Universität zu Köln

Beati, Hamze, Peek, Irina, Hordowska, Paulina, Honemann-Capito, Mona, Glashauser, Jade, Renschler, Fabian A., Kakanj, Parisa, Ramrath, Andreas, Leptin, Maria ORCID: 0000-0001-7097-348X, Luschnig, Stefan, Wiesner, Silke ORCID: 0000-0003-0015-0167 and Wodarz, Andreas ORCID: 0000-0002-0007-6289 (2018). The adherens junction-associated LIM domain protein Smallish regulates epithelial morphogenesis. J. Cell Biol., 217 (3). S. 1079 - 1096. NEW YORK: ROCKEFELLER UNIV PRESS. ISSN 1540-8140

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Abstract

In epithelia, cells adhere to each other in a dynamic fashion, allowing the cells to change their shape and move along each other during morphogenesis. The regulation of adhesion occurs at the belt-shaped adherens junction, the zonula adherens (ZA). Formation of the ZA depends on components of the Par-atypical PKC (Par-aPKC) complex of polarity regulators. We have identified the Lin11, Isl-1, Mec-3 (LIM) protein Smallish (Smash), the orthologue of vertebrate LMO7, as a binding partner of Bazooka/Par-3 (Baz), a core component of the Par-aPKC complex. Smash also binds to Canoe/Afadin and the tyrosine kinase Src42A and localizes to the ZA in a planar polarized fashion. Animals lacking Smash show loss of planar cell polarity (PCP) in the embryonic epidermis and reduced cell bond tension, leading to severe defects during embryonic morphogenesis of epithelial tissues and organs. Overexpression of Smash causes apical constriction of epithelial cells. We propose that Smash is a key regulator of morphogenesis coordinating PCP and actomyosin contractility at the ZA.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Beati, Hamze UNSPECIFIED UNSPECIFIED UNSPECIFIED Peek, Irina UNSPECIFIED UNSPECIFIED UNSPECIFIED Hordowska, Paulina UNSPECIFIED UNSPECIFIED UNSPECIFIED Honemann-Capito, Mona UNSPECIFIED UNSPECIFIED UNSPECIFIED Glashauser, Jade UNSPECIFIED UNSPECIFIED UNSPECIFIED Renschler, Fabian A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kakanj, Parisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramrath, Andreas UNSPECIFIED UNSPECIFIED UNSPECIFIED Leptin, Maria UNSPECIFIED orcid.org/0000-0001-7097-348X UNSPECIFIED Luschnig, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiesner, Silke UNSPECIFIED orcid.org/0000-0003-0015-0167 UNSPECIFIED Wodarz, Andreas UNSPECIFIED orcid.org/0000-0002-0007-6289 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-194449
DOI:	10.1083/jcb.201610098
Journal or Publication Title:	J. Cell Biol.
Volume:	217
Number:	3
Page Range:	S. 1079 - 1096
Date:	2018
Publisher:	ROCKEFELLER UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1540-8140
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CADHERIN-MEDIATED ADHESION; APICAL CONSTRICTION; DROSOPHILA-MELANOGASTER; ACTOMYOSIN CONTRACTILITY; CONVERGENT EXTENSION; ACTIN CYTOSKELETON; PLANAR POLARITY; GENE-EXPRESSION; DORSAL CLOSURE; SHROOM Multiple languages Cell Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/19444