Universität zu Köln

2023

Ishorst, Nina, Henschel, Leonie, Thieme, Frederic, Drichel, Dmitriy, Sivalingam, Sugirthan, Mehrem, Sarah L., Fechtner, Ariane C., Fazaal, Julia, Welzenbach, Julia, Heimbach, Andre, Maj, Carlo, Borisov, Oleg, Hausen, Jonas, Raff, Ruth, Hoischen, Alexander ORCID: 0000-0002-8072-4476, Dixon, Michael, Rada-Iglesias, Alvaro, Bartusel, Michaela, Rojas-Martinez, Augusto, Aldhorae, Khalid, Braumann, Bert, Kruse, Teresa, Kirschneck, Christian, Spanier, Gerrit, Reutter, Heiko, Nowak, Stefanie, Goelz, Lina, Knapp, Michael, Buness, Andreas, Krawitz, Peter, Noethen, Markus M., Nothnagel, Michael, Becker, Tim, Ludwig, Kerstin U. and Mangold, Elisabeth (2023). Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores. Mol. Genet. Genom. Med., 11 (3). HOBOKEN: WILEY. ISSN 2324-9269

2022

Srinivasan, Sureshkumar Perumal, Nemade, Harshal ORCID: 0000-0002-2704-181X, Cherianidou, Anna, Peng, Luying, Cruz-Molina, Sara, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 and Sachinidis, Agapios (2022). Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells. Cell Death Discov., 8 (1). LONDON: SPRINGERNATURE. ISSN 2058-7716

Vicioso-Mantis, Marta, Fueyo, Raquel, Navarro, Claudia, Cruz-Molina, Sara, van Ijcken, Wilfred F. J., Rebollo, Elena, Rada-Iglesias, Alvaro and Martinez-Balbas, Marian A. (2022). JMJD3 intrinsically disordered region links the 3D-genome structure to TGF beta-dependent transcription activation. Nat. Commun., 13 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

2021

Bleckwehl, Tore, Crispatzu, Giuliano, Schaaf, Kaitlin, Respuela, Patricia, Bartusel, Michaela ORCID: 0000-0003-1008-1951, Benson, Laura, Clark, Stephen J., Dorighi, Kristel M., Barral, Antonio, Laugsch, Magdalena, van Ijcken, Wilfred F. J., Manzanares, Miguel ORCID: 0000-0003-4849-2836, Wysocka, Joanna, Reikf, Wolf and Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2021). Enhancer-associated H3K4 methylation safeguards in vitro germline competence. Nat. Commun., 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

Crispatzu, Giuliano, Rehimi, Rizwan, Pachano, Tomas, Bleckwehl, Tore, Cruz-Molina, Sara, Xiao, Cally ORCID: 0000-0001-7172-3175, Mahabir, Esther, Bazzi, Hisham ORCID: 0000-0001-8388-4005 and Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2021). The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo. Nat. Commun., 12 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723

Kargapolova, Yulia ORCID: 0000-0001-7541-5778, Rehimi, Rizwan, Kayserili, Huelya, Bruehl, Joanna, Sofiadis, Konstantinos, Zirkel, Anne, Palikyras, Spiros, Mizi, Athanasia, Li, Yun, Yigit, Goekhan, Hoischen, Alexander ORCID: 0000-0002-8072-4476, Frank, Stefan, Russ, Nicole, Trautwein, Jonathan, van Bon, Bregje, Gilissen, Christian ORCID: 0000-0003-1693-9699, Laugsch, Magdalena, Gusmao, Eduardo Gade, Josipovic, Natasa ORCID: 0000-0001-7683-0869, Altmueller, Janine, Nuernberg, Peter, Laengst, Gernot, Kaiser, Frank J., Watrin, Erwan, Brunner, Han, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341, Kurian, Leo ORCID: 0000-0001-7466-5169, Wollnik, Bernd ORCID: 0000-0003-2589-0364, Bouazoune, Karim and Papantonis, Argyris (2021). Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology. Nat. Commun., 12 (1). BERLIN: NATURE RESEARCH. ISSN 2041-1723

Koester, Janis ORCID: 0000-0002-5274-0591, Miroshnikova, Yekaterina A., Ghatak, Sushmita, Chacon-Martinez, Carlos Andres, Morgner, Jessica ORCID: 0000-0001-6374-8639, Li, Xinping ORCID: 0000-0002-7427-0017, Atanassov, Ilian ORCID: 0000-0001-8259-2545, Altmueller, Janine, Birk, David E., Koch, Manuel ORCID: 0000-0002-2962-7814, Bloch, Wilhelm, Bartusel, Michaela, Niessen, Carien M. ORCID: 0000-0002-4892-9391, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 and Wickstroem, Sara A. (2021). Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility. Nat. Cell Biol., 23 (7). S. 771 - 797. BERLIN: NATURE RESEARCH. ISSN 1476-4679

