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2023
Ishorst, Nina, Henschel, Leonie, Thieme, Frederic, Drichel, Dmitriy, Sivalingam, Sugirthan, Mehrem, Sarah L., Fechtner, Ariane C., Fazaal, Julia, Welzenbach, Julia, Heimbach, Andre, Maj, Carlo, Borisov, Oleg, Hausen, Jonas, Raff, Ruth, Hoischen, Alexander ORCID: 0000-0002-8072-4476, Dixon, Michael, Rada-Iglesias, Alvaro, Bartusel, Michaela, Rojas-Martinez, Augusto, Aldhorae, Khalid, Braumann, Bert, Kruse, Teresa, Kirschneck, Christian, Spanier, Gerrit, Reutter, Heiko, Nowak, Stefanie, Goelz, Lina, Knapp, Michael, Buness, Andreas, Krawitz, Peter, Noethen, Markus M., Nothnagel, Michael, Becker, Tim, Ludwig, Kerstin U. and Mangold, Elisabeth
(2023).
Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores.
Mol. Genet. Genom. Med., 11 (3).
HOBOKEN:
WILEY.
ISSN 2324-9269
2022
Srinivasan, Sureshkumar Perumal, Nemade, Harshal ORCID: 0000-0002-2704-181X, Cherianidou, Anna, Peng, Luying, Cruz-Molina, Sara, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341 and Sachinidis, Agapios
(2022).
Epigenetic mechanisms of Strip2 in differentiation of pluripotent stem cells.
Cell Death Discov., 8 (1).
LONDON:
SPRINGERNATURE.
ISSN 2058-7716
Vicioso-Mantis, Marta, Fueyo, Raquel, Navarro, Claudia, Cruz-Molina, Sara, van Ijcken, Wilfred F. J., Rebollo, Elena, Rada-Iglesias, Alvaro and Martinez-Balbas, Marian A. (2022). JMJD3 intrinsically disordered region links the 3D-genome structure to TGF beta-dependent transcription activation. Nat. Commun., 13 (1). BERLIN: NATURE PORTFOLIO. ISSN 2041-1723
2021
Bleckwehl, Tore, Crispatzu, Giuliano, Schaaf, Kaitlin, Respuela, Patricia, Bartusel, Michaela ORCID: 0000-0003-1008-1951, Benson, Laura, Clark, Stephen J., Dorighi, Kristel M., Barral, Antonio, Laugsch, Magdalena, van Ijcken, Wilfred F. J., Manzanares, Miguel
ORCID: 0000-0003-4849-2836, Wysocka, Joanna, Reikf, Wolf and Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341
(2021).
Enhancer-associated H3K4 methylation safeguards in vitro germline competence.
Nat. Commun., 12 (1).
BERLIN:
NATURE PORTFOLIO.
ISSN 2041-1723
Crispatzu, Giuliano, Rehimi, Rizwan, Pachano, Tomas, Bleckwehl, Tore, Cruz-Molina, Sara, Xiao, Cally ORCID: 0000-0001-7172-3175, Mahabir, Esther, Bazzi, Hisham
ORCID: 0000-0001-8388-4005 and Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341
(2021).
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo.
Nat. Commun., 12 (1).
BERLIN:
NATURE PORTFOLIO.
ISSN 2041-1723
Kargapolova, Yulia ORCID: 0000-0001-7541-5778, Rehimi, Rizwan, Kayserili, Huelya, Bruehl, Joanna, Sofiadis, Konstantinos, Zirkel, Anne, Palikyras, Spiros, Mizi, Athanasia, Li, Yun, Yigit, Goekhan, Hoischen, Alexander
ORCID: 0000-0002-8072-4476, Frank, Stefan, Russ, Nicole, Trautwein, Jonathan, van Bon, Bregje, Gilissen, Christian
ORCID: 0000-0003-1693-9699, Laugsch, Magdalena, Gusmao, Eduardo Gade, Josipovic, Natasa
ORCID: 0000-0001-7683-0869, Altmueller, Janine, Nuernberg, Peter, Laengst, Gernot, Kaiser, Frank J., Watrin, Erwan, Brunner, Han, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341, Kurian, Leo
ORCID: 0000-0001-7466-5169, Wollnik, Bernd
ORCID: 0000-0003-2589-0364, Bouazoune, Karim and Papantonis, Argyris
(2021).
