Universität zu Köln

Journal Article

Tatsuta, Takashi and Langer, Thomas ORCID: 0000-0003-1250-1462 (2017). Intramitochondrial phospholipid trafficking. Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1862 (1). S. 81 - 90. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1879-2618

Hartmann, Bianca, Wai, Timothy ORCID: 0000-0002-6770-6222, Hu, Hao, MacVicar, Thomas, Musante, Luciana, Fischer-Zirnsak, Bjoern, Stenzel, Werner, Graef, Ralph, van den Heuvel, Lambert, Ropers, Hans-Hilger, Wienker, Thomas F., Huebner, Christoph, Langer, Thomas ORCID: 0000-0003-1250-1462 and Kaindl, Angela M. (2016). Homozygous YME1L1 Mutation Causes Mitochondriopathy with Optic Atrophy and Mitochondrial Network Fragmentation. eLife, 5. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

Korwitz, Anne, Merkwirth, Carsten ORCID: 0000-0001-8895-3495, Richter-Dennerlein, Ricarda, Troeder, Simon E., Sprenger, Hans-Georg, Quiros, Pedro M., Lopez-Otin, Carlos ORCID: 0000-0001-6964-1904, Rugarli, Elena I. ORCID: 0000-0002-5782-1067 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2016). Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J. Cell Biol., 212 (2). S. 157 - 167. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

Aaltonen, Mari J., Friedman, Jonathan R., Osman, Christof, Salin, Benedicte, Di Rago, Jean-Paul, Nunnari, Jodi, Langer, Thomas ORCID: 0000-0003-1250-1462 and Tatsuta, Takashi (2016). MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria. J. Cell Biol., 213 (5). S. 525 - 535. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

Wai, Timothy ORCID: 0000-0002-6770-6222 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2016). Mitochondrial Dynamics and Metabolic Regulation. Trends Endocrinol. Metab., 27 (2). S. 105 - 118. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1879-3061

MacVicar, Thomas and Langer, Thomas ORCID: 0000-0003-1250-1462 (2016). OPA1 processing in cell death and disease - the long and short of it. J. Cell Sci., 129 (12). S. 2297 - 2307. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9137

Koenig, Tim, Troeder, Simon E., Bakka, Kavya, Korwitz, Anne, Richter-Dennerlein, Ricarda, Lampe, Philipp A., Patron, Maria, Muhlmeister, Mareike, Guerrero-Castillo, Sergio ORCID: 0000-0002-6630-0562, Brandt, Ulrich ORCID: 0000-0003-1869-6811, Decker, Thorsten, Lauria, Ines ORCID: 0000-0001-5813-3103, Paggio, Angela, Rizzuto, Rosario ORCID: 0000-0001-7044-5097, Rugarli, Elena I. ORCID: 0000-0002-5782-1067, De Stefani, Diego ORCID: 0000-0003-3796-8907 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2016). The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria. Mol. Cell, 64 (1). S. 148 - 163. CAMBRIDGE: CELL PRESS. ISSN 1097-4164

Wai, Timothy ORCID: 0000-0002-6770-6222, Garcia-Prieto, Jaime, Baker, Michael J., Merkwirth, Carsten ORCID: 0000-0001-8895-3495, Benit, Paule, Rustin, Pierre, Javier Ruperez, Francisco, Barbas, Coral ORCID: 0000-0003-4722-491X, Ibanez, Borja ORCID: 0000-0002-5036-254X and Langer, Thomas ORCID: 0000-0003-1250-1462 (2015). Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. Science, 350 (6265). WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 1095-9203

Ising, Christina ORCID: 0000-0002-7267-3488, Koehler, Sybille, Braehler, Sebastian, Merkwirth, Carsten ORCID: 0000-0001-8895-3495, Hoehne, Martin, Baris, Olivier R., Hagmann, Henning, Kann, Martin, Fabretti, Francesca, Dafinger, Claudia, Bloch, Wilhelm, Schermer, Bernhard ORCID: 0000-0002-5194-9000, Linkermann, Andreas ORCID: 0000-0001-6287-9725, Bruening, Jens C., Kurschat, Christine E., Mueller, Roman-Ulrich, Wiesner, Rudolf J., Langer, Thomas ORCID: 0000-0003-1250-1462, Benzing, Thomas and Brinkkoetter, Paul Thomas (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol. Med., 7 (3). S. 275 - 288. HOBOKEN: WILEY. ISSN 1757-4684

