Mattsson, Niklas, Groot, Colin, Jansen, Willemijn J., Landau, Susan M., Villemagne, Victor L., Engelborghs, Sebastiaan, Mintun, Mark M., Lleo, Alberto, Molinuevo, Jose Luis, Jagust, William J., Frisoni, Giovanni B., Ivanoiu, Adrian, Chetelat, Gael, de Oliveira, Catarina Resende, Rodrigue, Karen M., Kornhuber, Johannes ORCID: 0000-0002-8096-3987, Wallin, Anders, Klimkowicz-Mrowiec, Aleksandra, Kandimalla, Ramesh, Popp, Julius ORCID: 0000-0002-0068-0312, Aalten, Pauline P., Aarsland, Dag, Alcolea, Daniel ORCID: 0000-0002-3819-3245, Almdahl, Ina S., Baldeiras, Ines, van Buchem, Mark A., Cavedo, Enrica, Chen, Kewei, Cohen, Ann D., Foerster, Stefan, Fortea, Juan, Frederiksen, Kristian S., Freund-Levi, Yvonne ORCID: 0000-0001-6863-6679, Gill, Kiran Dip, Gkatzima, Olymbia, Grimmer, Timo, Hampel, Harald, Herukka, Sanna-Kaisa, Johannsen, Peter, van Laere, Koen, de Leon, Mony J., Maier, Wolfgang, Marcusson, Jan, Meulenbroek, Olga, Mollergard, Hanne M., Morris, John C., Mroczko, Barbara ORCID: 0000-0002-4075-8479, Nordlund, Arto, Prabhakar, Sudesh, Peters, Oliver, Rami, Lorena, Rodriguez-Rodriguez, Eloy ORCID: 0000-0001-7742-677X, Roe, Catherine M., Ruther, Eckart, Santana, Isabel, Schroder, Johannes, Seo, Sang W., Soininen, Hilkka, Spiru, Luiza, Stomrud, Erik, Struyfs, Hanne, Teunissen, Charlotte E., Verhey, Frans R. J., Vos, Stephanie J. B., van Doorn, Linda J. C. van Waalwijk, Waldemar, Gunhild, Wallin, Asa K., Wiltfang, Jens ORCID: 0000-0003-1492-5330, Vandenberghe, Rik ORCID: 0000-0001-6237-2502, Brooks, David J., Fladby, Tormod ORCID: 0000-0002-9984-9797, Rowe, Christopher C., Drzezga, Alexander, Verbeek, Marcel M., Sarazin, Marie, Wolk, David A., Fleisher, Adam S., Klunk, William E., Na, Duk L., Sanchez-Juan, Pascual, Lee, Dong Young, Nordberg, Agneta ORCID: 0000-0001-7345-5151, Tsolaki, Magda ORCID: 0000-0002-2072-8010, Camus, Vincent, Rinne, Juha O., Fagan, Anne M., Zetterberg, Henrik, Blennow, Kaj, Rabinovici, Gil D., Hansson, Oskar ORCID: 0000-0001-8467-7286, van Berckel, Bart N. M., van der Flier, Wiesje M., Scheltens, Philip ORCID: 0000-0002-1046-6408, Visser, Pieter Jelle ORCID: 0000-0001-8008-9727 and Ossenkoppele, Rik (2018). Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimer's disease. Alzheimers. Dement., 14 (7). S. 913 - 925. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1552-5279

Full text not available from this repository.

Abstract

Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P <.05) but not in A beta+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE E4 prevalence in AD was higher than that in previous studies, which did not require presence of A beta pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mattsson, NiklasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Groot, ColinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jansen, Willemijn J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Landau, Susan M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Villemagne, Victor L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Engelborghs, SebastiaanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mintun, Mark M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lleo, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Molinuevo, Jose LuisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jagust, William J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frisoni, Giovanni B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ivanoiu, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chetelat, GaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Oliveira, Catarina ResendeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodrigue, Karen M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDorcid.org/0000-0002-8096-3987UNSPECIFIED
Wallin, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klimkowicz-Mrowiec, AleksandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kandimalla, RameshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Popp, JuliusUNSPECIFIEDorcid.org/0000-0002-0068-0312UNSPECIFIED
Aalten, Pauline P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Aarsland, DagUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alcolea, DanielUNSPECIFIEDorcid.org/0000-0002-3819-3245UNSPECIFIED
Almdahl, Ina S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baldeiras, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Buchem, Mark A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cavedo, EnricaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chen, KeweiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cohen, Ann D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Foerster, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fortea, JuanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frederiksen, Kristian S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Freund-Levi, YvonneUNSPECIFIEDorcid.org/0000-0001-6863-6679UNSPECIFIED
Gill, Kiran DipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gkatzima, OlymbiaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grimmer, TimoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hampel, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herukka, Sanna-KaisaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Johannsen, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Laere, KoenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Leon, Mony J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Marcusson, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Meulenbroek, OlgaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mollergard, Hanne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, John C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mroczko, BarbaraUNSPECIFIEDorcid.org/0000-0002-4075-8479UNSPECIFIED
Nordlund, ArtoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Prabhakar, SudeshUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rami, LorenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodriguez-Rodriguez, EloyUNSPECIFIEDorcid.org/0000-0001-7742-677XUNSPECIFIED
Roe, Catherine M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruther, EckartUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Santana, IsabelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroder, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seo, Sang W.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soininen, HilkkaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spiru, LuizaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stomrud, ErikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Struyfs, HanneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teunissen, Charlotte E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verhey, Frans R. J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vos, Stephanie J. B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Doorn, Linda J. C. van WaalwijkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Waldemar, GunhildUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wallin, Asa K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDorcid.org/0000-0003-1492-5330UNSPECIFIED
Vandenberghe, RikUNSPECIFIEDorcid.org/0000-0001-6237-2502UNSPECIFIED
Brooks, David J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fladby, TormodUNSPECIFIEDorcid.org/0000-0002-9984-9797UNSPECIFIED
Rowe, Christopher C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drzezga, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Verbeek, Marcel M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sarazin, MarieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wolk, David A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fleisher, Adam S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klunk, William E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Na, Duk L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sanchez-Juan, PascualUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lee, Dong YoungUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nordberg, AgnetaUNSPECIFIEDorcid.org/0000-0001-7345-5151UNSPECIFIED
Tsolaki, MagdaUNSPECIFIEDorcid.org/0000-0002-2072-8010UNSPECIFIED
Camus, VincentUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rinne, Juha O.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fagan, Anne M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zetterberg, HenrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Blennow, KajUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rabinovici, Gil D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hansson, OskarUNSPECIFIEDorcid.org/0000-0001-8467-7286UNSPECIFIED
van Berckel, Bart N. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van der Flier, Wiesje M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scheltens, PhilipUNSPECIFIEDorcid.org/0000-0002-1046-6408UNSPECIFIED
Visser, Pieter JelleUNSPECIFIEDorcid.org/0000-0001-8008-9727UNSPECIFIED
Ossenkoppele, RikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-180203
DOI: 10.1016/j.jalz.2018.02.009
Journal or Publication Title: Alzheimers. Dement.
Volume: 14
Number: 7
Page Range: S. 913 - 925
Date: 2018
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1552-5279
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CEREBROSPINAL-FLUID BIOMARKERS; MILD COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE; APOE GENOTYPE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; LONGITUDINAL COHORT; GLUCOSE-METABOLISM; CSF BIOMARKERS; OLDER-ADULTSMultiple languages
Clinical NeurologyMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/18020

Downloads

Downloads per month over past year

Altmetric

Export

Actions (login required)

View Item View Item