Hermanns, Thomas ORCID: 0000-0001-5350-7479 and Hofmann, Kay (2019). Bacterial DUBs: deubiquitination beyond the seven classes. Biochem. Soc. Trans., 47. S. 1857 - 1867. LONDON: PORTLAND PRESS LTD. ISSN 1470-8752
Full text not available from this repository.Abstract
Protein ubiquitination is a posttranslational modification that regulates many aspects of cellular life, including proteostasis, vesicular trafficking, DNA repair and NF-kappa B activation. By directly targeting intracellular bacteria or bacteria-containing vacuoles to the lysosome, ubiquitination is also an important component of cell-autonomous immunity. Not surprisingly, several pathogenic bacteria encode deubiquitinases (DUBs) and use them as secreted effectors that prevent ubiquitination of bacterial components. A systematic overview of known bacterial DUBs, including their cleavage specificities and biological roles, suggests multiple independent acquisition events from host-encoded DUBs and other proteases. The widely used classification of DUBs into seven well-defined families should only be applied to eukaryotic DUBs, since several bacterial DUBs do not follow this classification.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-125223 | ||||||||||||
DOI: | 10.1042/BST20190526 | ||||||||||||
Journal or Publication Title: | Biochem. Soc. Trans. | ||||||||||||
Volume: | 47 | ||||||||||||
Page Range: | S. 1857 - 1867 | ||||||||||||
Date: | 2019 | ||||||||||||
Publisher: | PORTLAND PRESS LTD | ||||||||||||
Place of Publication: | LONDON | ||||||||||||
ISSN: | 1470-8752 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Faculty of Mathematics and Natural Sciences | ||||||||||||
Divisions: | Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/12522 |
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