Mattsson, Niklas, Groot, Colin, Jansen, Willemijn J., Landau, Susan M., Villemagne, Victor L., Engelborghs, Sebastiaan, Mintun, Mark M., Lleo, Alberto, Molinuevo, Jose Luis, Jagust, William J., Frisoni, Giovanni B., Ivanoiu, Adrian, Chetelat, Gael, de Oliveira, Catarina Resende, Rodrigue, Karen M., Kornhuber, Johannes ORCID: 0000-0002-8096-3987, Wallin, Anders, Klimkowicz-Mrowiec, Aleksandra, Kandimalla, Ramesh, Popp, Julius ORCID: 0000-0002-0068-0312, Aalten, Pauline P., Aarsland, Dag, Alcolea, Daniel ORCID: 0000-0002-3819-3245, Almdahl, Ina S., Baldeiras, Ines, van Buchem, Mark A., Cavedo, Enrica, Chen, Kewei, Cohen, Ann D., Foerster, Stefan, Fortea, Juan, Frederiksen, Kristian S., Freund-Levi, Yvonne ORCID: 0000-0001-6863-6679, Gill, Kiran Dip, Gkatzima, Olymbia, Grimmer, Timo, Hampel, Harald, Herukka, Sanna-Kaisa, Johannsen, Peter, van Laere, Koen, de Leon, Mony J., Maier, Wolfgang, Marcusson, Jan, Meulenbroek, Olga, Mollergard, Hanne M., Morris, John C., Mroczko, Barbara ORCID: 0000-0002-4075-8479, Nordlund, Arto, Prabhakar, Sudesh, Peters, Oliver, Rami, Lorena, Rodriguez-Rodriguez, Eloy ORCID: 0000-0001-7742-677X, Roe, Catherine M., Ruther, Eckart, Santana, Isabel, Schroder, Johannes, Seo, Sang W., Soininen, Hilkka, Spiru, Luiza, Stomrud, Erik, Struyfs, Hanne, Teunissen, Charlotte E., Verhey, Frans R. J., Vos, Stephanie J. B., van Doorn, Linda J. C. van Waalwijk, Waldemar, Gunhild, Wallin, Asa K., Wiltfang, Jens ORCID: 0000-0003-1492-5330, Vandenberghe, Rik ORCID: 0000-0001-6237-2502, Brooks, David J., Fladby, Tormod ORCID: 0000-0002-9984-9797, Rowe, Christopher C., Drzezga, Alexander, Verbeek, Marcel M., Sarazin, Marie, Wolk, David A., Fleisher, Adam S., Klunk, William E., Na, Duk L., Sanchez-Juan, Pascual, Lee, Dong Young, Nordberg, Agneta ORCID: 0000-0001-7345-5151, Tsolaki, Magda ORCID: 0000-0002-2072-8010, Camus, Vincent, Rinne, Juha O., Fagan, Anne M., Zetterberg, Henrik, Blennow, Kaj, Rabinovici, Gil D., Hansson, Oskar ORCID: 0000-0001-8467-7286, van Berckel, Bart N. M., van der Flier, Wiesje M., Scheltens, Philip ORCID: 0000-0002-1046-6408, Visser, Pieter Jelle ORCID: 0000-0001-8008-9727 and Ossenkoppele, Rik
(2018).
Prevalence of the apolipoprotein E epsilon 4 allele in amyloid beta positive subjects across the spectrum of Alzheimer's disease.
Alzheimers. Dement., 14 (7).
S. 913 - 925.
NEW YORK:
ELSEVIER SCIENCE INC.
ISSN 1552-5279
Full text not available from this repository.