Ising, Christina ORCID: 0000-0002-7267-3488, Koehler, Sybille, Braehler, Sebastian, Merkwirth, Carsten ORCID: 0000-0001-8895-3495, Hoehne, Martin, Baris, Olivier R., Hagmann, Henning, Kann, Martin, Fabretti, Francesca, Dafinger, Claudia, Bloch, Wilhelm, Schermer, Bernhard ORCID: 0000-0002-5194-9000, Linkermann, Andreas ORCID: 0000-0001-6287-9725, Bruening, Jens C., Kurschat, Christine E., Mueller, Roman-Ulrich, Wiesner, Rudolf J., Langer, Thomas ORCID: 0000-0003-1250-1462, Benzing, Thomas and Brinkkoetter, Paul Thomas (2015). Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure. EMBO Mol. Med., 7 (3). S. 275 - 288. HOBOKEN: WILEY. ISSN 1757-4684

Klecker, Till ORCID: 0000-0003-0149-042X, Wemmer, Megan, Haag, Mathias, Weig, Alfons, Boeckler, Stefan, Langer, Thomas ORCID: 0000-0003-1250-1462, Nunnari, Jodi and Westermann, Benedikt ORCID: 0000-0002-2991-1604 (2015). Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Sci Rep, 5. LONDON: NATURE PUBLISHING GROUP. ISSN 2045-2322

Miliara, Xeni, Garnett, James A., Tatsuta, Takashi, Abid Ali, Ferdos ORCID: 0000-0002-2903-3194, Baldie, Heather, Perez-Dorado, Inmaculada, Simpson, Peter, Yague, Ernesto, Langer, Thomas ORCID: 0000-0003-1250-1462 and Matthews, Stephen (2015). Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. EMBO Rep., 16 (7). S. 824 - 836. HOBOKEN: WILEY. ISSN 1469-3178

Bahat, Assaf, Perlberg, Shira, VIelamed-Book, Naomi, Isaac, Sara, Eden, Amir, Lauria, Ines ORCID: 0000-0001-5813-3103, Langer, Thomas ORCID: 0000-0003-1250-1462 and Orly, Joseph (2015). Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR). Mol. Cell. Endocrinol., 408 (C). S. 62 - 73. CLARE: ELSEVIER IRELAND LTD. ISSN 0303-7207

Mancini, Cecilia ORCID: 0000-0003-1282-0404, Orsi, Laura, Guo, Yiran, Li, Jiankang, Chen, Yulan, Wang, Fengxiang, Tian, Lifeng, Liu, Xuanzhu, Zhang, Jianguo, Jiang, Hui, Nmezi, Bruce Shike, Tatsuta, Takashi, Giorgio, Elisa ORCID: 0000-0003-4076-4649, Di Gregorio, Eleonora, Cavalieri, Simona, Pozzi, Elisa, Mortara, Paolo, Caglio, Maria Marcella, Balducci, Alessandro, Pinessi, Lorenzo, Langer, Thomas ORCID: 0000-0003-1250-1462, Padiath, Quasar S., Hakonarson, Hakon, Zhang, Xiuqing and Brusco, Alfredo ORCID: 0000-0002-8318-7231 (2015). An atypical form of AOA2 with myoclonus associated with mutations in SETX and AFG3L2. BMC Med. Genet., 16. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2350

Mancini, Cecilia ORCID: 0000-0003-1282-0404, Orsi, Laura, Guo, Yiran, Li, Jiankang, Chen, Yulan, Wang, Fengxiang, Tian, Lifeng, Liu, Xuanzhu, Zhang, Jianguo, Jiang, Hui, Nmezi, Bruce Shike, Tatsuta, Takashi, Giorgio, Elisa ORCID: 0000-0003-4076-4649, Di Gregorio, Eleonora, Cavalieri, Simona, Pozzi, Elisa, Mortara, Paolo, Caglio, Maria Marcella, Balducci, Alessandro, Pinessi, Lorenzo, Langer, Thomas ORCID: 0000-0003-1250-1462, Padiath, Quasar S., Hakonarson, Hakon, Zhang, Xiuqing and Brusco, Alfredo ORCID: 0000-0002-8318-7231 (2015). An atypical form of AOA2 with myoclonus associated with mutations in SETX and AFG3L2. BMC Med. Genet., 16. LONDON: BIOMED CENTRAL LTD. ISSN 1471-2350

Moncunill-Massaguer, Cristina, Saura-Esteller, Jose ORCID: 0000-0001-6924-7798, Perez-Perarnau, Alba, Mariela Palmeri, Claudia, Nunez-Vazquez, Sonia, Cosialls, Ana M., Gonzalez-Girones, Diana M., Pomares, Helena, Korwitz, Anne, Preciado, Sara, Albericio, Fernando, Lavilla, Rodolfo, Pons, Gabriel, Langer, Thomas ORCID: 0000-0003-1250-1462, Iglesias-Serret, Daniel ORCID: 0000-0001-8656-1308 and Gil, Joan ORCID: 0000-0002-3686-3903 (2015). A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation. Oncotarget, 6 (39). S. 41750 - 41766. ORCHARD PARK: IMPACT JOURNALS LLC. ISSN 1949-2553

