Universität zu Köln

Taal, Adriaan J., Uguz, Ilke, Hillebrandt, Sabina ORCID: 0000-0002-2628-385X, Moon, Chang-Ki ORCID: 0000-0001-8286-5187, Andino-Pavlovsky, Victoria, Choi, Jaebin, Keum, Changmin ORCID: 0000-0003-4952-2566, Deisseroth, Karl, Gather, Malte C. ORCID: 0000-0002-4857-5562 and Shepard, Kenneth L. (2023). Optogenetic stimulation probes with single-neuron resolution based on organic LEDs monolithically integrated on CMOS. Nature Electronics, 6. pp. 669-679. Springer Nature. ISSN 2520-1131

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Abstract

The use of optogenetic stimulation to evoke neuronal activity in targeted neural populations—enabled by opsins with fast kinetics, high sensitivity and cell-type and subcellular specificity—is a powerful tool in neuroscience. However, to interface with the opsins, deep-brain light delivery systems are required that match the scale of the spatial and temporal control offered by the molecular actuators. Here we show that organic light-emitting diodes can be combined with complementary metal–oxide–semiconductor technology to create bright, actively multiplexed emissive elements. We create implantable shanks in which 1,024 individually addressable organic light-emitting diode pixels with a 24.5 μm pitch are integrated with active complementary metal–oxide–semiconductor drive and control circuitry. This integration is enabled by controlled electrode conditioning, monolithic deposition of the organic light-emitting diodes and optimized thin-film encapsulation. The resulting probes can be used to access brain regions as deep as 5 mm and selectively activate individual neurons with millisecond-level precision in mice.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Taal, Adriaan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Uguz, Ilke UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillebrandt, Sabina UNSPECIFIED orcid.org/0000-0002-2628-385X UNSPECIFIED Moon, Chang-Ki UNSPECIFIED orcid.org/0000-0001-8286-5187 UNSPECIFIED Andino-Pavlovsky, Victoria UNSPECIFIED UNSPECIFIED UNSPECIFIED Choi, Jaebin UNSPECIFIED UNSPECIFIED UNSPECIFIED Keum, Changmin UNSPECIFIED orcid.org/0000-0003-4952-2566 UNSPECIFIED Deisseroth, Karl UNSPECIFIED UNSPECIFIED UNSPECIFIED Gather, Malte C. UNSPECIFIED orcid.org/0000-0002-4857-5562 UNSPECIFIED Shepard, Kenneth L. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-715426
DOI:	10.1038/s41928-023-01013-y
Journal or Publication Title:	Nature Electronics
Volume:	6
Page Range:	pp. 669-679
Date:	2023
Publisher:	Springer Nature
ISSN:	2520-1131
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Physical Chemistry
Subjects:	Physics Technology (Applied sciences)
Funders:	Defense Advanced Research Projects Agency (DARPA) under contract N6600117C4012, National Institutes of Health under grant U01NS090596, Alexander von Humboldt Stiftung (Humboldt-Professorship to M.C.G.), National Nanotechnology Coordinated Infrastructure Program, NNCI-2025608, Marie-Skłodowska Curie Individual Fellowship (101029807)
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/71542