Universität zu Köln

von Stebut, Esther and Tenzer, Stefan ORCID: 0000-0003-3034-0017 (2018). Cutaneous leishmaniasis: Distinct functions of dendritic cells and macrophages in the interaction of the host immune system with Leishmania major. Int. J. Med. Microbiol., 308 (1). S. 206 - 215. MUNICH: ELSEVIER GMBH. ISSN 1618-0607

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Abstract

Leishmaniasis is transmitted by sand flies leading to parasite inoculation into skin. In the mammalian host, the parasite primarily resides in skin macrophages (M Phi) and dendritic cells (DC). M Phi are silently invaded by the parasite eliciting a stress response, whereas DC become activated, release IL-12, and prime antigen-specific T cells. Here we review the basics of the immune response against this human pathogen and elucidate the role and function DC and M Phi for establishment of protective immunity against leishmaniasis. We focus on cell type specific differences in parasite uptake, phagocyte activation and processing of parasite antigens to facilitate an understanding how their respective function may be modulated e.g. under therapeutic considerations.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code von Stebut, Esther UNSPECIFIED UNSPECIFIED UNSPECIFIED Tenzer, Stefan UNSPECIFIED orcid.org/0000-0003-3034-0017 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-200561
DOI:	10.1016/j.ijmm.2017.11.002
Journal or Publication Title:	Int. J. Med. Microbiol.
Volume:	308
Number:	1
Page Range:	S. 206 - 215
Date:	2018
Publisher:	ELSEVIER GMBH
Place of Publication:	MUNICH
ISSN:	1618-0607
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CD8(+) T-CELLS; EPIDERMAL LANGERHANS CELLS; PARASITOPHOROUS VACUOLES; PERSISTENT PARASITES; IL-12 PRODUCTION; INFECTION; RELEASE; SUSCEPTIBILITY; BIOGENESIS; ACTIVATION Multiple languages Microbiology; Virology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20056