Bergami, Matteo (2018). Critical periods regulating the circuit integration of adult-born hippocampal neurons. Cell and tissue research, 371 (1). pp. 23-32. Berlin ; Heidelberg: Springer. ISSN 0302-766X

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Abstract

The dentate gyrus (DG) in the adult brain maintains the capability to generate new granule neurons life-long. Neural stem cell-derived new-born neurons are emerging for playing key functions in the way information is processed in the DG and then conveyed to the CA3 hippocampal area, yet accumulating evidence indicates that both the maturation process and the connectivity pattern of new granule neurons are not prefigured, but can be modulated by the activity of local microcircuits and, on a network level, by experience. Although most of the so-far described activity- and experience-dependent changes appear to be restricted to critical periods during the development of new granule neurons, it is becoming increasingly clear that the surrounding circuits may play equally key roles in accommodating, and perhaps fostering, these changes. Here, we review some of the most recent insights into this almost unique form of plasticity in the adult brain by focussing on those critical periods marked by pronounced changes in structure and function of the new granule neurons, and discuss how the activity of putative synaptic partners may contribute to shape the circuit module in which new neurons become finally integrated.

Item Type: Journal Article
Creators:
CreatorsEmailORCID
Bergami, Matteomatteo.bergami@uk-koeln.deUNSPECIFIED
URN: urn:nbn:de:hbz:38-94737
DOI: 10.1007/s00441-017-2677-x
Journal or Publication Title: Cell and tissue research
Publisher: Springer
ISSN: 0302-766X
Volume: 371
Number: 1
Subjects: Life sciences
Faculty: Faculty of Mathematics and Natural Sciences
Divisions: Faculty of Mathematics and Natural Sciences > Exzellenzcluster Cellular Stress Responses in Aging-Associated Diseases (CECAD)
Language: English
Date: 2018
Related URLs:
Funders: European Research Council (ERC-StG-2015, grant number 67844)
Place of Publication: Berlin ; Heidelberg
Refereed: Yes
Page Range: pp. 23-32
URI: http://kups.ub.uni-koeln.de/id/eprint/9473

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