Universität zu Köln

Teipel, Stefan J., Metzger, Coraline D., Brosseron, Frederic, Buerger, Katharina, Brueggen, Katharina, Catak, Cihan, Diesing, Dominik, Dobisch, Laura, Fliessbach, Klaus, Franke, Christiana, Heneka, Michael T., Kilimann, Ingo, Kofler, Barbara, Menne, Felix, Peters, Oliver, Polcher, Alexandra, Priller, Josef ORCID: 0000-0001-7596-0979, Schneider, Anja ORCID: 0000-0001-9540-8700, Spottke, Annika, Spruth, Eike J., Thelen, Manuela, Thyrian, Rene J., Wagner, Michael ORCID: 0000-0003-2589-6440, Duezel, Emrah, Jessen, Frank and Dyrba, Martin ORCID: 0000-0002-3353-3167 (2018). Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease. J. Alzheimers Dis., 64 (3). S. 801 - 814. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: Alterations of intrinsic networks from resting state fMRI (rs-fMRI) have been suggested as functional biomarkers of Alzheimer's disease (AD). Objective: To determine the diagnostic accuracy of multicenter rs-fMRI for prodromal and preclinical stages of AD. Methods: We determined rs-fMRI functional connectivity based on Pearson's correlation coefficients and amplitude of low-frequency fluctuation in people with subjective cognitive decline, people with mild cognitive impairment, and people with AD dementia compared with healthy controls. We used data of 247 participants of the prospective DELCODE study, a longitudinal multicenter observational study, imposing a unified fMRI acquisition protocol across sites. We determined cross-validated discrimination accuracy based on penalized logistic regression to account for multicollinearity of predictors. Results: Resting state functional connectivity reached significant cross-validated group discrimination only for the comparison of AD dementia cases with healthy controls, but not for the other diagnostic groups. AD dementia cases showed alterations in a large range of intrinsic resting state networks, including the default mode and salience networks, but also executive and language networks. When groups were stratified according to their CSF amyloid status that was available in a subset of cases, diagnostic accuracy was increased for amyloid positive mild cognitive impairment cases compared with amyloid negative controls, but still inferior to the accuracy of hippocampus volume. Conclusion: Even when following a strictly harmonized data acquisition protocol and rigorous scan quality control, widely used connectivity measures of multicenter rs-fMRI do not reach levels of diagnostic accuracy sufficient for a useful biomarker in prodromal stages of AD.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Teipel, Stefan J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Metzger, Coraline D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Brosseron, Frederic UNSPECIFIED UNSPECIFIED UNSPECIFIED Buerger, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Brueggen, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED Catak, Cihan UNSPECIFIED UNSPECIFIED UNSPECIFIED Diesing, Dominik UNSPECIFIED UNSPECIFIED UNSPECIFIED Dobisch, Laura UNSPECIFIED UNSPECIFIED UNSPECIFIED Fliessbach, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Franke, Christiana UNSPECIFIED UNSPECIFIED UNSPECIFIED Heneka, Michael T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kilimann, Ingo UNSPECIFIED UNSPECIFIED UNSPECIFIED Kofler, Barbara UNSPECIFIED UNSPECIFIED UNSPECIFIED Menne, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Polcher, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Priller, Josef UNSPECIFIED orcid.org/0000-0001-7596-0979 UNSPECIFIED Schneider, Anja UNSPECIFIED orcid.org/0000-0001-9540-8700 UNSPECIFIED Spottke, Annika UNSPECIFIED UNSPECIFIED UNSPECIFIED Spruth, Eike J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thelen, Manuela UNSPECIFIED UNSPECIFIED UNSPECIFIED Thyrian, Rene J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Michael UNSPECIFIED orcid.org/0000-0003-2589-6440 UNSPECIFIED Duezel, Emrah UNSPECIFIED UNSPECIFIED UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Dyrba, Martin UNSPECIFIED orcid.org/0000-0002-3353-3167 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-202466
DOI:	10.3233/JAD-180106
Journal or Publication Title:	J. Alzheimers Dis.
Volume:	64
Number:	3
Page Range:	S. 801 - 814
Date:	2018
Publisher:	IOS PRESS
Place of Publication:	AMSTERDAM
ISSN:	1875-8908
Language:	English
Faculty:	Faculty of Management, Economy and Social Sciences
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; EIGENVECTOR CENTRALITY; DIAGNOSTIC GUIDELINES; HARMONIZED PROTOCOL; NATIONAL INSTITUTE; FMRI; PREDICTION; BIOMARKERS; RECOMMENDATIONS Multiple languages Neurosciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/20246