Universität zu Köln

Journal Article

Delaunay, Sylvain, Rapino, Francesca ORCID: 0000-0002-4343-3805, Tharun, Lars, Zhou, Zhaoli, Heukamp, Lukas ORCID: 0000-0002-3388-3482, Termathe, Martin ORCID: 0000-0002-5618-4633, Shostak, Kateryna, Klevernic, Iva, Florin, Alexandra, Desmecht, Hadrien, Desmet, Christophe J., Nguyen, Laurent ORCID: 0000-0002-8560-3008, Leidel, Sebastian A., Willis, Anne E., Buettner, Reinhard, Chariot, Alain and Close, Pierre (2016). Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. J. Exp. Med., 213 (11). S. 2503 - 2524. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-9538

Dietlein, Felix, Kalb, Bastian, Jokic, Mladen, Noll, Elisa M., Strong, Alexander, Tharun, Lars, Ozretic, Luka, Kuenstlinger, Helen, Kambartel, Kato, Randerath, Winfried J., Juengst, Christian, Schmitt, Anna, Torgovnick, Alessandro, Richters, Andre, Rauh, Daniel ORCID: 0000-0002-1970-7642, Siedek, Florian, Persigehl, Thorsten, Mauch, Cornelia, Bartkova, Jirina, Bradley, Allan ORCID: 0000-0002-2349-8839, Sprick, Martin R. ORCID: 0000-0001-9691-7574, Trumpp, Andreas ORCID: 0000-0002-6212-3466, Rad, Roland, Saur, Dieter ORCID: 0000-0001-5874-0210, Bartek, Jiri, Wolf, Juergen, Buettner, Reinhard, Thomas, Roman K. and Reinhardt, H. Christian (2015). A Synergistic Interaction between Chk1-and MK2 Inhibitors in KRAS-Mutant Cancer. Cell, 162 (1). S. 146 - 160. CAMBRIDGE: CELL PRESS. ISSN 1097-4172

Fischer, Janina, Simon, Thorsten, Hamprecht, Axel ORCID: 0000-0003-1449-5780, Hos, Nina, Moericke, Anja, Cernaianu, Grigore, Tharun, Lars, Gruhn, Bernd, Plum, Georg and Duebbers, Martin (2018). Surgical Implications for Diagnosis and Treatment of Intestinal Aspergillosis in Pediatric Patients with ALL. Eur. J. Pediatr. Surg., 28 (6). S. 477 - 484. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-359X

Golfmann, Kristina, Meder, Lydia ORCID: 0000-0002-9547-5812, Koker, Mirjam, Volz, Caroline, Borchmann, Sven, Tharun, Lars, Dietlein, Felix, Malchers, Florian, Florin, Alexandra, Buettner, Reinhard, Rosen, Neal, Rodrik-Outmezguine, Vanessa, Hallek, Michael and Ullrich, Roland T. (2018). Synergistic anti-angiogenic treatment effects by dual FGFR1 and VEGFR1 inhibition in FGFR1-amplified breast cancer. Oncogene, 37 (42). S. 5682 - 5694. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5594

Koelsche, Christian ORCID: 0000-0001-8763-8864, Schrimpf, Daniel, Tharun, Lars, Roth, Eva, Sturm, Dominik ORCID: 0000-0003-0250-1696, Jones, David T. W., Renker, Eva-Kristin, Sill, Martin, Baude, Annika, Sahm, Felix ORCID: 0000-0001-5441-1962, Capper, David ORCID: 0000-0003-1945-497X, Bewerunge-Hudler, Melanie, Hartmann, Wolfgang ORCID: 0000-0002-7609-5021, Kulozik, Andreas E., Petersen, Iver, Flucke, Uta, Schreuder, Hendrik W. B., Buettner, Reinhard, Weber, Marc-Andre, Schirmacher, Peter, Plass, Christoph, Pfister, Stefan M., von Deimling, Andreas ORCID: 0000-0002-5863-540X and Mechtersheimer, Gunhild (2017). Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases. Clin. Sarcoma Res., 7. LONDON: BMC. ISSN 2045-3329

Ladang, Aurelie, Rapino, Francesca ORCID: 0000-0002-4343-3805, Heukamp, Lukas C., Tharun, Lars, Shostak, Kateryna, Hermand, Damien, Delaunay, Sylvain ORCID: 0000-0003-1077-829X, Klevernic, Iva, Jiang, Zheshen ORCID: 0000-0002-4914-7041, Jacques, Nicolas, Jamart, Diane, Migeot, Valerie, Florin, Alexandra, Goktuna, Serkan ORCID: 0000-0001-6169-768X, Malgrange, Brigitte, Sansom, Owen J. ORCID: 0000-0001-9540-3010, Nguyen, Laurent ORCID: 0000-0002-8560-3008, Buettner, Reinhard, Close, Pierre and Chariot, Alain (2015). Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. J. Exp. Med., 212 (12). S. 2057 - 2076. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-9538

