Universität zu Köln

Baessler, Bettina ORCID: 0000-0002-3244-3864, Treutlein, Melanie, Schaarschmidt, Frank, Stehning, Christian, Schnackenburg, Bernhard, Michels, Guido, Maintz, David and Bunck, Alexander C. (2017). A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. J. Cardiov. Magn. Reson., 19. LONDON: BMC. ISSN 1532-429X

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Abstract

Background: The aim of this study was to evaluate the diagnostic potential of a novel cardiovascular magnetic resonance (CMR) based multiparametric imaging approach in suspected myocarditis and to compare it to traditional Lake Louise criteria (LLC). Methods: CMR data from 67 patients with suspected acute myocarditis were retrospectively analyzed. Seventeen age-and gender-matched healthy subjects served as control. T2-mapping data were acquired using a Gradient-Spin-Echo T2-mapping sequence in short-axis orientation. T2-maps were segmented according to the 16-segments AHA-model and segmental T2 values and pixel-standard deviation (SD) were recorded. Afterwards, the parameters maxT2 (the highest segmental T2 value) and madSD (the mean absolute deviation (MAD) of the pixel-SDs) were calculated for each subject. Cine sequences in three long axes and a stack of short-axis views covering the left and right ventricle were analyzed using a dedicated feature tracking algorithm. Results: A multiparametric imaging model containing madSD and LV global circumferential strain (GCS(LV)) resulted in the highest diagnostic performance in receiver operating curve analyses (area under the curve [AUC] 0.84) when compared to any model containing a single imaging parameter or to LLC (AUC 0.79). Adding late gadolinium enhancement (LGE) to the model resulted in a further increased diagnostic performance (AUC 0.93) and yielded the highest diagnostic sensitivity of 97% and specificity of 77%. Conclusions: A multiparametric CMR imaging model including the novel T2-mapping derived parameter madSD, the feature tracking derived strain parameter GCSLV and LGE yields superior diagnostic sensitivity in suspected acute myocarditis when compared to any imaging parameter alone and to LLC.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Baessler, Bettina UNSPECIFIED orcid.org/0000-0002-3244-3864 UNSPECIFIED Treutlein, Melanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaarschmidt, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Stehning, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Schnackenburg, Bernhard UNSPECIFIED UNSPECIFIED UNSPECIFIED Michels, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED Maintz, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Bunck, Alexander C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-217498
DOI:	10.1186/s12968-017-0387-x
Journal or Publication Title:	J. Cardiov. Magn. Reson.
Volume:	19
Date:	2017
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1532-429X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CARDIAC MAGNETIC-RESONANCE; DIAGNOSTIC PERFORMANCE; CURRENT STATE Multiple languages Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical Imaging Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/21749