Abstract
Introduction: Apolipoprotein E (APOE) epsilon 4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid beta(A beta) pathology. Methods: We included 3451 A beta+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE epsilon 4 prevalence in relation to age, sex, education, and geographical location. Results: The APOE epsilon 4 prevalence was 66% in AD-type dementia, 64% in mild cognitive impairment, and 51% in cognitively normal, and it decreased with advancing age in A beta+ cognitively normal and A beta+ mild cognitive impairment (P <.05) but not in A beta+ AD dementia (P =.66). The prevalence was highest in Northern Europe but did not vary by sex or education. Discussion: The APOE E4 prevalence in AD was higher than that in previous studies, which did not require presence of A beta pathology. Furthermore, our results highlight disease heterogeneity related to age and geographical location. (C) 2018 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
Item Type: |
Journal Article
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Creators: |
Creators | Email | ORCID | ORCID Put Code |
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Mattsson, Niklas | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Groot, Colin | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jansen, Willemijn J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Landau, Susan M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Villemagne, Victor L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Engelborghs, Sebastiaan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mintun, Mark M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lleo, Alberto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Molinuevo, Jose Luis | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Jagust, William J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Frisoni, Giovanni B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ivanoiu, Adrian | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chetelat, Gael | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de Oliveira, Catarina Resende | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rodrigue, Karen M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kornhuber, Johannes | UNSPECIFIED | orcid.org/0000-0002-8096-3987 | UNSPECIFIED | Wallin, Anders | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Klimkowicz-Mrowiec, Aleksandra | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Kandimalla, Ramesh | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Popp, Julius | UNSPECIFIED | orcid.org/0000-0002-0068-0312 | UNSPECIFIED | Aalten, Pauline P. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Aarsland, Dag | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Alcolea, Daniel | UNSPECIFIED | orcid.org/0000-0002-3819-3245 | UNSPECIFIED | Almdahl, Ina S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Baldeiras, Ines | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van Buchem, Mark A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cavedo, Enrica | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Chen, Kewei | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Cohen, Ann D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Foerster, Stefan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fortea, Juan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Frederiksen, Kristian S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Freund-Levi, Yvonne | UNSPECIFIED | orcid.org/0000-0001-6863-6679 | UNSPECIFIED | Gill, Kiran Dip | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Gkatzima, Olymbia | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Grimmer, Timo | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hampel, Harald | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Herukka, Sanna-Kaisa | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Johannsen, Peter | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van Laere, Koen | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | de Leon, Mony J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Maier, Wolfgang | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Marcusson, Jan | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Meulenbroek, Olga | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mollergard, Hanne M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Morris, John C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Mroczko, Barbara | UNSPECIFIED | orcid.org/0000-0002-4075-8479 | UNSPECIFIED | Nordlund, Arto | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Prabhakar, Sudesh | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Peters, Oliver | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rami, Lorena | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rodriguez-Rodriguez, Eloy | UNSPECIFIED | orcid.org/0000-0001-7742-677X | UNSPECIFIED | Roe, Catherine M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Ruther, Eckart | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Santana, Isabel | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Schroder, Johannes | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Seo, Sang W. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Soininen, Hilkka | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Spiru, Luiza | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Stomrud, Erik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Struyfs, Hanne | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Teunissen, Charlotte E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Verhey, Frans R. J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Vos, Stephanie J. B. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van Doorn, Linda J. C. van Waalwijk | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Waldemar, Gunhild | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wallin, Asa K. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wiltfang, Jens | UNSPECIFIED | orcid.org/0000-0003-1492-5330 | UNSPECIFIED | Vandenberghe, Rik | UNSPECIFIED | orcid.org/0000-0001-6237-2502 | UNSPECIFIED | Brooks, David J. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fladby, Tormod | UNSPECIFIED | orcid.org/0000-0002-9984-9797 | UNSPECIFIED | Rowe, Christopher C. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Drzezga, Alexander | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Verbeek, Marcel M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sarazin, Marie | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Wolk, David A. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fleisher, Adam S. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Klunk, William E. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Na, Duk L. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Sanchez-Juan, Pascual | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Lee, Dong Young | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Nordberg, Agneta | UNSPECIFIED | orcid.org/0000-0001-7345-5151 | UNSPECIFIED | Tsolaki, Magda | UNSPECIFIED | orcid.org/0000-0002-2072-8010 | UNSPECIFIED | Camus, Vincent | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rinne, Juha O. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Fagan, Anne M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Zetterberg, Henrik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Blennow, Kaj | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Rabinovici, Gil D. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Hansson, Oskar | UNSPECIFIED | orcid.org/0000-0001-8467-7286 | UNSPECIFIED | van Berckel, Bart N. M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | van der Flier, Wiesje M. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED | Scheltens, Philip | UNSPECIFIED | orcid.org/0000-0002-1046-6408 | UNSPECIFIED | Visser, Pieter Jelle | UNSPECIFIED | orcid.org/0000-0001-8008-9727 | UNSPECIFIED | Ossenkoppele, Rik | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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URN: |
urn:nbn:de:hbz:38-180203 |
DOI: |
10.1016/j.jalz.2018.02.009 |
Journal or Publication Title: |
Alzheimers. Dement. |
Volume: |
14 |
Number: |
7 |
Page Range: |
S. 913 - 925 |
Date: |
2018 |
Publisher: |
ELSEVIER SCIENCE INC |
Place of Publication: |
NEW YORK |
ISSN: |
1552-5279 |
Language: |
English |
Faculty: |
Unspecified |
Divisions: |
Unspecified |
Subjects: |
no entry |
Uncontrolled Keywords: |
Keywords | Language |
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CEREBROSPINAL-FLUID BIOMARKERS; MILD COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE; APOE GENOTYPE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; LONGITUDINAL COHORT; GLUCOSE-METABOLISM; CSF BIOMARKERS; OLDER-ADULTS | Multiple languages | Clinical Neurology | Multiple languages |
|
Refereed: |
Yes |
URI: |
http://kups.ub.uni-koeln.de/id/eprint/18020 |
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