Teipel, Stefan J., Metzger, Coraline D., Brosseron, Frederic, Buerger, Katharina, Brueggen, Katharina, Catak, Cihan, Diesing, Dominik, Dobisch, Laura, Fliessbach, Klaus, Franke, Christiana, Heneka, Michael T., Kilimann, Ingo, Kofler, Barbara, Menne, Felix, Peters, Oliver, Polcher, Alexandra, Priller, Josef ORCID: 0000-0001-7596-0979, Schneider, Anja ORCID: 0000-0001-9540-8700, Spottke, Annika, Spruth, Eike J., Thelen, Manuela, Thyrian, Rene J., Wagner, Michael ORCID: 0000-0003-2589-6440, Duezel, Emrah, Jessen, Frank and Dyrba, Martin ORCID: 0000-0002-3353-3167 (2018). Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease. J. Alzheimers Dis., 64 (3). S. 801 - 814. AMSTERDAM: IOS PRESS. ISSN 1875-8908

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Abstract

Background: Alterations of intrinsic networks from resting state fMRI (rs-fMRI) have been suggested as functional biomarkers of Alzheimer's disease (AD). Objective: To determine the diagnostic accuracy of multicenter rs-fMRI for prodromal and preclinical stages of AD. Methods: We determined rs-fMRI functional connectivity based on Pearson's correlation coefficients and amplitude of low-frequency fluctuation in people with subjective cognitive decline, people with mild cognitive impairment, and people with AD dementia compared with healthy controls. We used data of 247 participants of the prospective DELCODE study, a longitudinal multicenter observational study, imposing a unified fMRI acquisition protocol across sites. We determined cross-validated discrimination accuracy based on penalized logistic regression to account for multicollinearity of predictors. Results: Resting state functional connectivity reached significant cross-validated group discrimination only for the comparison of AD dementia cases with healthy controls, but not for the other diagnostic groups. AD dementia cases showed alterations in a large range of intrinsic resting state networks, including the default mode and salience networks, but also executive and language networks. When groups were stratified according to their CSF amyloid status that was available in a subset of cases, diagnostic accuracy was increased for amyloid positive mild cognitive impairment cases compared with amyloid negative controls, but still inferior to the accuracy of hippocampus volume. Conclusion: Even when following a strictly harmonized data acquisition protocol and rigorous scan quality control, widely used connectivity measures of multicenter rs-fMRI do not reach levels of diagnostic accuracy sufficient for a useful biomarker in prodromal stages of AD.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Teipel, Stefan J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Metzger, Coraline D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brosseron, FredericUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buerger, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brueggen, KatharinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Catak, CihanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diesing, DominikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dobisch, LauraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fliessbach, KlausUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Franke, ChristianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heneka, Michael T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kilimann, IngoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kofler, BarbaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Menne, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Polcher, AlexandraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Priller, JosefUNSPECIFIEDorcid.org/0000-0001-7596-0979UNSPECIFIED
Schneider, AnjaUNSPECIFIEDorcid.org/0000-0001-9540-8700UNSPECIFIED
Spottke, AnnikaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Spruth, Eike J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thelen, ManuelaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thyrian, Rene J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, MichaelUNSPECIFIEDorcid.org/0000-0003-2589-6440UNSPECIFIED
Duezel, EmrahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dyrba, MartinUNSPECIFIEDorcid.org/0000-0002-3353-3167UNSPECIFIED
URN: urn:nbn:de:hbz:38-202466
DOI: 10.3233/JAD-180106
Journal or Publication Title: J. Alzheimers Dis.
Volume: 64
Number: 3
Page Range: S. 801 - 814
Date: 2018
Publisher: IOS PRESS
Place of Publication: AMSTERDAM
ISSN: 1875-8908
Language: English
Faculty: Faculty of Management, Economy and Social Sciences
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MILD COGNITIVE IMPAIRMENT; ASSOCIATION WORKGROUPS; EIGENVECTOR CENTRALITY; DIAGNOSTIC GUIDELINES; HARMONIZED PROTOCOL; NATIONAL INSTITUTE; FMRI; PREDICTION; BIOMARKERS; RECOMMENDATIONSMultiple languages
NeurosciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/20246

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