Seifert, Michael, Friedrich, Betty and Beyer, Andreas ORCID: 0000-0002-3891-2123
(2016).
Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis.
Genome Biol., 17.
LONDON:
BMC.
ISSN 1474-760X
Abstract
It has proven exceedingly difficult to ascertain rare copy number alterations (CNAs) that may have strong effects in individual tumors. We show that a regulatory network inferred from gene expression and gene copy number data of 768 human cancer cell lines can be used to quantify the impact of patient-specific CNAs on survival signature genes. A focused analysis of tumors from six tissues reveals that rare patient-specific gene CNAs often have stronger effects on signature genes than frequent gene CNAs. Further comparison to a related network-based approach shows that the integration of indirectly acting gene CNAs significantly improves the survival analysis.
Item Type: | Journal Article | ||||||||||||||||
Creators: |
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URN: | urn:nbn:de:hbz:38-258628 | ||||||||||||||||
DOI: | 10.1186/s13059-016-1058-1 | ||||||||||||||||
Journal or Publication Title: | Genome Biol. | ||||||||||||||||
Volume: | 17 | ||||||||||||||||
Date: | 2016 | ||||||||||||||||
Publisher: | BMC | ||||||||||||||||
Place of Publication: | LONDON | ||||||||||||||||
ISSN: | 1474-760X | ||||||||||||||||
Language: | English | ||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||
Subjects: | no entry | ||||||||||||||||
Uncontrolled Keywords: |
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Refereed: | Yes | ||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/25862 |
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