCID: 0000-0002-3716-2455, Karell, Pauliina, Kleineidam, Luca, Knol, Maria J., Kochan, Nicole A., Kwok, John B., Leber, Markus, Lam, Max, Lee, Teresa, Li, Shuo ORCID: 0000-0003-2331-2448, Loukola, Anu, Luck, Tobias ORCID: 0000-0001-7551-4397, Marioni, Riccardo E., Mather, Karen A., Medland, Sarah, Mirza, Saira S., Nalls, Mike A., Nho, Kwangsik, O'Donnell, Adrienne, Oldmeadow, Christopher, Painter, Jodie, Pattie, Alison, Reppermund, Simone, Risacher, Shannon L., Rose, Richard J., Sadashivaiah, Vijay, Scholz, Markus, Satizabal, Claudia L., Schofield, Peter W., Schraut, Katharina E., Scott, Rodney J., Simino, Jeannette, Smith, Albert V., Smith, Jennifer A., Stott, David J., Surakka, Ida, Teumer, Alexander ORCID: 0000-0002-8309-094X, Thalamuthu, Anbupalam ORCID: 0000-0002-7114-1260, Trompet, Stella, Turner, Stephen T., van der Lee, Sven J., Villringer, Arno, Voelker, Uwe, Wilson, Robert S., Wittfeld, Katharina, Vuoksimaa, Eero ORCID: 0000-0002-6534-3667, Xia, Rui, Yaffe, Kristine, Yu, Lei, Zare, Habil ORCID: 0000-0001-5902-6238, Zhao, Wei, Ames, David, Attia, John, Bennett, David A., Brodaty, Henry, Chasman, Daniel I., Goldman, Aaron L., Hayward, Caroline, Ikram, M. Arfan, Jukema, J. Wouter, Kardia, Sharon L. R., Lencz, Todd ORCID: 0000-0001-8586-338X, Loeffler, Markus, Mattay, Venkata S., Palotie, Aarno ORCID: 0000-0002-2527-5874, Psaty, Bruce M., Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Ridker, Paul M., Riedel-Heller, Steffi G., Sachdev, Perminder S., Saykin, Andrew J., Scherer, Martin, Schofield, Peter R., Sidney, Stephen, Starr, John M., Trollor, Julian, Ulrich, William, Wagner, Michael, Weir, David R., Wilson, James F., Wright, Margaret J., Weinberger, Daniel R., Debette, Stephanie, Eriksson, Johan G., Mosley, Thomas H., Jr., Launer, Lenore J., van Duijn, Cornelia M., Deary, Ian J., Seshadri, Sudha and Raikkonen, Katri ORCID: 0000-0003-3124-3470
(2022).
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Mol. Psychiatr., 27 (11).
S. 4419 - 4432.
LONDON:
SPRINGERNATURE.
ISSN 1476-5578
Full text not available from this repository.
Abstract
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Lahti, Jari | UNSPECIFIED | orcid.org/0000-0002-4310-5297 | UNSPECIFIED | Tuominen, Samuli | UNSPECIFIED | orcid.org/0000-0002-1879-0739 | UNSPECIFIED | Yang, Qiong | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pergola, Giulio | UNSPECIFIED | orcid.org/0000-0002-9193-1841 | UNSPECIFIED | Ahmad, Shahzad | UNSPECIFIED | orcid.org/0000-0002-8658-3790 | UNSPECIFIED | Amin, Najaf | UNSPECIFIED | orcid.org/0000-0002-8944-1771 | UNSPECIFIED | Armstrong, Nicola J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Beiser, Alexa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bey, Katharina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bis, Joshua C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Boerwinkle, Eric | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bressler, Jan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Campbell, Archie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Campbell, Harry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chen, Qiang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Corley, Janie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cox, Simon R. | UNSPECIFIED | orcid.org/0000-0003-4036-3642 | UNSPECIFIED | Davies, Gail | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | De Jager, Philip L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Derks, Eske M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Faul, Jessica D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fitzpatrick, Annette L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fohner, Alison E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ford, Ian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fornage, Myriam | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gerring, Zachary | UNSPECIFIED | orcid.org/0000-0002-2445-1266 | UNSPECIFIED | Grabe, Hans J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grodstein, Francine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gudnason, Vilmundur | UNSPECIFIED | orcid.org/0000-0001-5696-0084 | UNSPECIFIED | Simonsick, Eleanor | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Holliday, Elizabeth G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Joshi, Peter K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kajantie, Eero | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kaprio, Jaakko | UNSPECIFIED | orcid.org/0000-0002-3716-2455 | UNSPECIFIED | Karell, Pauliina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kleineidam, Luca | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Knol, Maria J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kochan, Nicole A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kwok, John B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Leber, Markus | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lam, Max | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lee, Teresa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Li, Shuo | UNSPECIFIED | orcid.org/0000-0003-2331-2448 | UNSPECIFIED | Loukola, Anu | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Luck, Tobias | UNSPECIFIED | orcid.org/0000-0001-7551-4397 | UNSPECIFIED | Marioni, Riccardo E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mather, Karen A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Medland, Sarah | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mirza, Saira S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nalls, Mike A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nho, Kwangsik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | O'Donnell, Adrienne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Oldmeadow, Christopher | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Painter, Jodie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Pattie, Alison | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Reppermund, Simone | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Risacher, Shannon L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rose, Richard J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sadashivaiah, Vijay | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scholz, Markus | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Satizabal, Claudia L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schofield, Peter W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schraut, Katharina E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scott, Rodney J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Simino, Jeannette | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Smith, Albert V. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Smith, Jennifer A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stott, David J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Surakka, Ida | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Teumer, Alexander | UNSPECIFIED | orcid.org/0000-0002-8309-094X | UNSPECIFIED | Thalamuthu, Anbupalam | UNSPECIFIED | orcid.org/0000-0002-7114-1260 | UNSPECIFIED | Trompet, Stella | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Turner, Stephen T. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van der Lee, Sven J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Villringer, Arno | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Voelker, Uwe | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wilson, Robert S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wittfeld, Katharina | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vuoksimaa, Eero | UNSPECIFIED | orcid.org/0000-0002-6534-3667 | UNSPECIFIED | Xia, Rui | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yaffe, Kristine | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Yu, Lei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zare, Habil | UNSPECIFIED | orcid.org/0000-0001-5902-6238 | UNSPECIFIED | Zhao, Wei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ames, David | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Attia, John | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Bennett, David A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Brodaty, Henry | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chasman, Daniel I. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Goldman, Aaron L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hayward, Caroline | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ikram, M. Arfan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jukema, J. Wouter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kardia, Sharon L. R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lencz, Todd | UNSPECIFIED | orcid.org/0000-0001-8586-338X | UNSPECIFIED | Loeffler, Markus | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mattay, Venkata S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Palotie, Aarno | UNSPECIFIED | orcid.org/0000-0002-2527-5874 | UNSPECIFIED | Psaty, Bruce M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ramirez, Alfredo | UNSPECIFIED | orcid.org/0000-0003-4991-763X | UNSPECIFIED | Ridker, Paul M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Riedel-Heller, Steffi G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sachdev, Perminder S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Saykin, Andrew J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scherer, Martin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schofield, Peter R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sidney, Stephen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Starr, John M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Trollor, Julian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ulrich, William | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wagner, Michael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Weir, David R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wilson, James F. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wright, Margaret J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Weinberger, Daniel R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Debette, Stephanie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Eriksson, Johan G. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mosley, Thomas H., Jr. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Launer, Lenore J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van Duijn, Cornelia M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Deary, Ian J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seshadri, Sudha | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Raikkonen, Katri | UNSPECIFIED | orcid.org/0000-0003-3124-3470 | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-699446 |
DOI: |
10.1038/s41380-022-01710-8 |
Journal or Publication Title: |
Mol. Psychiatr. |
Volume: |
27 |
Number: |
11 |
Page Range: |
S. 4419 - 4432 |
Date: |
2022 |
Publisher: |
SPRINGERNATURE |
Place of Publication: |
LONDON |
ISSN: |
1476-5578 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
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COGNITIVE FUNCTIONS; EPISODIC MEMORY; QUALITY-CONTROL; WORKING-MEMORY; ASSOCIATION; CADHERIN; SCHIZOPHRENIA; EXPRESSION; DATABASE; NETWORKS | Multiple languages | Biochemistry & Molecular Biology; Neurosciences; Psychiatry | Multiple languages |
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URI: |
http://kups.ub.uni-koeln.de/id/eprint/69944 |
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