Koehl, Ulrike, Arsenieva, Stanislava, Holzinger, Astrid and Abken, Hinrich (2018). CAR T Cells in Trials: Recent Achievements and Challenges that Remain in the Production of Modified T Cells for Clinical Applications. Hum. Gene Ther., 29 (5). S. 559 - 569. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1557-7422
Full text not available from this repository.Abstract
The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing interest for the treatment of malignant diseases. Early trials with anti-CD19 CAR T cells have achieved spectacular remissions in B-cell leukemia and lymphoma, so far refractory, very recently resulting in the Food and Drug Administration approval of CD19 CAR T cells for therapy. With further applications and increasing numbers of patients, the reproducible manufacture of high-quality clinical-grade CAR T cells is becoming an ever greater challenge. New processing techniques, quality-control mechanisms, and logistic developments are required to meet both medical needs and regulatory restrictions. This paper summarizes the state-of-the-art in manufacturing CAR T cells and the current challenges that need to be overcome to implement this type of cell therapy in the treatment of a variety of malignant diseases and in a greater number of patients.
Item Type: | Journal Article | ||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-189666 | ||||||||||||||||||||
DOI: | 10.1089/hum.2017.254 | ||||||||||||||||||||
Journal or Publication Title: | Hum. Gene Ther. | ||||||||||||||||||||
Volume: | 29 | ||||||||||||||||||||
Number: | 5 | ||||||||||||||||||||
Page Range: | S. 559 - 569 | ||||||||||||||||||||
Date: | 2018 | ||||||||||||||||||||
Publisher: | MARY ANN LIEBERT, INC | ||||||||||||||||||||
Place of Publication: | NEW ROCHELLE | ||||||||||||||||||||
ISSN: | 1557-7422 | ||||||||||||||||||||
Language: | English | ||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/18966 |
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