Lechner, Axel, Schloesser, Hans, Rothschild, Sacha I., Thelen, Martin ORCID: 0000-0002-2785-9726, Reuter, Sabrina, Zentis, Peter, Shimabukuro-Vornhagen, Alexander, Theurich, Sebastian ORCID: 0000-0001-5706-8258, Wennhold, Kerstin ORCID: 0000-0001-5539-7226, Garcia-Marquez, Maria, Tharun, Lars, Quaas, Alexander, Schauss, Astrid, Isensee, Joerg ORCID: 0000-0002-3390-0051, Hucho, Tim ORCID: 0000-0002-4147-9308, Huebbers, Christian ORCID: 0000-0002-2934-1218, von Bergwelt-Baildon, Michael and Beutner, Dirk (2017). Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma. Oncotarget, 8 (27). S. 44418 - 44434. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

Loeser, Heike, Schallenberg, Simon, von Winterfeld, Moritz, Tharun, Lars, Alakus, Hakan, Hoelscher, Arnulf, Bollschweiler, Elfriede, Buettner, Reinhard, Zander, Thomas and Quaas, Alexander (2017). High protein and mRNA expression levels of TUBB3 (class III beta-tubulin) are associated with aggressive tumor features in esophageal adenocarcinomas. Oncotarget, 8 (70). S. 115179 - 115190. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

Nemazanyy, Ivan, Rambow, Florian, Tang, Seng Chuan, Delaunay, Sylvain, Tharun, Lars, Florin, Alexandra, Buttner, Reinhard, Vandaele, Daniel, Close, Pierre, Marine, Jean-Christophe ORCID: 0000-0003-2433-9837, Shostak, Kateryna and Chariot, Alain (2018). The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids. Cancer Res., 78 (16). S. 4533 - 4549. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Offermann, Anne, Joerg, Vincent, Becker, Finn, Roesch, Marie C., Kang, Duan, Lemster, Anna-Lena, Tharun, Lars, Behrends, Jochen ORCID: 0000-0002-0648-8911, Merseburger, Axel S., Culig, Zoran, Sailer, Verena, Braegelmann, Johannes, Kirfel, Jutta and Perner, Sven (2022). Inhibition of Cyclin-Dependent Kinase 8/Cyclin-Dependent Kinase 19 Suppresses Its Pro-Oncogenic Effects in Prostate Cancer. Am. J. Pathol., 192 (5). S. 813 - 824. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1525-2191

Offermann, Anne, Joerg, Vincent, Hupe, Marie C., Becker, Finn, Mueller, Marten, Braegelmann, Johannes, Kirfel, Jutta, Merseburger, Axel S., Sailer, Verena, Tharun, Lars and Perner, Sven (2021). CDK19 as a diagnostic marker for high-grade prostatic intraepithelial neoplasia. Hum. Pathol., 117. S. 60 - 68. PHILADELPHIA: W B SAUNDERS CO-ELSEVIER INC. ISSN 1532-8392

Ortiz-Cuaran, Sandra, Fernandez-Cuesta, Lynnette ORCID: 0000-0002-0724-6703, Lovly, Christine M., Bos, Marc, Scheffler, Matthias, Michels, Sebastian, Albus, Kerstin, Meyer, Lydia, Koenig, Katharina, Dahmen, Ilona, Mueller, Christian, Ozretic, Luca, Tharun, Lars, Schaub, Philipp, Florin, Alexandra, Pinther, Berit, Bahlmann, Nike, Ansen, Sascha, Peifer, Martin, Heukamp, Lukas C., Buettner, Reinhard, Sos, Martin L., Wolf, Juergen, Pao, William and Thomas, Roman K. (2015). Elucidating the mechanisms of acquired resistance in lung adenocarcinomas. Cancer Res., 75. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Rapino, Francesca ORCID: 0000-0002-4343-3805, Delaunay, Sylvain, Rambow, Florian, Zhou, Zhaoli, Tharun, Lars, De Tullio, Pascal, Sin, Olga ORCID: 0000-0002-0976-0570, Shostak, Kateryna, Schmitz, Sebastian, Piepers, Jolanda, Ghesquiere, Bart ORCID: 0000-0003-1547-1705, Karim, Latifa, Charloteaux, Benoit, Jamart, Diane, Florin, Alexandra, Lambert, Charles, Rorive, Andree, Jerusalem, Guy, Leucci, Eleonora ORCID: 0000-0002-2898-748X, Dewaele, Michael, Vooijs, Marc, Leidel, Sebastian A., Georges, Michel, Voz, Marianne, Peers, Bernard, Buettner, Reinhard, Marine, Jean-Christophe ORCID: 0000-0003-2433-9837, Chariot, Alain and Close, Pierre (2018). Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 558 (7711). S. 605 - 636. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-4687

