Universität zu Köln

Forner, Dirk Michael and Mallmann, Peter (2017). Neoadjuvant and definitive chemotherapy or chemoradiation for stage III and IV vulvar cancer: A pooled Reanalysis. Eur. J. Obstet. Gynecol. Reprod. Biol., 212. S. 115 - 119. AMSTERDAM: ELSEVIER SCIENCE BV. ISSN 1872-7654

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Abstract

Objectives and methods: A number of publications study the treatment of advanced vulvar cancer by neoadjuvant or definitive chemotherapy (CT) or chemoradiation (CRT); however, the reported survival rates vary widely. In a pooled reanalysis of the published data, we studied the factors influencing patients' survival. Results: We included 97 patients with stage III and IV vulvar cancer of publications in our study. In the pooled reanalysis we found that neoadjuvant therapy plus surgery lead to significantly better 5YSR (73%) than definitive CRT (43%) alone. No significant difference was found between CRT (5YSR: 69%) and CI' (77%, p = 0.11) in the neoadjuvant setting. In addition, patients showing a positive response to CT or CRT had a better 5YSR (67% vs. 20%, p=0.001). Conclusion: Neoadjuvant therapy plus surgery can improve survival of patients with advanced vulvar cancer. (C) 2017 Elsevier B.V. All rights reserved.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Forner, Dirk Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Mallmann, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-232279
DOI:	10.1016/j.ejogrb.2017.03.030
Journal or Publication Title:	Eur. J. Obstet. Gynecol. Reprod. Biol.
Volume:	212
Page Range:	S. 115 - 119
Date:	2017
Publisher:	ELSEVIER SCIENCE BV
Place of Publication:	AMSTERDAM
ISSN:	1872-7654
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SQUAMOUS-CELL CARCINOMA; GYNECOLOGIC-ONCOLOGY-GROUP; LOCALLY ADVANCED-CARCINOMA; PREOPERATIVE CHEMORADIATION; CERVICAL-CANCER; CONCURRENT RADIATION; RADICAL SURGERY; MITOMYCIN-C; PHASE-II; RECURRENT Multiple languages Obstetrics & Gynecology; Reproductive Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/23227