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology.
Nat. Commun., 12 (1).
BERLIN:
NATURE RESEARCH.
ISSN 2041-1723
Koester, Janis ORCID: 0000-0002-5274-0591, Miroshnikova, Yekaterina A., Ghatak, Sushmita, Chacon-Martinez, Carlos Andres, Morgner, Jessica
ORCID: 0000-0001-6374-8639, Li, Xinping
ORCID: 0000-0002-7427-0017, Atanassov, Ilian
ORCID: 0000-0001-8259-2545, Altmueller, Janine, Birk, David E., Koch, Manuel
ORCID: 0000-0002-2962-7814, Bloch, Wilhelm, Bartusel, Michaela, Niessen, Carien M.
ORCID: 0000-0002-4892-9391, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341 and Wickstroem, Sara A.
(2021).
Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility.
Nat. Cell Biol., 23 (7).
S. 771 - 797.
BERLIN:
NATURE RESEARCH.
ISSN 1476-4679
Pachano, Tomas, Sanchez-Gaya, Victor, Ealo, Thais, Mariner-Fauli, Maria, Bleckwehl, Tore, Asenjo, Helena G., Respuela, Patricia, Cruz-Molina, Sara, Munoz-San Martin, Maria, Haro, Endika, van IJcken, Wilfred F. J., Landeira, David ORCID: 0000-0002-3267-454X and Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341
(2021).
Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness.
Nature Genet., 53 (7).
S. 1036 - 1074.
BERLIN:
NATURE RESEARCH.
ISSN 1546-1718
Thues, Cedric, Valadas, Jorge S., Deaulmerie, Liesbeth, Geens, Ann, Chouhan, Amit K., Duran-Romana, Ramon ORCID: 0000-0002-2020-8672, Schymkowitz, Joost, Rousseau, Frederic, Bartusel, Michaela, Rehimi, Rizwan, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341, Verstreken, Patrik
ORCID: 0000-0002-5073-5393 and Van Esch, Hilde
(2021).
MAPRE2 mutations result in altered human cranial neural crest migration, underlying craniofacial malformations in CSC-KT syndrome.
Sci Rep, 11 (1).
BERLIN:
NATURE RESEARCH.
ISSN 2045-2322
2020
Bastida, Maria Felix, Perez-Gomez, Rocio, Trofka, Anna, Zhu, Jianjian, Rada-Iglesias, Alvaro, Sheth, Rushikesh, Stadler, H. Scott, Mackem, Susan and Ros, Marian A. (2020). The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc. Natl. Acad. Sci. U. S. A., 117 (2). S. 1090 - 1097. WASHINGTON: NATL ACAD SCIENCES. ISSN 0027-8424
Boles, Nathan C., Fernandes, Marie, Swigut, Tomasz, Srinivasan, Rajini, Schiff, Lauren ORCID: 0000-0003-2438-2456, Rada-Iglesias, Alvaro, Wang, Qingjie, Saini, Janmeet S., Kiehl, Thomas, Stern, Jeffrey H., Wysocka, Joanna, Blenkinsop, Timothy A. and Temple, Sally
(2020).
Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide.
Stem Cell Rep., 14 (4).
S. 631 - 648.
CAMBRIDGE:
CELL PRESS.
ISSN 2213-6711
Fatima, Azra, Irmak, Dilber, Noormohammadi, Alireza, Rinschen, Markus M., Das, Aniruddha ORCID: 0000-0002-7704-3573, Leidecker, Orsolya, Schindler, Christina, Sanchez-Gaya, Victor, Wagle, Prerana, Pokrzywa, Wojciech
ORCID: 0000-0002-5110-4462, Hoppe, Thorsten
ORCID: 0000-0002-4734-9352, Rada-Iglesias, Alvaro and Vilchez, David
(2020).
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells.
