Universität zu Köln

Paul, Theresa ORCID: 0000-0003-0244-7503 (2023). Network mechanisms underlying motor control after ischemic stroke. PhD thesis, Universität zu Köln.

PDF Dissertation_Paul_Theresa_angenommen.pdf Download (32MB)

Abstract

Motor impairment is one of the most common symptoms after ischemic stroke. While many patients partially regain lost functions due to plastic changes to the structural and functional architecture of brain networks, recovery is often incomplete, making stroke a leading cause of long-term disability worldwide. Thus, a better mechanistic understanding of motor recovery seems crucial to inform future plasticity-enhancing treatment approaches. The studies summarized in the present thesis therefore aimed at furthering our mechanistic insights into motor network reorganization in acute and chronic stroke patients. In study 1, we focused on the role of different descending motor pathways on distinct aspects of motor control. Study 2 addressed the role of corticospinal output fibers descending from the primary motor cortex (M1) and various premotor areas. In study 3, we assessed cortico-cortical structural connectivity and its differential association with basal and complex motor functions. Finally, study 4 utilized fMRI-data from acute stroke patients to conduct the first direct comparison of resting-state functional and task-related effective connectivity. Taken together, our findings offer novel insights into mechanisms underlying motor control after stroke and hold important implications for therapeutic interventions.

Item Type:	Thesis (PhD thesis)
Creators:	Creators Email ORCID ORCID Put Code Paul, Theresa Theresa.Paul@uk-koeln.de orcid.org/0000-0003-0244-7503 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-718032
Date:	2023
Language:	English
Faculty:	Faculty of Human Sciences
Divisions:	Faculty of Human Sciences > Department Psychologie
Subjects:	Psychology Medical sciences Medicine
Uncontrolled Keywords:	Keywords Language stroke English motor recovery English rehabilitation English motor pathways English brain network connectivity English diffusion imaging English functional magnetic resonance imaging English
Date of oral exam:	16 August 2023
Referee:	Name Academic Title Peters, Jan Prof. Dr. Vossel, Simone Prof. Dr.
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/71803