Universität zu Köln

Messroghli, Daniel R., Pickardt, Thomas ORCID: 0000-0003-0019-6325, Fischer, Marcus, Opgen-Rhein, Bernd ORCID: 0000-0002-4535-4529, Papakostas, Konstantin, Bocker, Dorothee, Jakob, Andre, Khalil, Markus, Mueller, Goetz C., Sclunidt, Florian, Kaestner, Michael, ten Cate, Floris E. A. Udink, Wagner, Robert, Ruf, Bettina, Kiski, Daniela, Wiegand, Gesa, Degener, Franziska, Bauer, Ulrike M. M., Friede, Tim ORCID: 0000-0001-5347-7441 and Schubert, Stephan (2017). Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform. Am. Heart J., 187. S. 133 - 145. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-5330

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Abstract

Aims The aim of this registry is to provide data on age-related clinical features of suspected myocarditis and to create a study platform allowing for deriving diagnostic criteria and, at a later stage, testing therapeutic interventions in patients with myocarditis. Study design and results After an initial 6-month pilot phase, MYKKE was opened in June 2014 as a prospective multicenter registry for patients from pediatric heart centers, university hospitals, and community hospitals with pediatric cardiology wards in Germany. Inclusion criteria consisted of age < 18 years and hospitalization for suspected myocarditis as leading diagnosis at the discretion of the treating physician. By December 31, 2015, fifteen centers across Germany were actively participating and had enrolled 149 patients. Baseline data reveal 2 age peaks (< 2 years, > 12 years), show higher proportions of males, and document a high prevalence of severe disease courses in pediatric patients with suspected myocarditis. Severe clinical courses and early adverse events were more prevalent in younger patients and were related to severely impaired leftventricular ejection fraction at initial presentation. Summary MYKKE represents a multicenter registry and research platform for children and adolescents with suspected myocarditis that achieve steady recruitment and generate a wide range of real-world data on clinical course, diagnostic workup, and treatment of this group of patients. The baseline data reveal the presence of 2 age peaks and provide important insights into the severity of disease in children with suspected myocarditis. In the future, MYKKE might facilitate interventional substudies by providing an established collaborating network using common diagnostic approaches.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Messroghli, Daniel R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pickardt, Thomas UNSPECIFIED orcid.org/0000-0003-0019-6325 UNSPECIFIED Fischer, Marcus UNSPECIFIED UNSPECIFIED UNSPECIFIED Opgen-Rhein, Bernd UNSPECIFIED orcid.org/0000-0002-4535-4529 UNSPECIFIED Papakostas, Konstantin UNSPECIFIED UNSPECIFIED UNSPECIFIED Bocker, Dorothee UNSPECIFIED UNSPECIFIED UNSPECIFIED Jakob, Andre UNSPECIFIED UNSPECIFIED UNSPECIFIED Khalil, Markus UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Goetz C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sclunidt, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaestner, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED ten Cate, Floris E. A. Udink UNSPECIFIED UNSPECIFIED UNSPECIFIED Wagner, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Ruf, Bettina UNSPECIFIED UNSPECIFIED UNSPECIFIED Kiski, Daniela UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiegand, Gesa UNSPECIFIED UNSPECIFIED UNSPECIFIED Degener, Franziska UNSPECIFIED UNSPECIFIED UNSPECIFIED Bauer, Ulrike M. M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Friede, Tim UNSPECIFIED orcid.org/0000-0001-5347-7441 UNSPECIFIED Schubert, Stephan UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232111
DOI:	10.1016/j.ahj.2017.02.027
Journal or Publication Title:	Am. Heart J.
Volume:	187
Page Range:	S. 133 - 145
Date:	2017
Publisher:	MOSBY-ELSEVIER
Place of Publication:	NEW YORK
ISSN:	1097-5330
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EUROPEAN-SOCIETY; MANAGEMENT; CARDIOLOGY; STATEMENT Multiple languages Cardiac & Cardiovascular Systems Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23211