Korniy, Natalia, Samatova, Ekaterina, Anokhina, Maria M., Peske, Frank and Rodnina, Marina V. (2019). Mechanisms and biomedical implications of-1 programmed ribosome frameshifting on viral and bacterial mRNAs. FEBS Lett., 593 (13). S. 1468 - 1483. HOBOKEN: WILEY. ISSN 1873-3468
Full text not available from this repository.Abstract
Some proteins are expressed as a result of a ribosome frameshifting event that is facilitated by a slippery site and downstream secondary structure elements in the mRNA. This review summarizes recent progress in understanding mechanisms of -1 frameshifting in several viral genes, including IBV 1a/1b, HIV-1 gag-pol, and SFV 6K, and in Escherichia coli dnaX. The exact frameshifting route depends on the availability of aminoacyl-tRNAs: the ribosome normally slips into the -1-frame during tRNA translocation, but can also frameshift during decoding at condition when aminoacyl-tRNA is in limited supply. Different frameshifting routes and additional slippery sites allow viruses to maintain a constant production of their key proteins. The emerging idea that tRNA pools are important for frameshifting provides new direction for developing antiviral therapies.
Item Type: | Journal Article | ||||||||||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-136043 | ||||||||||||||||||||||||
DOI: | 10.1002/1873-3468.13478 | ||||||||||||||||||||||||
Journal or Publication Title: | FEBS Lett. | ||||||||||||||||||||||||
Volume: | 593 | ||||||||||||||||||||||||
Number: | 13 | ||||||||||||||||||||||||
Page Range: | S. 1468 - 1483 | ||||||||||||||||||||||||
Date: | 2019 | ||||||||||||||||||||||||
Publisher: | WILEY | ||||||||||||||||||||||||
Place of Publication: | HOBOKEN | ||||||||||||||||||||||||
ISSN: | 1873-3468 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/13604 |
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