Pachano, Tomas, Sanchez-Gaya, Victor, Ealo, Thais, Mariner-Fauli, Maria, Bleckwehl, Tore, Asenjo, Helena G., Respuela, Patricia, Cruz-Molina, Sara, Munoz-San Martin, Maria, Haro, Endika, van IJcken, Wilfred F. J., Landeira, David ORCID: 0000-0002-3267-454X and Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2021). Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness. Nature Genet., 53 (7). S. 1036 - 1074. BERLIN: NATURE RESEARCH. ISSN 1546-1718

Thues, Cedric, Valadas, Jorge S., Deaulmerie, Liesbeth, Geens, Ann, Chouhan, Amit K., Duran-Romana, Ramon ORCID: 0000-0002-2020-8672, Schymkowitz, Joost, Rousseau, Frederic, Bartusel, Michaela, Rehimi, Rizwan, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341, Verstreken, Patrik ORCID: 0000-0002-5073-5393 and Van Esch, Hilde (2021). MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome. Sci Rep, 11 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

2020

Bastida, Maria Felix, Perez-Gomez, Rocio, Trofka, Anna, Zhu, Jianjian, Rada-Iglesias, Alvaro, Sheth, Rushikesh, Stadler, H. Scott, Mackem, Susan and Ros, Marian A. (2020). The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc. Natl. Acad. Sci. U. S. A., 117 (2). S. 1090 - 1097. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424

Boles, Nathan C., Fernandes, Marie, Swigut, Tomasz, Srinivasan, Rajini, Schiff, Lauren ORCID: 0000-0003-2438-2456, Rada-Iglesias, Alvaro, Wang, Qingjie, Saini, Janmeet S., Kiehl, Thomas, Stern, Jeffrey H., Wysocka, Joanna, Blenkinsop, Timothy A. and Temple, Sally (2020). Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide. Stem Cell Rep., 14 (4). S. 631 - 648. CAMBRIDGE: CELL PRESS. ISSN 2213-6711

Fatima, Azra, Irmak, Dilber, Noormohammadi, Alireza, Rinschen, Markus M., Das, Aniruddha ORCID: 0000-0002-7704-3573, Leidecker, Orsolya, Schindler, Christina, Sanchez-Gaya, Victor, Wagle, Prerana, Pokrzywa, Wojciech ORCID: 0000-0002-5110-4462, Hoppe, Thorsten ORCID: 0000-0002-4734-9352, Rada-Iglesias, Alvaro and Vilchez, David (2020). The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells. Commun. Biol., 3 (1). NEW YORK: NATURE PUBLISHING GROUP. ISSN 2399-3642

Sanchez-Gaya, Victor, Mariner-Fauli, Maria and Rada-Iglesias, Alvaro (2020). Rare or Overlooked? Structural Disruption of Regulatory Domains in Human Neurocristopathies. Front. Genet., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021

2019

Bleckwehl, Tore and Rada-Iglesias, Alvaro (2019). Transcriptional and epigenetic control of germline competence and specification. Curr. Opin. Cell Biol., 61. S. 1 - 9. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410

Frank, Stefan, Ahuja, Gaurav ORCID: 0000-0002-2837-9361, Bartsch, Deniz, Russ, Nicole, Yao, Wenjie, Kuo, Joseph Chao-Chung, Derks, Jens-Peter, Akhade, Vijay Suresh, Kargapolova, Yulia, Georgomanolis, Theodore, Messling, Jan-Erik ORCID: 0000-0003-3843-0041, Gramm, Marie, Brant, Lilija, Rehimi, Rizwan, Vargas, Natalia Emilse, Kuroczik, Alina, Yang, Tsun-Po, Sahito, Raja Ghazanfar Ali, Franzen, Julia, Hescheler, Juergen, Sachinidis, Agapios, Peifer, Martin, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341, Kanduri, Meena, Costa, Ivan G. ORCID: 0000-0003-2890-8697, Kanduri, Chandrasekhar, Papantonis, Argyris ORCID: 0000-0001-7551-1073 and Kurian, Leo ORCID: 0000-0001-7466-5169 (2019). yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs. Cell Stem Cell, 24 (2). S. 318 - 336. CAMBRIDGE: CELL PRESS. ISSN 1875-9777

