Messroghli, Daniel R., Pickardt, Thomas ORCID: 0000-0003-0019-6325, Fischer, Marcus, Opgen-Rhein, Bernd ORCID: 0000-0002-4535-4529, Papakostas, Konstantin, Bocker, Dorothee, Jakob, Andre, Khalil, Markus, Mueller, Goetz C., Sclunidt, Florian, Kaestner, Michael, ten Cate, Floris E. A. Udink, Wagner, Robert, Ruf, Bettina, Kiski, Daniela, Wiegand, Gesa, Degener, Franziska, Bauer, Ulrike M. M., Friede, Tim ORCID: 0000-0001-5347-7441 and Schubert, Stephan (2017). Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform. Am. Heart J., 187. S. 133 - 145. NEW YORK: MOSBY-ELSEVIER. ISSN 1097-5330

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Abstract

Aims The aim of this registry is to provide data on age-related clinical features of suspected myocarditis and to create a study platform allowing for deriving diagnostic criteria and, at a later stage, testing therapeutic interventions in patients with myocarditis. Study design and results After an initial 6-month pilot phase, MYKKE was opened in June 2014 as a prospective multicenter registry for patients from pediatric heart centers, university hospitals, and community hospitals with pediatric cardiology wards in Germany. Inclusion criteria consisted of age < 18 years and hospitalization for suspected myocarditis as leading diagnosis at the discretion of the treating physician. By December 31, 2015, fifteen centers across Germany were actively participating and had enrolled 149 patients. Baseline data reveal 2 age peaks (< 2 years, > 12 years), show higher proportions of males, and document a high prevalence of severe disease courses in pediatric patients with suspected myocarditis. Severe clinical courses and early adverse events were more prevalent in younger patients and were related to severely impaired leftventricular ejection fraction at initial presentation. Summary MYKKE represents a multicenter registry and research platform for children and adolescents with suspected myocarditis that achieve steady recruitment and generate a wide range of real-world data on clinical course, diagnostic workup, and treatment of this group of patients. The baseline data reveal the presence of 2 age peaks and provide important insights into the severity of disease in children with suspected myocarditis. In the future, MYKKE might facilitate interventional substudies by providing an established collaborating network using common diagnostic approaches.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Messroghli, Daniel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pickardt, ThomasUNSPECIFIEDorcid.org/0000-0003-0019-6325UNSPECIFIED
Fischer, MarcusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Opgen-Rhein, BerndUNSPECIFIEDorcid.org/0000-0002-4535-4529UNSPECIFIED
Papakostas, KonstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bocker, DorotheeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jakob, AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khalil, MarkusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mueller, Goetz C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sclunidt, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaestner, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
ten Cate, Floris E. A. UdinkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wagner, RobertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ruf, BettinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kiski, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiegand, GesaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Degener, FranziskaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bauer, Ulrike M. M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Friede, TimUNSPECIFIEDorcid.org/0000-0001-5347-7441UNSPECIFIED
Schubert, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-232111
DOI: 10.1016/j.ahj.2017.02.027
Journal or Publication Title: Am. Heart J.
Volume: 187
Page Range: S. 133 - 145
Date: 2017
Publisher: MOSBY-ELSEVIER
Place of Publication: NEW YORK
ISSN: 1097-5330
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
EUROPEAN-SOCIETY; MANAGEMENT; CARDIOLOGY; STATEMENTMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
Refereed: Yes
URI: http://kups.ub.uni-koeln.de/id/eprint/23211

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