Domroese, Christian M. and Mallmann, Peter (2019). Innovative treatments for metastasized cervical cancer. Gynakologe, 52 (8). S. 601 - 605. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0393
Full text not available from this repository.Abstract
Surgery, radiotherapy, and chemotherapy are the common treatment options for palliative therapy of metastatic cervical cancer. They are currently supplemented with innovative therapeutic options and will continue to be so the future. The vascular endothelial growth factor (VEGF) antibody bevacizumab-already approved for treatment of cervical cancer-interacts with tumor neoangiogenesis and can complement the effects of classical chemotherapy. At present, innovative therapies include drugs that do not attack the tumor itself but rather affect the immune system, such as immune checkpoint inhibitors. By inhibiting programmed cell death protein 1 (PD-1)/programmed death ligand 1 (PD-L1), e.g., with pembrolizumab, nivolumab, atezolizumab, or avelumab, T-cells and thus the own immune defense can be activated. Another immune checkpoint inhibitor is the anti-cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4) antibody (ipilimumab). Other targeted therapies include tyrosine kinase inhibitors, which are also being studied in the treatment of cervical cancer. In addition to the successful prophylactic vaccination against HPV, therapeutic vaccinations also represent a promising innovative therapeutic approach for the future treatment of metastatic cervical cancer.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-145746 | ||||||||||||
DOI: | 10.1007/s00129-019-4457-z | ||||||||||||
Journal or Publication Title: | Gynakologe | ||||||||||||
Volume: | 52 | ||||||||||||
Number: | 8 | ||||||||||||
Page Range: | S. 601 - 605 | ||||||||||||
Date: | 2019 | ||||||||||||
Publisher: | SPRINGER HEIDELBERG | ||||||||||||
Place of Publication: | HEIDELBERG | ||||||||||||
ISSN: | 1433-0393 | ||||||||||||
Language: | German | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/14574 |
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