Laugsch, Magdalena, Bartusel, Michaela, Rehimi, Rizwan, Alirzayeva, Hafiza, Karaolidou, Agathi, Crispatzu, Giuliano, Zentis, Peter, Nikolic, Milos ORCID: 0000-0003-0029-7601, Bleckwehl, Tore, Kolovos, Petros ORCID: 0000-0002-0787-6158, van Ijcken, Wilfred F. J., Saric, Tomo, Koehler, Katrin, Frommolt, Peter ORCID: 0000-0002-1966-8014, Lachlan, Katherine, Baptista, Julia and Rada-Iglesias, Alvaro (2019). Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs. Cell Stem Cell, 24 (5). S. 736 - 765. CAMBRIDGE: CELL PRESS. ISSN 1875-9777

Matheus, Friederike, Rusha, Ejona, Rehimi, Rizwan, Molitor, Lena, Pertek, Anna, Modic, Miha, Feederle, Regina, Flatley, Andrew, Kremmer, Elisabeth, Geerlof, Arie, Rishko, Valentyna, Rada-Iglesias, Alvaro and Drukker, Micha (2019). Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development. Stem Cell Rep., 12 (5). S. 861 - 869. CAMBRIDGE: CELL PRESS. ISSN 2213-6711

Pachano, Tomas, Crispatzu, Giuliano and Rada-Iglesias, Alvaro (2019). Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells. Brief. Funct. Genomics, 18 (6). S. 358 - 367. OXFORD: OXFORD UNIV PRESS. ISSN 2041-2657

Zanella, Matteo ORCID: 0000-0002-1614-4370, Vitriolo, Alessandro ORCID: 0000-0002-1462-8064, Andirko, Alejandro, Tiago Martins, Pedro, Sturm, Stefanie, O'Rourke, Thomas ORCID: 0000-0003-2231-8450, Laugsch, Magdalena, Malerba, Natascia ORCID: 0000-0003-0714-3314, Skaros, Adrianos, Trattaro, Sebastiano ORCID: 0000-0002-3142-6747, Germain, Pierre-Luc, Mihailovic, Marija ORCID: 0000-0001-7478-2509, Merla, Giuseppe, Rada-Iglesias, Alvaro, Boeckx, Cedric and Testa, Giuseppe (2019). Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication. Sci. Adv., 5 (12). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 2375-2548

2018

Fernandes, Marie, Schiff, Lauren, Swigut, Tomasz, Boles, Nathan, Srinivasan, Rajini, Rada-Iglesias, Alvaro, Wang, Qingjie, Saini, Janmeet, Kiehl, Tom, Stern, Jeffrey, Wysocka, Joanna, Temple, Sally and Blenkinsop, Timothy A. (2018). Nicotinamide protects against PVR by preventing RPE cells to undergo EMT. Invest. Ophthalmol. Vis. Sci., 59 (9). ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. ISSN 1552-5783

Fueyo, Raquel, Iacobucci, Simona, Pappa, Stella, Estaras, Conchi ORCID: 0000-0002-2600-5841, Lois, Sergio, Vicioso-Mantis, Marta, Navarro, Claudia, Cruz-Molina, Sara, Carlos Reyes, Jose, Rada-Iglesias, Alvaro, de la Cruz, Xavier and Martinez-Balbas, Marian A. (2018). Lineage specific transcription factors and epigenetic regulators mediate TGF beta-dependent enhancer activation. Nucleic Acids Res., 46 (7). S. 3351 - 3366. OXFORD: OXFORD UNIV PRESS. ISSN 1362-4962

Irmak, Dilber, Fatima, Azra, Gutierrez-Garcia, Ricardo, Rinschen, Markus M., Wagle, Prerana, Altmueller, Janine, Arrigoni, Laura, Hummel, Barbara ORCID: 0000-0001-6563-3675, Klein, Corinna, Frese, Christian K., Sawarkar, Ritwick, Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 and Vilchez, David ORCID: 0000-0002-0801-0743 (2018). Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations. Hum. Mol. Genet., 27 (23). S. 4117 - 4135. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2083

Rada-Iglesias, Alvaro (2018). Is H3K4me1 at enhancers correlative or causative? Nature Genet., 50 (1). S. 4 - 7. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718

Rada-Iglesias, Alvaro (2018). Pioneering of Enhancer Landscapes during Pluripotent State Transitions. Cell Stem Cell, 23 (2). S. 149 - 152. CAMBRIDGE: CELL PRESS. ISSN 1875-9777

Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341, Grosveld, Frank G. and Papantonis, Argyris ORCID: 0000-0001-7551-1073 (2018). Forces driving the three-dimensional folding of eukaryotic genomes. Mol. Syst. Biol., 14 (6). HOBOKEN: WILEY. ISSN 1744-4292

2017

Cruz-Molina, Sara, Respuela, Patricia ORCID: 0000-0002-9719-7860, Tebartz, Christina, Kolovos, Petros ORCID: 0000-0002-0787-6158, Nikolic, Milos ORCID: 0000-0003-0029-7601, Fueyo, Raquel, van Ijcken, Wilfred F. J., Grosveld, Frank, Frommolt, Peter ORCID: 0000-0002-1966-8014, Bazzi, Hisham ORCID: 0000-0001-8388-4005 and Rada-Iglesias, Alvaro (2017). PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation. Cell Stem Cell, 20 (5). S. 689 - 715. CAMBRIDGE: CELL PRESS. ISSN 1875-9777

Ludwig, Kerstin U., Boehmer, Anne C., Bowes, John, Nikolic, Milos ORCID: 0000-0003-0029-7601, Ishorst, Nina, Wyatt, Niki, Hammond, Nigel L., Goelz, Lina, Thieme, Frederic, Barth, Sandra, Schuenke, Hannah, Klamt, Johanna, Spielmann, Malte ORCID: 0000-0002-0583-4683, Aldhorae, Khalid ORCID: 0000-0002-5920-8004, Rojas-Martinez, Augusto, Noethen, Markus M., Rada-Iglesias, Alvaro, Dixon, Michael J., Knapp, Michael and Mangold, Elisabeth (2017). Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip 6 cleft palate and cleft palate only. Hum. Mol. Genet., 26 (4). S. 829 - 843. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2083

Nikolic, Milos ORCID: 0000-0003-0029-7601, Papantonis, Argyris ORCID: 0000-0001-7551-1073 and Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2017). GARLIC: a bioinformatic toolkit for aetiologically connecting diseases and cell type-specific regulatory maps. Hum. Mol. Genet., 26 (4). S. 742 - 753. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2083

Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2017). Ready, Set. . .Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation. Mol. Syst. Biol., 13 (10). HOBOKEN: WILEY. ISSN 1744-4292

Rehimi, Rizwan, Bartusel, Michaela, Solinas, Francesca, Altmueller, Janine and Rada-Iglesias, Alvaro (2017). Chromatin Immunoprecipitation (ChIP) Protocol for Low-abundance Embryonic Samples. J. Vis. Exp. (126). CAMBRIDGE: JOURNAL OF VISUALIZED EXPERIMENTS. ISSN 1940-087X

2016

Lu, Rong, Rada-Iglesias, Alvaro and Phillips-Cremins, Jennifer ORCID: 0000-0002-4702-0450 (2016). The Path to My Lab's First Paper: Rong Lu, Alvaro Rada-Iglesias, and Jennifer Phillips-Cremins. Cell Stem Cell, 19 (6). S. 683 - 686. CAMBRIDGE: CELL PRESS. ISSN 1875-9777

Rehimi, Rizwan, Nikolic, Milos ORCID: 0000-0003-0029-7601, Cruz-Molina, Sara, Tebartz, Christina, Frommolt, Peter ORCID: 0000-0002-1966-8014, Mahabir, Esther, Clement-Ziza, Mathieu ORCID: 0000-0003-2763-249X and Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2016). Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations. Cell Reports, 17 (11). S. 3062 - 3077. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Respuela, Patricia ORCID: 0000-0002-9719-7860, Nikolic, Milos ORCID: 0000-0003-0029-7601, Tan, Minjia ORCID: 0000-0002-6784-9653, Frommolt, Peter ORCID: 0000-0002-1966-8014, Zhao, Yingming, Wysocka, Joanna and Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2016). Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification. Cell Stem Cell, 18 (1). S. 118 - 134. CAMBRIDGE: CELL PRESS. ISSN 1875-9777

Respuela, Patricia and Rada-Iglesias, Alvaro (2016). Enhancer Remodeling During Early Mammalian Embryogenesis: Lessons for Somatic Reprogramming, Rejuvenation, and Aging. Curr. Stem. Cell Rep., 2 (3). S. 263 - 273. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2198-7866

2014

Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341 (2014). Genetic variation within transcriptional regulatory elements and its implications for human disease. Biol. Chem., 395 (12). S. 1453 - 1461. BERLIN: WALTER DE GRUYTER GMBH. ISSN 1437-4315