Kallendrusch, Sonja, Schopow, Nikolas, Stadler, Sonja C., Buening, Hildegard and Hacker, Ulrich T. (2016). Adeno-Associated Viral Vectors Transduce Mature Human Adipocytes in Three-Dimensional Slice Cultures. Hum. Gene Ther. Methods, 27 (5). S. 171 - 174. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1946-6544
Full text not available from this repository.Abstract
Adipose tissue plays a pivotal role, both in the regulation of energy homeostasis and as an endocrine organ. Consequently, adipose tissue dysfunction is closely related to insulin resistance, morbid obesity, and metabolic syndrome. To study molecular mechanisms and to develop novel therapeutic strategies, techniques are required to genetically modify mature adipocytes. Here, we report on adeno-associated viral (AAV) vectors as a versatile tool to transduce human mature adipocytes in organotypic three-dimensional tissue cultures.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-259560 | ||||||||||||||||||||||||
DOI: | 10.1089/hgtb.2016.137 | ||||||||||||||||||||||||
Journal or Publication Title: | Hum. Gene Ther. Methods | ||||||||||||||||||||||||
Volume: | 27 | ||||||||||||||||||||||||
Number: | 5 | ||||||||||||||||||||||||
Page Range: | S. 171 - 174 | ||||||||||||||||||||||||
Date: | 2016 | ||||||||||||||||||||||||
Publisher: | MARY ANN LIEBERT, INC | ||||||||||||||||||||||||
Place of Publication: | NEW ROCHELLE | ||||||||||||||||||||||||
ISSN: | 1946-6544 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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Refereed: | Yes | ||||||||||||||||||||||||
URI: | http://kups.ub.uni-koeln.de/id/eprint/25956 |
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