Forner, Dirk Michael and Mallmann, Peter (2017). Neoadjuvant and definitive chemotherapy or chemoradiation for stage III and IV vulvar cancer: A pooled Reanalysis. Eur. J. Obstet. Gynecol. Reprod. Biol., 212. S. 115 - 119. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-7654
Full text not available from this repository.Abstract
Objectives and methods: A number of publications study the treatment of advanced vulvar cancer by neoadjuvant or definitive chemotherapy (CT) or chemoradiation (CRT); however, the reported survival rates vary widely. In a pooled reanalysis of the published data, we studied the factors influencing patients' survival. Results: We included 97 patients with stage III and IV vulvar cancer of publications in our study. In the pooled reanalysis we found that neoadjuvant therapy plus surgery lead to significantly better 5YSR (73%) than definitive CRT (43%) alone. No significant difference was found between CRT (5YSR: 69%) and CI' (77%, p = 0.11) in the neoadjuvant setting. In addition, patients showing a positive response to CT or CRT had a better 5YSR (67% vs. 20%, p=0.001). Conclusion: Neoadjuvant therapy plus surgery can improve survival of patients with advanced vulvar cancer. (C) 2017 Elsevier B.V. All rights reserved.
Item Type: | Journal Article | ||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-232279 | ||||||||||||
DOI: | 10.1016/j.ejogrb.2017.03.030 | ||||||||||||
Journal or Publication Title: | Eur. J. Obstet. Gynecol. Reprod. Biol. | ||||||||||||
Volume: | 212 | ||||||||||||
Page Range: | S. 115 - 119 | ||||||||||||
Date: | 2017 | ||||||||||||
Publisher: | ELSEVIER SCIENCE BV | ||||||||||||
Place of Publication: | AMSTERDAM | ||||||||||||
ISSN: | 1872-7654 | ||||||||||||
Language: | English | ||||||||||||
Faculty: | Unspecified | ||||||||||||
Divisions: | Unspecified | ||||||||||||
Subjects: | no entry | ||||||||||||
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Refereed: | Yes | ||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/23227 |
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