Richter-Dennerlein, Ricarda, Korwitz, Anne, Haag, Mathias, Tatsuta, Takashi, Dargazanli, Sascha, Baker, Michael, Decker, Thorsten, Lamkemeyer, Tobias, Rugarli, Elena I. ORCID: 0000-0002-5782-1067 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling. Cell Metab., 20 (1). S. 158 - 172. CAMBRIDGE: CELL PRESS. ISSN 1932-7420

Escobar-Henriques, Mafalda ORCID: 0000-0002-0879-3119 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). Dynamic survey of mitochondria by ubiquitin. EMBO Rep., 15 (3). S. 231 - 244. HOBOKEN: WILEY. ISSN 1469-3178

Sepulveda-Falla, Diego ORCID: 0000-0003-0176-2042, Barrera-Ocampo, Alvaro ORCID: 0000-0003-0906-9293, Hagel, Christian, Korwitz, Anne, Vinueza-Veloz, Maria Fernanda, Zhou, Kuikui, Schonewille, Martijn, Zhou, Haibo, Velazquez-Perez, Luis, Rodriguez-Labrada, Roberto ORCID: 0000-0003-3193-7683, Villegas, Andres, Ferrer, Isidro, Lopera, Francisco, Langer, Thomas ORCID: 0000-0003-1250-1462, De Zeeuw, Chris I. and Glatzel, Markus ORCID: 0000-0002-7720-8817 (2014). Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. J. Clin. Invest., 124 (4). S. 1552 - 1568. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

Kondadi, Arun Kumar ORCID: 0000-0002-5888-7834, Wang, Shuaiyu, Montagner, Sara, Kladt, Nikolay, Korwitz, Anne, Martinelli, Paola, Herholz, David, Baker, Michael J., Schauss, Astrid C., Langer, Thomas ORCID: 0000-0003-1250-1462 and Rugarli, Elena I. ORCID: 0000-0002-5782-1067 (2014). Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation. Embo J., 33 (9). S. 1011 - 1027. HOBOKEN: WILEY. ISSN 1460-2075

Tatsuta, Takashi, Scharwey, Melanie and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). Mitochondrial lipid trafficking. Trends Cell Biol., 24 (1). S. 44 - 53. LONDON: ELSEVIER SCIENCE LONDON. ISSN 0962-8924

Almontashiri, Naif A. M., Chen, Hsiao-Huei ORCID: 0000-0003-2914-6057, Mailloux, Ryan J., Tatsuta, Takashi, Teng, Allen C. T., Mahmoud, Ahmad B., Ho, Tiffany, Stewart, Nicolas A. S., Rippstein, Peter, Harper, Mary Ellen, Roberts, Robert, Willenborg, Christina ORCID: 0000-0001-5217-6882, Erdmann, Jeanette ORCID: 0000-0002-4486-6231, Pastore, Annalisa, McBride, Heidi M., Langer, Thomas ORCID: 0000-0003-1250-1462 and Stewart, Alexandre F. R. (2014). SPG7 Variant Escapes Phosphorylation-Regulated Processing by AFG3L2, Elevates Mitochondrial ROS, and Is Associated with Multiple Clinical Phenotypes. Cell Reports, 7 (3). S. 834 - 848. CAMBRIDGE: CELL PRESS. ISSN 2211-1247

Bahat, Assaf, Perlberg, Shira, Melamed-Book, Naomi, Lauria, Ines ORCID: 0000-0001-5813-3103, Langer, Thomas ORCID: 0000-0003-1250-1462 and Orly, Joseph (2014). StAR Enhances Transcription of Genes Encoding the Mitochondrial Proteases Involved in Its Own Degradation. Mol. Endocrinol., 28 (2). S. 208 - 225. CARY: OXFORD UNIV PRESS INC. ISSN 1944-9917

Baker, Michael J., Lampe, Philipp A., Stojanovski, Diana ORCID: 0000-0002-0199-3222, Korwitz, Anne, Anand, Ruchika ORCID: 0000-0001-7337-6007, Tatsuta, Takashi and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics. Embo J., 33 (6). S. 578 - 594. HOBOKEN: WILEY. ISSN 1460-2075

Anand, Ruchika ORCID: 0000-0001-7337-6007, Wai, Timothy ORCID: 0000-0002-6770-6222, Baker, Michael J., Kladt, Nikolay, Schauss, Astrid C., Rugarli, Elena ORCID: 0000-0002-5782-1067 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2014). The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. J. Cell Biol., 204 (6). S. 919 - 930. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

