Bicker, Frank, Vasic, Verica, Horta, Guilherme, Ortega, Felipe ORCID: 0000-0001-6398-9520, Nolte, Hendrik, Kavyanifar, Atria, Keller, Stefanie, Stankovic, Nevenka Dudvarski, Harter, Patrick N. ORCID: 0000-0001-5530-6910, Benedito, Rui ORCID: 0000-0003-2458-3055, Lutz, Beat, Baeuerle, Tobias, Hartwig, Jens, Baumgart, Jan, Krueger, Marcus, Radyushkin, Konstantin, Alberi, Lavinia, Berninger, Benedikt ORCID: 0000-0003-2652-2782 and Schmidt, Mirko H. H. (2017). Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat. Commun., 8. LONDON: NATURE PUBLISHING GROUP. ISSN 2041-1723

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Abstract

Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bicker, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vasic, VericaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Horta, GuilhermeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ortega, FelipeUNSPECIFIEDorcid.org/0000-0001-6398-9520UNSPECIFIED
Nolte, HendrikUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kavyanifar, AtriaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Keller, StefanieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stankovic, Nevenka DudvarskiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Harter, Patrick N.UNSPECIFIEDorcid.org/0000-0001-5530-6910UNSPECIFIED
Benedito, RuiUNSPECIFIEDorcid.org/0000-0003-2458-3055UNSPECIFIED
Lutz, BeatUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baeuerle, TobiasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hartwig, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Baumgart, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Krueger, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Radyushkin, KonstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alberi, LaviniaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Berninger, BenediktUNSPECIFIEDorcid.org/0000-0003-2652-2782UNSPECIFIED
Schmidt, Mirko H. H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-227181
DOI: 10.1038/ncomms15922
Journal or Publication Title: Nat. Commun.
Volume: 8
Date: 2017
Publisher: NATURE PUBLISHING GROUP
Place of Publication: LONDON
ISSN: 2041-1723
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NEURAL STEM-CELLS; IN-VIVO; SUBEPENDYMAL ZONE; STIMULATES NEUROGENESIS; LINEAGE PROGRESSION; ENDOTHELIAL-CELLS; SELF-RENEWAL; BRAIN; NICHE; MOUSEMultiple languages
Multidisciplinary SciencesMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/22718

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