Schiffmann, Lars M., Loeser, Heike ORCID: 0000-0003-4555-1327, Jacob, Anne Sophie, Maus, Martin, Fuchs, Hans, Zhao, Yue, Tharun, Lars, Essakly, Ahlem, Damanakis, Alexander Iannos, Zander, Thomas, Buettner, Reinhard, Schroeder, Wolfgang, Bruns, Christiane, Quaas, Alexander and Gebauer, Florian (2020). Dickkopf-2 (DKK2) as Context Dependent Factor in Patients with Esophageal Adenocarcinoma. Cancers, 12 (2). BASEL: MDPI. ISSN 2072-6694

Schulze, Kornelius, Weismueller, Tobias J., Bubenheim, Michael, Huebener, Peter ORCID: 0000-0001-7558-7625, Zenouzi, Roman, Lenzen, Henrike, Rupp, Christian, Gotthardt, Daniel, de Leuw, Philipp, Teufel, Andreas, Zimmer, Vincent ORCID: 0000-0002-6298-4717, Reiter, Florian P., Rust, Christian, Tharun, Lars, Quaas, Alexander, Weidemann, Soern A., Lammert, Frank, Sarrazin, Christoph, Manns, Michael P., Lohse, Ansgar W. and Schramm, Christoph ORCID: 0000-0002-4264-1928 (2015). Criteria Used in Clinical Practice to Guide Immunosuppressive Treatment in Patients with Primary Sclerosing Cholangitis. PLoS One, 10 (10). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

Shostak, Kateryna, Jiang, Zheshen, Charloteaux, Benoit, Mayer, Alice, Habraken, Yvette, Tharun, Lars, Klein, Sebastian ORCID: 0000-0002-2188-9377, Xu, Xinyi, Vislovukh, Andrii, Close, Pierre, Florin, Alexandra, Rambow, Florian, Marine, Jean-Christophe ORCID: 0000-0003-2433-9837, Buettner, Reinhard and Chariot, Alain (2020). The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage. Nat. Commun., 11 (1). LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

Tharun, Lars, Scheel, Andreas H., Zander, Thomas, Alakus, Hakan, Buettner, Reinhard and Quaas, Alexander (2016). PD-L1 status in esophageal carcinoma at the mRNA and protein level. J. Clin. Oncol., 34 (15). ALEXANDRIA: AMER SOC CLINICAL ONCOLOGY. ISSN 1527-7755

Tharun, Lars, Steuer, Stefan and Quaas, Alexander (2016). Role of pathologists with respect to therapy decisions for gastric cancer. Onkologe, 22 (6). S. 400 - 406. NEW YORK: SPRINGER. ISSN 1433-0415

Torgovnick, Alessandro, Heger, Jan Michel, Liaki, Vasiliki, Isensee, Joerg ORCID: 0000-0002-3390-0051, Schmitt, Anna, Knittel, Gero, Riabinska, Arina, Beleggia, Filippo ORCID: 0000-0003-0234-7094, Laurien, Lucie, Leeser, Uschi, Juengst, Christian, Siedek, Florian, Vogel, Wenzel, Kluemper, Niklas, Nolte, Hendrik, Wittersheim, Maike, Tharun, Lars, Castiglione, Roberta ORCID: 0000-0002-9828-4405, Krueger, Marcus, Schauss, Astrid, Perner, Sven, Pasparakis, Manolis ORCID: 0000-0002-9870-0966, Buettner, Reinhard, Persigehl, Thorsten, Hucho, Tim, Herter-Sprie, Grit Sophie, Schumacher, Bjoern and Reinhardt, Hans Christian (2018). The Cdkn1a(SuPER) Mouse as a Tool to Study p53-Mediated Tumor Suppression. Cell Reports, 25 (4). S. 1027 - 1046. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Walch-Rueckheim, Barbara, Pahne-Zeppenfeld, Jennifer, Fischbach, Jil, Wickenhauser, Claudia, Horn, Lars Christian, Tharun, Lars, Buettner, Reinhard, Mallmann, Peter, Stern, Peter, Kim, Yoo-Jin, Bohle, Rainer Maria, Ruebe, Christian, Stroeder, Russalina, Juhasz-Boess, Ingolf, Solomayer, Erich-Franz and Smola, Sigrun (2016). STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs. Cancer Res., 76 (13). S. 3872 - 3884. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1538-7445

Watermann, Christian ORCID: 0000-0002-6960-5863, Pasternack, Helen ORCID: 0000-0003-2386-2300, Idel, Christian, Ribbat-Idel, Julika, Braegelmann, Johannes, Kuppler, Patrick, Offermann, Anne, Jonigk, Danny, Kuehnel, Mark, Schroeck, Andreas, Dreyer, Eva, Rosero, Christian, Nathansen, Jacqueline, Dubrovska, Anna, Tharun, Lars, Kirfel, Jutta, Wollenberg, Barbara, Perner, Sven and Krupar, Rosemarie (2021). Recurrent HNSCC Harbor an Immunosuppressive Tumor Immune Microenvironment Suggesting Successful Tumor Immune Evasion. Clin. Cancer Res., 27 (2). S. 632 - 645. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. ISSN 1557-3265