Supale, Sachin, Thorel, Fabrizio, Merkwirth, Carsten ORCID: 0000-0001-8895-3495, Gjinovci, Asllan, Herrera, Pedro L., Scorrano, Luca ORCID: 0000-0002-8515-8928, Meda, Paolo, Langer, Thomas ORCID: 0000-0003-1250-1462 and Maechler, Pierre ORCID: 0000-0002-2005-1433 (2013). Loss of Prohibitin Induces Mitochondrial Damages Altering beta-Cell Function and Survival and Is Responsible for Gradual Diabetes Development. Diabetes, 62 (10). S. 3488 - 3500. ALEXANDRIA: AMER DIABETES ASSOC. ISSN 1939-327X

Scharwey, Melanie, Tatsuta, Takashi and Langer, Thomas ORCID: 0000-0003-1250-1462 (2013). Mitochondrial lipid transport at a glance. J. Cell Sci., 126 (23). S. 5317 - 5324. CAMBRIDGE: COMPANY OF BIOLOGISTS LTD. ISSN 1477-9137

Almajan, Eva R., Richter, Ricarda, Paeger, Lars ORCID: 0000-0001-8716-3483, Martinelli, Paola, Barth, Esther, Decker, Thorsten, Larsson, Nils-Goeran, Kloppenburg, Peter, Langer, Thomas ORCID: 0000-0003-1250-1462 and Rugarli, Elena I. (2012). AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival. J. Clin. Invest., 122 (11). S. 4048 - 4059. ANN ARBOR: AMER SOC CLINICAL INVESTIGATION INC. ISSN 1558-8238

Baker, Michael J., Mooga, Ved P., Guiard, Bernard, Langer, Thomas ORCID: 0000-0003-1250-1462, Ryan, Michael T. and Stojanovski, Diana ORCID: 0000-0002-0199-3222 (2012). Impaired Folding of the Mitochondria! Small TIM Chaperones Induces Clearance by the i-AAA Protease. J. Mol. Biol., 424 (5). S. 227 - 240. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1089-8638

Connerth, Melanie, Tatsuta, Takashi, Haag, Mathias, Klecker, Till ORCID: 0000-0003-0149-042X, Westermann, Benedikt ORCID: 0000-0002-2991-1604 and Langer, Thomas ORCID: 0000-0003-1250-1462 (2012). Intramitochondrial Transport of Phosphatidic Acid in Yeast by a Lipid Transfer Protein. Science, 338 (6108). S. 815 - 819. WASHINGTON: AMER ASSOC ADVANCEMENT SCIENCE. ISSN 0036-8075

Merkwirth, Carsten ORCID: 0000-0001-8895-3495, Martinelli, Paola, Korwitz, Anne, Morbin, Michela ORCID: 0000-0001-8034-3123, Broenneke, Hella S., Jordan, Sabine D., Rugarli, Elena I. and Langer, Thomas ORCID: 0000-0003-1250-1462 (2012). Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration. PLoS Genet., 8 (11). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7404

Klein, Julian M., Busch, Jakob D., Potting, Christoph, Baker, Michael J., Langer, Thomas ORCID: 0000-0003-1250-1462 and Schwarz, Guenter ORCID: 0000-0002-2118-9338 (2012). The Mitochondrial Amidoxime-reducing Component (mARC1) Is a Novel Signal-anchored Protein of the Outer Mitochondrial Membrane. J. Biol. Chem., 287 (51). S. 42795 - 42804. BETHESDA: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC. ISSN 1083-351X

Pierson, Tyler Mark, Adams, David, Bonn, Florian, Martinelli, Paola, Cherukuri, Praveen F., Teer, Jamie K., Hansen, Nancy F., Cruz, Pedro, Mullikin, James C., Blakesley, Robert W., Golas, Gretchen, Kwan, Justin, Sandler, Anthony ORCID: 0000-0001-9440-2964, Fajardo, Karin Fuentes, Markello, Thomas, Tifft, Cynthia, Blackstone, Craig, Rugarli, Elena I., Langer, Thomas ORCID: 0000-0003-1250-1462, Gahl, William A. and Toro, Camilo (2011). Whole-Exome Sequencing Identifies Homozygous AFG3L2 Mutations in a Spastic Ataxia-Neuropathy Syndrome Linked to Mitochondrial m-AAA Proteases. PLoS Genet., 7 (10). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1553-7390

Bruening, Jens, Langer, Thomas ORCID: 0000-0003-1250-1462 and Trifunovic, Aleksandra (2010). Highlight: The Biology of Aging: Mechanisms and Intervention. Biol. Chem., 391 (10). S. 1113 - 1114. BERLIN: WALTER DE GRUYTER & CO. ISSN 1431-6730