Universität zu Köln

Smith, Patrick, Willemsen, David, Popkes, Miriam, Metge, Franziska, Gandiwa, Edson ORCID: 0000-0003-0708-350X, Reichard, Martin ORCID: 0000-0002-9306-0074 and Valenzano, Dario Riccardo ORCID: 0000-0002-8761-8289 (2017). Regulation of life span by the gut microbiota in the short-lived African turquoise killifish. eLife, 6. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Gut bacteria occupy the interface between the organism and the external environment, contributing to homeostasis and disease. Yet, the causal role of the gut microbiota during host aging is largely unexplored. Here, using the African turquoise killifish (Nothobranchius furzeri), a naturally short-lived vertebrate, we show that the gut microbiota plays a key role in modulating vertebrate life span. Recolonizing the gut of middle-age individuals with bacteria from young donors resulted in life span extension and delayed behavioral decline. This intervention prevented the decrease in microbial diversity associated with host aging and maintained a young-like gut bacterial community, characterized by overrepresentation of the key genera Exiguobacterium, Planococcus, Propionigenium and Psychrobacter. Our findings demonstrate that the natural microbial gut community of young individuals can causally induce long-lasting beneficial systemic effects that lead to life span extension in a vertebrate model.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Smith, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Willemsen, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Popkes, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Metge, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Gandiwa, Edson UNSPECIFIED orcid.org/0000-0003-0708-350X UNSPECIFIED Reichard, Martin UNSPECIFIED orcid.org/0000-0002-9306-0074 UNSPECIFIED Valenzano, Dario Riccardo UNSPECIFIED orcid.org/0000-0002-8761-8289 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-221583
DOI:	10.7554/eLife.27014
Journal or Publication Title:	eLife
Volume:	6
Date:	2017
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ANNUAL FISHES; CAENORHABDITIS-ELEGANS; MODEL SYSTEM; NOTHOBRANCHIUS; TRANSPLANTATION; TEMPERATURE; LONGEVITY; INSIGHTS; OBESITY; HOMEOSTASIS Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22158