Mannil, Manoj, Hickethier, Tilman, von Spiczak, Jochen, Baer, Matthias, Henning, Andre, Hertel, Madeleine, Schmidt, Bernhard, Flohr, Thomas, Maintz, David and Alkadhi, Hatem (2018). Photon-Counting CT High-Resolution Imaging of Coronary Stents. Invest. Radiol., 53 (3). S. 143 - 150. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. ISSN 1536-0210

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Abstract

Purpose: The aim of this study was to investigate computed tomography (CT) imaging characteristics of coronary stents using a novel photon-counting detector (PCD) in comparison with a conventional energy-integrating detector (EID). Materials and Methods: In this in vitro study, 18 different coronary stents were expanded in plastic tubes of 3 mm diameter, were filled with contrast agent (diluted to an attenuation of 250 Hounsfield units [HU] at 120 kVp), and were sealed. Stents were placed in an oil-filled custom phantom calibrated to an attenuation of -100 HU at 120 kVp for resembling pericardial fat. The phantom was positioned in the gantry at 2 different angles at 0 degree and 90 degrees relative to the z axis, and was imaged in a research dual-source PCD-CT scanner. Detector subsystemA used a standard 64-row EID, while detector subsystem B used a PCD, allowing high-resolution scanning (detector pixel-size 0.250 x 0.250 mm in the isocenter). Images were obtained from both detector systems at identical tube voltage (100 kVp) and tube current-time product (100 mA), and were both reconstructed using a typical convolution kernel for stent imaging (B46f) and using the same reconstruction parameters. Two independent, blinded readers evaluated in-stent visibility and measured noise, intraluminal stent diameter, and in-stent attenuation for each detector subsystem. Differences in noise, intraluminal stent diameter, and in-stent attenuation where tested using a paired t test; differences in subjective in-stent visibility were evaluated using aWilcoxon signed-rank test. Results: Best results for in-stent visibility, noise, intraluminal stent diameter, and in-stent attenuation in EID and PCD were observed at 0-degree phantom position along the z axis, suggesting higher in-plane compared with through plane resolution. Subjective in-stent visibility was superior in coronary stent images obtained from PCD compared with EID (P < 0.001). Mean in-stent diameter was 28.8% and 8.4% greater in PCD (0.85 +/- 0.24 mm; 0.83 +/- 0.14 mm) as compared with EID acquisitions (0.66 +/- 0.21 mm; 0.76 +/- 0.13 mm) for both 0-degree and 90-degree phantom positions, respectively. Average noise was significantly lower (P < 0.001) for PCD (5 +/- 0.2 HU) compared with EID (8.3 +/- 0.2HU). The increase in in-stent attenuation (0 degree: Delta 245 +/- 163 HU vs Delta 156.5 +/- 126 HU; P = 0.006; 90 degrees: Delta 194 +/- 141 HU vs Delta 126 +/- 78 HU; P = 0.001) was significantly lower for PCD compared with EID acquisitions. Conclusions: At matched CT scan protocol settings and identical image reconstruction parameters, the PCD yields superior in-stent lumen delineation of coronary artery stents as compared with conventional EID arrays.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Mannil, ManojUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hickethier, TilmanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
von Spiczak, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baer, MatthiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Henning, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hertel, MadeleineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schmidt, BernhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Flohr, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maintz, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alkadhi, HatemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-195131
DOI: 10.1097/RLI.0000000000000420
Journal or Publication Title: Invest. Radiol.
Volume: 53
Number: 3
Page Range: S. 143 - 150
Date: 2018
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Place of Publication: PHILADELPHIA
ISSN: 1536-0210
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CONTRAST COMPUTED-TOMOGRAPHY; IN-VITRO EVALUATION; ARTERY STENTS; ANGIOGRAPHY; RECONSTRUCTIONS; DETECTORMultiple languages
Radiology, Nuclear Medicine & Medical ImagingMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/19513

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