Universität zu Köln

Bicker, Frank, Vasic, Verica, Horta, Guilherme, Ortega, Felipe ORCID: 0000-0001-6398-9520, Nolte, Hendrik, Kavyanifar, Atria, Keller, Stefanie, Stankovic, Nevenka Dudvarski, Harter, Patrick N. ORCID: 0000-0001-5530-6910, Benedito, Rui ORCID: 0000-0003-2458-3055, Lutz, Beat, Baeuerle, Tobias, Hartwig, Jens, Baumgart, Jan, Krueger, Marcus ORCID: 0000-0003-2008-4582, Radyushkin, Konstantin, Alberi, Lavinia, Berninger, Benedikt ORCID: 0000-0003-2652-2782 and Schmidt, Mirko H. H. (2017). Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bicker, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Vasic, Verica UNSPECIFIED UNSPECIFIED UNSPECIFIED Horta, Guilherme UNSPECIFIED UNSPECIFIED UNSPECIFIED Ortega, Felipe UNSPECIFIED orcid.org/0000-0001-6398-9520 UNSPECIFIED Nolte, Hendrik UNSPECIFIED UNSPECIFIED UNSPECIFIED Kavyanifar, Atria UNSPECIFIED UNSPECIFIED UNSPECIFIED Keller, Stefanie UNSPECIFIED UNSPECIFIED UNSPECIFIED Stankovic, Nevenka Dudvarski UNSPECIFIED UNSPECIFIED UNSPECIFIED Harter, Patrick N. UNSPECIFIED orcid.org/0000-0001-5530-6910 UNSPECIFIED Benedito, Rui UNSPECIFIED orcid.org/0000-0003-2458-3055 UNSPECIFIED Lutz, Beat UNSPECIFIED UNSPECIFIED UNSPECIFIED Baeuerle, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartwig, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Baumgart, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Krueger, Marcus UNSPECIFIED orcid.org/0000-0003-2008-4582 UNSPECIFIED Radyushkin, Konstantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Alberi, Lavinia UNSPECIFIED UNSPECIFIED UNSPECIFIED Berninger, Benedikt UNSPECIFIED orcid.org/0000-0003-2652-2782 UNSPECIFIED Schmidt, Mirko H. H. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-227181
DOI:	10.1038/ncomms15922
Journal or Publication Title:	Nat. Commun.
Volume:	8
Date:	2017
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	2041-1723
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURAL STEM-CELLS; IN-VIVO; SUBEPENDYMAL ZONE; STIMULATES NEUROGENESIS; LINEAGE PROGRESSION; ENDOTHELIAL-CELLS; SELF-RENEWAL; BRAIN; NICHE; MOUSE Multiple languages Multidisciplinary Sciences Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/22718