Commun. Biol., 3 (1).
NEW YORK:
NATURE PUBLISHING GROUP.
ISSN 2399-3642
Sanchez-Gaya, Victor, Mariner-Fauli, Maria and Rada-Iglesias, Alvaro (2020). Rare or Overlooked? Structural Disruption of Regulatory Domains in Human Neurocristopathies. Front. Genet., 11. LAUSANNE: FRONTIERS MEDIA SA. ISSN 1664-8021
2019
Bleckwehl, Tore and Rada-Iglesias, Alvaro (2019). Transcriptional and epigenetic control of germline competence and specification. Curr. Opin. Cell Biol., 61. S. 1 - 9. LONDON: CURRENT BIOLOGY LTD. ISSN 1879-0410
Frank, Stefan, Ahuja, Gaurav ORCID: 0000-0002-2837-9361, Bartsch, Deniz, Russ, Nicole, Yao, Wenjie, Kuo, Joseph Chao-Chung, Derks, Jens-Peter, Akhade, Vijay Suresh, Kargapolova, Yulia, Georgomanolis, Theodore, Messling, Jan-Erik
ORCID: 0000-0003-3843-0041, Gramm, Marie, Brant, Lilija, Rehimi, Rizwan, Vargas, Natalia Emilse, Kuroczik, Alina, Yang, Tsun-Po, Sahito, Raja Ghazanfar Ali, Franzen, Julia, Hescheler, Juergen, Sachinidis, Agapios, Peifer, Martin, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341, Kanduri, Meena, Costa, Ivan G.
ORCID: 0000-0003-2890-8697, Kanduri, Chandrasekhar, Papantonis, Argyris
ORCID: 0000-0001-7551-1073 and Kurian, Leo
ORCID: 0000-0001-7466-5169
(2019).
yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.
Cell Stem Cell, 24 (2).
S. 318 - 336.
CAMBRIDGE:
CELL PRESS.
ISSN 1875-9777
Laugsch, Magdalena, Bartusel, Michaela, Rehimi, Rizwan, Alirzayeva, Hafiza, Karaolidou, Agathi, Crispatzu, Giuliano, Zentis, Peter, Nikolic, Milos ORCID: 0000-0003-0029-7601, Bleckwehl, Tore, Kolovos, Petros
ORCID: 0000-0002-0787-6158, van Ijcken, Wilfred F. J., Saric, Tomo, Koehler, Katrin, Frommolt, Peter
ORCID: 0000-0002-1966-8014, Lachlan, Katherine, Baptista, Julia and Rada-Iglesias, Alvaro
(2019).
Modeling the Pathological Long-Range Regulatory Effects of Human Structural Variation with Patient-Specific hiPSCs.
Cell Stem Cell, 24 (5).
S. 736 - 765.
CAMBRIDGE:
CELL PRESS.
ISSN 1875-9777
Matheus, Friederike, Rusha, Ejona, Rehimi, Rizwan, Molitor, Lena, Pertek, Anna, Modic, Miha, Feederle, Regina, Flatley, Andrew, Kremmer, Elisabeth, Geerlof, Arie, Rishko, Valentyna, Rada-Iglesias, Alvaro and Drukker, Micha (2019). Pathological ASXL1 Mutations and Protein Variants Impair Neural Crest Development. Stem Cell Rep., 12 (5). S. 861 - 869. CAMBRIDGE: CELL PRESS. ISSN 2213-6711
Pachano, Tomas, Crispatzu, Giuliano and Rada-Iglesias, Alvaro (2019). Polycomb proteins as organizers of 3D genome architecture in embryonic stem cells. Brief. Funct. Genomics, 18 (6). S. 358 - 367. OXFORD: OXFORD UNIV PRESS. ISSN 2041-2657
Zanella, Matteo ORCID: 0000-0002-1614-4370, Vitriolo, Alessandro
ORCID: 0000-0002-1462-8064, Andirko, Alejandro, Tiago Martins, Pedro, Sturm, Stefanie, O'Rourke, Thomas
ORCID: 0000-0003-2231-8450, Laugsch, Magdalena, Malerba, Natascia
ORCID: 0000-0003-0714-3314, Skaros, Adrianos, Trattaro, Sebastiano
ORCID: 0000-0002-3142-6747, Germain, Pierre-Luc, Mihailovic, Marija
ORCID: 0000-0001-7478-2509, Merla, Giuseppe, Rada-Iglesias, Alvaro, Boeckx, Cedric and Testa, Giuseppe
(2019).
Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication.
Sci. Adv., 5 (12).
WASHINGTON:
AMER ASSOC ADVANCEMENT SCIENCE.
ISSN 2375-2548
2018
Fernandes, Marie, Schiff, Lauren, Swigut, Tomasz, Boles, Nathan, Srinivasan, Rajini, Rada-Iglesias, Alvaro, Wang, Qingjie, Saini, Janmeet, Kiehl, Tom, Stern, Jeffrey, Wysocka, Joanna, Temple, Sally and Blenkinsop, Timothy A. (2018). Nicotinamide protects against PVR by preventing RPE cells to undergo EMT. Invest. Ophthalmol. Vis. Sci., 59 (9). ROCKVILLE: ASSOC RESEARCH VISION OPHTHALMOLOGY INC. ISSN 1552-5783
Fueyo, Raquel, Iacobucci, Simona, Pappa, Stella, Estaras, Conchi ORCID: 0000-0002-2600-5841, Lois, Sergio, Vicioso-Mantis, Marta, Navarro, Claudia, Cruz-Molina, Sara, Carlos Reyes, Jose, Rada-Iglesias, Alvaro, de la Cruz, Xavier and Martinez-Balbas, Marian A.
(2018).
Lineage specific transcription factors and epigenetic regulators mediate TGF beta-dependent enhancer activation.
Nucleic Acids Res., 46 (7).
S. 3351 - 3366.
OXFORD:
OXFORD UNIV PRESS.
ISSN 1362-4962
Irmak, Dilber, Fatima, Azra, Gutierrez-Garcia, Ricardo, Rinschen, Markus M., Wagle, Prerana, Altmueller, Janine, Arrigoni, Laura, Hummel, Barbara ORCID: 0000-0001-6563-3675, Klein, Corinna, Frese, Christian K., Sawarkar, Ritwick, Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341 and Vilchez, David
ORCID: 0000-0002-0801-0743
(2018).
Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations.
Hum. Mol. Genet., 27 (23).
S. 4117 - 4135.
OXFORD:
OXFORD UNIV PRESS.
ISSN 1460-2083
Rada-Iglesias, Alvaro (2018). Is H3K4me1 at enhancers correlative or causative? Nature Genet., 50 (1). S. 4 - 7. NEW YORK: NATURE PUBLISHING GROUP. ISSN 1546-1718
Rada-Iglesias, Alvaro (2018). Pioneering of Enhancer Landscapes during Pluripotent State Transitions. Cell Stem Cell, 23 (2). S. 149 - 152. CAMBRIDGE: CELL PRESS. ISSN 1875-9777
Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341, Grosveld, Frank G. and Papantonis, Argyris
ORCID: 0000-0001-7551-1073
(2018).
Forces driving the three-dimensional folding of eukaryotic genomes.
Mol. Syst. Biol., 14 (6).
HOBOKEN:
WILEY.
ISSN 1744-4292
2017
Cruz-Molina, Sara, Respuela, Patricia ORCID: 0000-0002-9719-7860, Tebartz, Christina, Kolovos, Petros
ORCID: 0000-0002-0787-6158, Nikolic, Milos
ORCID: 0000-0003-0029-7601, Fueyo, Raquel, van Ijcken, Wilfred F. J., Grosveld, Frank, Frommolt, Peter
ORCID: 0000-0002-1966-8014, Bazzi, Hisham
ORCID: 0000-0001-8388-4005 and Rada-Iglesias, Alvaro
(2017).
PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation.
Cell Stem Cell, 20 (5).
S. 689 - 715.
CAMBRIDGE:
CELL PRESS.
