Universität zu Köln

Pfaar, Oliver, Classen, Dan Philipp, Astvatsatourov, Anatoli, Klimek, Ludger and Moesges, Ralph (2018). Reliability of a New Symptom Score in a Titrated Quantitative Conjunctival Provocation Test Supported by an Objective Photodocumentation. Int. Arch. Allergy Immunol., 176 (3-4). BASEL: KARGER. ISSN 1423-0097

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Abstract

Background: Allergen provocation tests are useful methods for proving the clinical relevance of an allergen-specific sensitization. Among these methods, the conjunctival provocation test (CPT) represents an easy-to-use tool. However, its readout parameters have not yet been internationally standardized or validated. Photodocumentation has been shown as a good option for objectifying a CPT reaction, supporting the local investigator assessment. Based on test-retest reliability of the score and an objective digital photoanalysis of the conjunctival redness, this study aimed to prove the reproducibility of a new CPT scoring system for use in clinical trials (ClinicalTrials. gov identifier: NCT02690740). Methods: A titrated quantitative CPT was conducted outside of the pollen season in a final cohort of 23 adult patients with birch or grass pollen-induced allergic rhinoconjunctivitis. Conjunctival symptoms were analyzed using a standardized symptom score. Conjunctival redness was also evaluated by an external observer and correlated with a digital photoanalysis using MATLAB software. Results: A test-retest correlation of 0.6 (p < 0.01) was found for the symptom score results. Likewise, a correlation of 0.65 (p < 0.01) was observed in the digital photoanalysis. The total symptom score showed a decrease in the mean value of 0.48 score points in the retest. Conclusions: This study reveals both a valuable test-retest correlation of the proposed score as well as a good correlation of eye redness with the (objective) photodocumentation. Based on our results, we can recommend the use of this scoring system as a valuable clinical protocol for future clinical trials. (C) 2018 S. Karger AG, Basel

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pfaar, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Classen, Dan Philipp UNSPECIFIED UNSPECIFIED UNSPECIFIED Astvatsatourov, Anatoli UNSPECIFIED UNSPECIFIED UNSPECIFIED Klimek, Ludger UNSPECIFIED UNSPECIFIED UNSPECIFIED Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202341
DOI:	10.1159/000487884
Journal or Publication Title:	Int. Arch. Allergy Immunol.
Volume:	176
Number:	3-4
Date:	2018
Publisher:	KARGER
Place of Publication:	BASEL
ISSN:	1423-0097
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ALLERGIC RHINITIS; DERMATOPHAGOIDES-PTERONYSSINUS; SKIN PRICK; IMMUNOTHERAPY; INFLAMMATION; CHALLENGE; PRECISION; EFFICACY; SAFETY; ADULTS Multiple languages Allergy; Immunology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20234