Universität zu Köln

Seifert, Michael, Friedrich, Betty and Beyer, Andreas ORCID: 0000-0002-3891-2123 (2016). Importance of rare gene copy number alterations for personalized tumor characterization and survival analysis. Genome Biol., 17. LONDON: BMC. ISSN 1474-760X

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Abstract

It has proven exceedingly difficult to ascertain rare copy number alterations (CNAs) that may have strong effects in individual tumors. We show that a regulatory network inferred from gene expression and gene copy number data of 768 human cancer cell lines can be used to quantify the impact of patient-specific CNAs on survival signature genes. A focused analysis of tumors from six tissues reveals that rare patient-specific gene CNAs often have stronger effects on signature genes than frequent gene CNAs. Further comparison to a related network-based approach shows that the integration of indirectly acting gene CNAs significantly improves the survival analysis.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Seifert, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Friedrich, Betty UNSPECIFIED UNSPECIFIED UNSPECIFIED Beyer, Andreas UNSPECIFIED orcid.org/0000-0002-3891-2123 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-258628
DOI:	10.1186/s13059-016-1058-1
Journal or Publication Title:	Genome Biol.
Volume:	17
Date:	2016
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1474-760X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SOMATIC MUTATIONS; HUMAN BREAST; CANCER; EXPRESSION; NETWORK; SIGNATURES; REVEALS; ACTIVATION; LANDSCAPE; MIGRATION Multiple languages Biotechnology & Applied Microbiology; Genetics & Heredity Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/25862