Universität zu Köln

Moesges, Ralph, Shah-Hosseini, Kija ORCID: 0000-0001-9616-6942, Hucke, Hans-Peter and Joisten, Marie-Josefine (2017). Dexpanthenol: An Overview of its Contribution to Symptom Relief in Acute Rhinitis Treated with Decongestant Nasal Sprays. Adv. Ther., 34 (8). S. 1850 - 1859. NEW YORK: SPRINGER. ISSN 1865-8652

Full text not available from this repository.

Abstract

Nasal blockage is the most bothersome symptom of acute rhinitis. Nasal decongestant sprays containing alpha-sympathomimetics, such as oxymetazoline and xylometazoline, have a rapid onset of action. However, this effect decreases with repeated application and, furthermore, the ciliary function of the nasal mucosa is practically paralyzed. Dexpanthenol promotes cell proliferation and protects the epithelium. Combining these two agents has demonstrated beneficial synergetic effects on the symptoms of acute rhinitis. In a post hoc analysis of a large-scale double-blind, active-controlled study including 152 patients, we could demonstrate that the benefit of added dexpanthenol appears as early as on the third day of the combined application of xylometazoline and dexpanthenol in terms of complete or near-to-complete freedom from symptoms. After 5 days, 47% of the patients were cured under the combined treatment compared with only 1% under xylometazoline monotherapy. These data show that the addition of dexpanthenol to an alpha-sympathomimetic nasal spray not only improves its tolerability but also further increases its effectiveness and leads to expedited cure.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Moesges, Ralph UNSPECIFIED UNSPECIFIED UNSPECIFIED Shah-Hosseini, Kija UNSPECIFIED orcid.org/0000-0001-9616-6942 UNSPECIFIED Hucke, Hans-Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Joisten, Marie-Josefine UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-222793
DOI:	10.1007/s12325-017-0581-0
Journal or Publication Title:	Adv. Ther.
Volume:	34
Number:	8
Page Range:	S. 1850 - 1859
Date:	2017
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1865-8652
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language COMMON COLD; ALLERGIC RHINITIS; DOUBLE-BLIND; XYLOMETAZOLINE; OXYMETAZOLINE; PLACEBO; ISCHEMIA; EFFICACY; INJURY; SAFETY Multiple languages Medicine, Research & Experimental; Pharmacology & Pharmacy Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22279