ISSN 1875-9777
Ludwig, Kerstin U., Boehmer, Anne C., Bowes, John, Nikolic, Milos ORCID: 0000-0003-0029-7601, Ishorst, Nina, Wyatt, Niki, Hammond, Nigel L., Goelz, Lina, Thieme, Frederic, Barth, Sandra, Schuenke, Hannah, Klamt, Johanna, Spielmann, Malte
ORCID: 0000-0002-0583-4683, Aldhorae, Khalid
ORCID: 0000-0002-5920-8004, Rojas-Martinez, Augusto, Noethen, Markus M., Rada-Iglesias, Alvaro, Dixon, Michael J., Knapp, Michael and Mangold, Elisabeth
(2017).
Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip 6 cleft palate and cleft palate only.
Hum. Mol. Genet., 26 (4).
S. 829 - 843.
OXFORD:
OXFORD UNIV PRESS.
ISSN 1460-2083
Nikolic, Milos ORCID: 0000-0003-0029-7601, Papantonis, Argyris
ORCID: 0000-0001-7551-1073 and Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341
(2017).
GARLIC: a bioinformatic toolkit for aetiologically connecting diseases and cell type-specific regulatory maps.
Hum. Mol. Genet., 26 (4).
S. 742 - 753.
OXFORD:
OXFORD UNIV PRESS.
ISSN 1460-2083
Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341
(2017).
Ready, Set. . .Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation.
Mol. Syst. Biol., 13 (10).
HOBOKEN:
WILEY.
ISSN 1744-4292
Rehimi, Rizwan, Bartusel, Michaela, Solinas, Francesca, Altmueller, Janine and Rada-Iglesias, Alvaro (2017). Chromatin Immunoprecipitation (ChIP) Protocol for Low-abundance Embryonic Samples. J. Vis. Exp. (126). CAMBRIDGE: JOURNAL OF VISUALIZED EXPERIMENTS. ISSN 1940-087X
2016
Lu, Rong, Rada-Iglesias, Alvaro and Phillips-Cremins, Jennifer ORCID: 0000-0002-4702-0450
(2016).
The Path to My Lab's First Paper: Rong Lu, Alvaro Rada-Iglesias, and Jennifer Phillips-Cremins.
Cell Stem Cell, 19 (6).
S. 683 - 686.
CAMBRIDGE:
CELL PRESS.
ISSN 1875-9777
Rehimi, Rizwan, Nikolic, Milos ORCID: 0000-0003-0029-7601, Cruz-Molina, Sara, Tebartz, Christina, Frommolt, Peter
ORCID: 0000-0002-1966-8014, Mahabir, Esther, Clement-Ziza, Mathieu
ORCID: 0000-0003-2763-249X and Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341
(2016).
Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations.
Cell Reports, 17 (11).
S. 3062 - 3077.
CAMBRIDGE:
CELL PRESS.
ISSN 2211-1247
Respuela, Patricia ORCID: 0000-0002-9719-7860, Nikolic, Milos
ORCID: 0000-0003-0029-7601, Tan, Minjia
ORCID: 0000-0002-6784-9653, Frommolt, Peter
ORCID: 0000-0002-1966-8014, Zhao, Yingming, Wysocka, Joanna and Rada-Iglesias, Alvaro
ORCID: 0000-0001-7137-1341
(2016).
Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification.
Cell Stem Cell, 18 (1).
S. 118 - 134.
CAMBRIDGE:
CELL PRESS.
ISSN 1875-9777
Respuela, Patricia and Rada-Iglesias, Alvaro (2016). Enhancer Remodeling During Early Mammalian Embryogenesis: Lessons for Somatic Reprogramming, Rejuvenation, and Aging. Curr. Stem. Cell Rep., 2 (3). S. 263 - 273. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 2198-7866
2014
Rada-Iglesias, Alvaro ORCID: 0000-0001-7137-1341
(2014).
Genetic variation within transcriptional regulatory elements and its implications for human disease.
Biol. Chem., 395 (12).
S. 1453 - 1461.
BERLIN:
WALTER DE GRUYTER GMBH.
ISSN 1437-4315